Search Results - "McCaughan, G."

Animal and translational models of SARS-CoV-2 infection and COVID-19 by Johansen, M. D., Irving, A., Montagutelli, X., Tate, M. D., Rudloff, I., Nold, M. F., Hansbro, N. G., Kim, R. Y., Donovan, C., Liu, G., Faiz, A., Short, K. R., Lyons, J. G., McCaughan, G. W., Gorrell, M. D., Cole, A., Moreno, C., Couteur, D., Hesselson, D., Triccas, J., Neely, G. G., Gamble, J. R., Simpson, S. J., Saunders, B. M., Oliver, B. G., Britton, W. J., Wark, P. A., Nold-Petry, C. A., Hansbro, P. M.

“…COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions…”
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2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejectio by Demetris, AJ, Bellamy, C, Hubscher, SG, O'Leary, J, Randhawa, PS, Feng, S, Neil, D, Colvin, RB, McCaughan, G, Fung, JJ

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Suicidal emperipolesis: a process leading to cell-in-cell structures, T cell clearance and immune homeostasis by Sierro, F, Tay, S S, Warren, A, Le Couteur, D G, McCaughan, G W, Bowen, D G, Bertolino, P

“…"Suicidal emperipolesis" is one of the most recently reported processes leading to cell-in-cell structures that promote cell death. This process was discovered…”
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Effect of viral suppression on hepatic venous pressure gradient in hepatitis C with cirrhosis and portal hypertension by Afdhal, N., Everson, G. T., Calleja, J. L., McCaughan, G. W., Bosch, J., Brainard, D. M., McHutchison, J. G., De‐Oertel, S., An, D., Charlton, M., Reddy, K. R., Asselah, T., Gane, E., Curry, M. P., Forns, X.

“…Summary Portal hypertension is a predictor of liver‐related clinical events and mortality in patients with hepatitis C and cirrhosis. The effect of…”
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Defining the temporal evolution of gut dysbiosis and inflammatory responses leading to hepatocellular carcinoma in Mdr2 -/- mouse model by Behary, J, Raposo, A E, Amorim, N M L, Zheng, H, Gong, L, McGovern, E, Chen, J, Liu, K, Beretov, J, Theocharous, C, Jackson, M T, Seet-Lee, J, McCaughan, G W, El-Omar, E M, Zekry, A

“…Emerging evidence implicates the gut microbiome in liver inflammation and hepatocellular carcinoma (HCC) development. We aimed to characterize the temporal…”
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Comparison of De Novo Cancer Incidence in Australian Liver, Heart and Lung Transplant Recipients by Na, R., Grulich, A. E., Meagher, N. S., McCaughan, G. W., Keogh, A. M., Vajdic, C. M.

“…Population‐based evidence on the relative risk of de novo cancer in liver and cardiothoracic transplant recipients is limited. A cohort study was conducted in…”
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De novo Cancer‐Related Death in Australian Liver and Cardiothoracic Transplant Recipients by Na, R., Grulich, A. E., Meagher, N. S., McCaughan, G. W., Keogh, A. M., Vajdic, C. M.

“…Evidence is sparse on the relative mortality risk posed by de novo cancers in liver and cardiothoracic transplant recipients. A retrospective cohort study was…”
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Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture by Apte, M V, Haber, P S, Applegate, T L, Norton, I D, McCaughan, G W, Korsten, M A, Pirola, R C, Wilson, J S

“…Background—The pathogenesis of pancreatic fibrosis is unknown. In the liver, stellate cells (vitamin A storing cells) play a significant role in the…”
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Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis by Apte, M V, Haber, P S, Darby, S J, Rodgers, S C, McCaughan, G W, Korsten, M A, Pirola, R C, Wilson, J S

“…BACKGROUND The pathogenesis of pancreatic fibrosis is unknown. In the liver, stellate cells play a major role in fibrogenesis by synthesising increased amounts…”
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Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection by Tu, T., Mason, W. S., Clouston, A. D., Shackel, N. A., McCaughan, G. W., Yeh, M. M., Schiff, E. R., Ruszkiewicz, A. R., Chen, J. W., Harley, H. A. J., Stroeher, U. H., Jilbert, A. R.

“…Summary Hepatocyte clone size was measured in liver samples of 21 patients in various stages of chronic hepatitis B virus (HBV) infection and from 21 to…”
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Fibrosis progression in chronic hepatitis C virus infection by McCaughan, G W, George, J

“…Chronic hepatitis C virus infection is typically characterised by slowly progressive hepatic fibrosis. However, it is recognised that some patients do not…”
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Intrahepatic immunity: a tale of two sites? by Bowen, David G., McCaughan, Geoffrey W., Bertolino, Patrick

“…The intrahepatic immune environment is associated with the induction of tolerance, yet maintains the capacity to sustain effective responses against pathogens…”
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Virus Genotype-Dependent Transcriptional Alterations in Lipid Metabolism and Inflammation Pathways in the Hepatitis C Virus-infected Liver by d’Avigdor, W. M. H., Budzinska, M. A., Lee, M., Lam, R., Kench, J., Stapelberg, M., McLennan, S. V., Farrell, G., George, J., McCaughan, G. W., Tu, T., Shackel, N. A.

“…Despite advances in antiviral therapy, molecular drivers of Hepatitis C Virus (HCV)-related liver disease remain poorly characterised. Chronic infection with…”
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CD26: A Multifunctional Integral Membrane and Secreted Protein of Activated Lymphocytes by Gorrell, M. D., Gysbers, V., McCaughan, G. W.

“…CD26 has proved interesting in the fields of immunology, endocrinology, cancer biology and nutrition owing to its ubiquitous and unusual enzyme activity. This…”
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Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection by McGuinness, P H, Painter, D, Davies, S, McCaughan, G W

“…BACKGROUND Upregulation of Th1 associated intrahepatic cytokines in chronic hepatitis C virus (HCV) infection should lead to a significant non-specific…”
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Organ donation in Australia by McCaughan, G

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Sofosbuvir and daclatasvir therapy in patients with hepatitis C‐related advanced decompensated liver disease (MELD ≥ 15) by McCaughan, G. W., Thwaites, P. A., Roberts, S. K., Strasser, S. I., Mitchell, J., Morales, B., Mason, S., Gow, P., Wigg, A., Tallis, C., Jeffrey, G., George, J., Thompson, A. J., Parker, F. C., Angus, P. W.

“…Summary Background Antiviral therapy for hepatitis C has the potential to improve liver function in patients with decompensated cirrhosis. Aims To examine the…”
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Have we significantly underestimated the capacity in the Australian health system to treat chronic hepatitis C infection in an interferon‐free era? by Kaan, I. A., Jones, T., McCaughan, G. W.

“…Background New antiviral therapies for hepatitis C infection may lead to an increase in capacity to treat because of their simplicity and safety. Aims To…”
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Characteristics and Treatment Outcomes among HIV-Infected Individuals in the Australian Trial in Acute Hepatitis C by Matthews, G. V., Hellard, M., Haber, P., Yeung, B., Marks, P., Baker, D., McCaughan, G., Sasadeusz, J., White, P., Rawlinson, W., Lloyd, A., Kaldor, J., Dore, G. J.

“…Background. The Australian Trial in Acute Hepatitis C (ATAHC) is a National Institutes of Health-funded prospective cohort study of the natural history and…”
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Whole genome sequencing analysis of familial primary sclerosing cholangitis by Budzinska, M, Cheng, R, Tu, T, Strasser, S, Mccaughan, G, Shackel, N

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