Search Results - "McCarty, Reid M."

Spectroscopic, Steady-State Kinetic, and Mechanistic Characterization of the Radical SAM Enzyme QueE, Which Catalyzes a Complex Cyclization Reaction in the Biosynthesis of 7‑Deazapurines by McCarty, Reid M, Krebs, Carsten, Bandarian, Vahe

“…7-Carboxy-7-deazaguanine (CDG) synthase (QueE) catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to…”
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GenK-Catalyzed C‑6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-Dependent Radical SAM Enzyme by Kim, Hak Joong, McCarty, Reid M, Ogasawara, Yasushi, Liu, Yung-nan, Mansoorabadi, Steven O, LeVieux, Jake, Liu, Hung-wen

“…The existence of cobalamin (Cbl)-dependent enzymes that are members of the radical S-adenosyl-l-methionine (SAM) superfamily was previously predicted on the…”
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The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars by Lin, Chia-I, McCarty, Reid M, Liu, Hung-wen

“…Carbohydrates serve many structural and functional roles in biology. While the majority of monosaccharides are characterized by the chemical composition…”
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Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification by Miles, Zachary D, McCarty, Reid M, Molnar, Gabriella, Bandarian, Vahe

“…Transfer RNA is one of the most richly modified biological molecules. Biosynthetic pathways that introduce these modifications are underexplored, largely…”
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The Deazapurine Biosynthetic Pathway Revealed: In Vitro Enzymatic Synthesis of PreQ0 from Guanosine 5′-Triphosphate in Four Steps by McCarty, Reid M, Somogyi, Árpád, Lin, Guangxin, Jacobsen, Neil E, Bandarian, Vahe

“…Deazapurine-containing secondary metabolites comprise a broad range of structurally diverse nucleoside analogues found throughout biology, including various…”
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Biochemical and Structural Studies of 6-Carboxy-5,6,7,8-tetrahydropterin Synthase Reveal the Molecular Basis of Catalytic Promiscuity within the Tunnel-fold Superfamily by Miles, Zachary D., Roberts, Sue A., McCarty, Reid M., Bandarian, Vahe

“…6-Pyruvoyltetrahydropterin synthase (PTPS) homologs in both mammals and bacteria catalyze distinct reactions using the same 7,8-dihydroneopterin triphosphate…”
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Reaction Catalyzed by GenK, a Cobalamin-Dependent Radical S‑Adenosyl‑l‑methionine Methyltransferase in the Biosynthetic Pathway of Gentamicin, Proceeds with Retention of Configuration by Kim, Hak Joong, Liu, Yung-nan, McCarty, Reid M, Liu, Hung-wen

“…Many cobalamin (Cbl)-dependent radical S-adenosyl-l-methionine (SAM) methyltransferases have been identified through sequence alignment and/or genetic…”
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The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems by Lin, Chia‐I., McCarty, Reid M., Liu, Hung‐wen

“…Chemical reactions that are named in honor of their true, or at least perceived, discoverers are known as “name reactions”. This Review is a collection of…”
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Biosynthesis of pyrrolopyrimidines by McCarty, Reid M., Bandarian, Vahe

“…[Display omitted] ► GTP is a precursor to all known 7-deazapurines. ► 7-Deazapurines are widely distributed in all kingdoms of life. ► Biosynthetic pathways…”
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Comparison of a PreQ1 Riboswitch Aptamer in Metabolite-bound and Free States with Implications for Gene Regulation by Jenkins, Jermaine L., Krucinska, Jolanta, McCarty, Reid M., Bandarian, Vahe, Wedekind, Joseph E.

“…Riboswitches are RNA regulatory elements that govern gene expression by recognition of small molecule ligands via a high affinity aptamer domain. Molecular…”
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Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism by Dowling, Daniel P, Bruender, Nathan A, Young, Anthony P, McCarty, Reid M, Bandarian, Vahe, Drennan, Catherine L

“…Crystal structures of QueE, a radical SAM enzyme that converts the purine base of GTP into a deazapurine found in natural products and tRNA, explain how the…”
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7‑Carboxy-7-deazaguanine Synthase: A Radical S‑Adenosyl‑l‑methionine Enzyme with Polar Tendencies by Bruender, Nathan A, Grell, Tsehai A. J, Dowling, Daniel P, McCarty, Reid M, Drennan, Catherine L, Bandarian, Vahe

“…Radical S-adenosyl-l-methionine (SAM) enzymes are widely distributed and catalyze diverse reactions. SAM binds to the unique iron atom of a site-differentiated…”
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The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps by McCarty, Reid M, Somogyi, Arpád, Lin, Guangxin, Jacobsen, Neil E, Bandarian, Vahe

“…Deazapurine-containing secondary metabolites comprise a broad range of structurally diverse nucleoside analogues found throughout biology, including various…”
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The Alpha Subunit of Nitrile Hydratase Is Sufficient for Catalytic Activity and Post-Translational Modification by Nelp, Micah T, Astashkin, Andrei V, Breci, Linda A, McCarty, Reid M, Bandarian, Vahe

“…Nitrile hydratases (NHases) possess a mononuclear iron or cobalt cofactor whose coordination environment includes rare post-translationally oxidized cysteine…”
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Escherichia coli QueD Is a 6-Carboxy-5,6,7,8-tetrahydropterin Synthase by McCarty, Reid M, Somogyi, Árpád, Bandarian, Vahe

“…To elucidate the early steps required during biosynthesis of a broad class of 7-deazapurine-containing natural products, we have studied the reaction catalyzed…”
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Die Enzymologie organischer Umwandlungen: Namensreaktionen in biologischen Systemen by Lin, Chia-I, McCarty, Reid M, Liu, Hung-wen

“…Chemische Reaktionen, die zu Ehren ihrer wahren oder zumindest wahrgenommenen Entdecker benannt sind, werden als “Namensreaktionen” bezeichnet. Dieser Aufsatz…”
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Deciphering Deazapurine Biosynthesis: Pathway for Pyrrolopyrimidine Nucleosides Toyocamycin and Sangivamycin by McCarty, Reid M., Bandarian, Vahe

“…Pyrrolopyrimidine nucleosides analogs, collectively referred to as deazapurines, are an important class of structurally diverse compounds found in a wide…”
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Die Enzymologie organischer Umwandlungen: Namensreaktionen in biologischen Systemen by Lin, Chia‐I., McCarty, Reid M., Liu, Hung‐wen

“…Chemische Reaktionen, die zu Ehren ihrer wahren oder zumindest wahrgenommenen Entdecker benannt sind, werden als “Namensreaktionen” bezeichnet. Dieser Aufsatz…”
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E. coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase by McCarty, Reid M., Somogyi, Árpád, Bandarian, Vahe

“…To elucidate the early steps required during biosynthesis of a broad class of 7-deazapurine containing natural products, we have studied the reaction catalyzed…”
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The Deazapurine Biosynthetic Pathway Revealed: In Vitro Enzymatic Synthesis of PreQ 0 from Guanosine 5′-Triphosphate in Four Steps by McCarty, Reid M., Somogyi, Árpád, Lin, Guangxin, Jacobsen, Neil E., Bandarian, Vahe

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