Search Results - "McCarver, D G"

Cytochrome P4502D6 ( ) Gene Locus Heterogeneity: Characterization of Gene Duplication Events by Gaedigk, A, Ndjountché, L, Divakaran, K, DiAnne Bradford, L, Zineh, I, Oberlander, T F, Brousseau, D C, McCarver, D G, Johnson, J A, Alander, S W, Wayne Riggs, K, Steven Leeder, J

“…Duplications and multiplications of active CYP2D6 genes can cause ultrarapid drug metabolism and lead to therapeutic failure. Multiple functional and…”
Get full text

Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: A case study with toluene by Nong, A., McCarver, D.G., Hines, R.N., Krishnan, K.

“…The objective of the present study was to evaluate the magnitude of interindividual variability in the internal dose of toluene in children of various age…”
Get full text

A genetic polymorphism in the regulatory sequences of human CYP2E1 association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake by MCCARVER, D. G, BYUN, R, HINES, R. N, HICHME, M, WEGENEK, W

“…To pursue the hypothesis that differences in the regulatory region of CYP2E1 are partially responsible for the intersubject variation in in vivo CYP2E1…”
Get full text

Alcohol dehydrogenase-23 allele protects against alcohol-related birth defects among African Americans by McCarver, D G, Thomasson, H R, Martier, S S, Sokol, R J, Li, T

“…Considerable variation in offspring outcome is observed after intrauterine alcohol exposure. The underlying mechanism may include genetic diversity in the…”
Get more information

Ethnic Differences in Human Flavin-Containing Monooxygenase 2 (FMO2) Polymorphisms: Detection of Expressed Protein in African-Americans by Whetstine, J.R, Yueh, M.-F, Hopp, K.A, McCarver, D.G, Williams, D.E, Park, C.-S, Kang, J.H, Cha, Y.-N, Dolphin, C.T, Shephard, E.A, Phillips, I.R, Hines, R.N

“…The flavin-containing monooxygenases (FMOs) are a family of xenobiotic-metabolizing enzymes that are expressed in a species- and tissue-specific manner. FMO2…”
Get full text

Development of dapsone toxicity in patients with inflammatory dermatoses: Activity of acetylation and hydroxylation of dapsone as risk factors by Bluhm, Ranata E., Adedoyin, Adedayo, McCarver, D. G., Branch, Robert A.

“…Background Alternative independent routes of dapsone metabolism include N‐hydroxylation to the hydroxylamine, a potentially toxic metabolite, by cytochrome…”
Get full text

Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny by Giebel, Nicholas L, Shadley, Jeffrey D, McCarver, D Gail, Dorko, Kenneth, Gramignoli, Roberto, Strom, Stephen C, Yan, Ke, Simpson, Pippa M, Hines, Ronald N

“…Variability in drug-metabolizing enzyme developmental trajectories contributes to interindividual differences in susceptibility to chemical toxicity and…”
Get full text

Developmental expression of human hepatic CYP2C9 and CYP2C19 by Koukouritaki, Sevasti B, Manro, Jason R, Marsh, Sandra A, Stevens, Jeffrey C, Rettie, Allan E, McCarver, D Gail, Hines, Ronald N

“…The CYP2C subfamily is responsible for metabolizing many important drugs and accounts for about 20% of the cytochrome p450 in adult liver. To determine…”
Get more information

Proximity of residence to trichloroethylene-emitting sites and increased risk of offspring congenital heart defects among older women by Yauck, Jennifer S., Malloy, Marsha E., Blair, Kathleen, Simpson, Pippa M., McCarver, D. Gail

“…BACKGROUND Previous studies suggest that trichloroethylene (TCE) is a selective cardiac teratogen. We tested the hypothesis that the odds of maternal residence…”
Get full text

ADH2 and CYP2E1 Genetic Polymorphisms: Risk Factors for Alcohol-Related Birth Defects by MCCARVER, D. Gail

“…Considerable variation in offspring outcome occurs following intrauterine ethanol exposure. The mechanism underlying this varying susceptibility may involve…”
Get full text

"Inactive" Ingredients in Pharmaceutical Products: Update (Subject Review) by Committee on Drugs

“…Because of an increasing number of reports of adverse reactions associated with pharmaceutical excipients, in 1985 the Committee on Drugs issued a position…”
Get full text

Ethnic differences in allelic frequency of two flavin-containing monooxygenase 3 (FMO3) polymorphisms: linkage and effects on in vivo and in vitro FMO activities by PARK, Chang-Shin, KANG, Ju-Hee, CHUNG, Woon-Gye, YI, Hyun-Gyu, PIE, Jae-Eun, PARK, Dong-Kyun, HINES, R. N, MCCARVER, D. G, CHA, Young-Nam

Get full text

Knowledge and Misconceptions Among Inner-City African-American Mothers Regarding Alcohol and Drug Use by Donnelly, Francis M., Mowery, Joy L, McCarver, D. Gail

“…Alcohol and drug knowledge of inner-city mothers was evaluated following an educational mailing, and the relationship between knowledge and alcohol and illicit…”
Get full text

Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies by McCarver-May, D.Gail, Kang, Jun, Aouthmany, Moustafa, Elton, Rhonda, Mowery, Joy L., Slovis, Thomas L., Kauffman, Ralph

“…In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious ( p<0.05) but…”
Get full text

Trichloroethylene Decreases Heat Shock Protein 90 Interactions with Endothelial Nitric Oxide Synthase: Implications for Endothelial Cell Proliferation by Ou, Jingsong, Ou, Zhijun, McCarver, D. Gail, Hines, Ronald N., Oldham, Keith T., Ackerman, Allan W., Pritchard, Kirkwood A.

“…Trichloroetheylene (TRI) is an environmental pollutant that has been linked to congenital heart defects (CHD). Endothelial nitric oxide synthase (eNOS)…”
Get full text

Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny by Hines, Ronald N, Simpson, Pippa M, McCarver, D Gail

“…Human hepatic carboxylesterase 1 and 2 (CES1 and CES2) are important for the disposition of ester- and amide-bond-containing pharmaceuticals and environmental…”
Get full text

Excess birth prevalence of Hypoplastic Left Heart syndrome in eastern Wisconsin for birth cohorts 1997-1999 by Cronk, Christine E., Pelech, Andrew N., Malloy, Marsha E., McCarver, D. Gail

“…BACKGROUND Hypoplastic Left Heart syndrome (HLHS) is a group of cardiac malformations involving underdevelopment of the left heart with an inability to…”
Get full text

Prevention of Medication Errors in the Pediatric Inpatient Setting by Berlin, Cheston M, McCarver, D Gail, Notterman, Daniel A, Ward, Robert M

“…Medication errors that occur on a pediatric medical/surgical inpatient care unit are usually avoidable. Several steps are recommended to reduce these errors,…”
Get full text

Genetic Polymorphisms in Human Drug Metabolic Enzymes by Miller, Mark Steven, McCarver, Deborah Gail, Bell, Douglas A., Eaton, David L., Goldstein, Joyce A.

“…Results obtained from both epidemiologic studies and experimental animal model systems have shown a wide range of phenotypic variation in the ability of…”
Get full text

Maternal assessment of infant development: associations with alcohol and drug use in pregnancy by Seagull, F N, Mowery, J L, Simpson, P M, Robinson, T R, Martier, S S, Sokol, R J, McCarver-May, D G

“…Surveillance by parental concern has been advocated to assess whether formal child developmental testing is needed. To determine whether alcohol intake or…”
Get more information