Search Results - "McCarty, Nael A."

Tweaking the catalytic efficiency of the CFTR ion channel by McCarty, Nael A

“…CFTR, unique among ABC transporters, evolved to function as an ion channel in part by optimizing the stability of the open state…”
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The "new normal": Adapting doctoral trainee career preparation for broad career paths in science by St Clair, Rebekah, Hutto, Tamara, MacBeth, Cora, Newstetter, Wendy, McCarty, Nael A, Melkers, Julia

“…Doctoral recipients in the biomedical sciences and STEM fields are showing increased interest in career opportunities beyond academic positions. While recent…”
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Effects of hyperglycemia on airway epithelial barrier function in WT and CF 16HBE cells by Vazquez Cegla, Analia J., Jones, Kymry T., Cui, Guiying, Cottrill, Kirsten A., Koval, Michael, McCarty, Nael A.

“…Cystic fibrosis related diabetes (CFRD), the main co-morbidity in cystic fibrosis (CF), is associated with higher rates of lung function decline. We…”
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Murine and human CFTR exhibit different sensitivities to CFTR potentiators by Cui, Guiying, McCarty, Nael A

“…Development of therapeutic molecules with clinical efficacy as modulators of defective CFTR includes efforts to identify potentiators that can overcome or…”
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Modeling the conformational changes underlying channel opening in CFTR by Rahman, Kazi S, Cui, Guiying, Harvey, Stephen C, McCarty, Nael A

“…Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator protein (CFTR) cause cystic fibrosis (CF), the most common…”
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Comparing ATPase activity of ATP-binding cassette subfamily C member 4, lamprey CFTR, and human CFTR using an antimony-phosphomolybdate assay by Cui, Guiying, Strickland, Kerry M, Vazquez Cegla, Analia J, McCarty, Nael A

“…ATP-binding cassette (ABC) transporters use the hydrolysis of ATP to power the active transport of molecules, but paradoxically the cystic fibrosis…”
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Junctional abnormalities in human airway epithelial cells expressing F508del CFTR by Molina, Samuel A, Stauffer, Brandon, Moriarty, Hannah K, Kim, Agnes H, McCarty, Nael A, Koval, Michael

“…Cystic fibrosis (CF) has a profound impact on airway physiology. Accumulating evidence suggests that intercellular junctions are impaired in CF. We examined…”
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Positioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulator by Infield, Daniel T, Cui, Guiying, Kuang, Christopher, McCarty, Nael A

“…The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is a chloride ion channel, the dysfunction of which directly leads to the life-shortening…”
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Development of a programmable automated cell culture system to study the lung pathophysiology of Cystic Fibrosis-related diabetes by Vazquez Cegla, Analia J., Hedden, Cameron, Imhoff, Barry R., Cui, Guiying, McCarty, Nael A.

“…The study of many diseases is limited by the in vitro systems available. Cystic Fibrosis-Related Diabetes (CFRD), the main co-morbidity of Cystic Fibrosis…”
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Flagellum-deficient Pseudomonas aeruginosa is more virulent than non-motile but flagellated mutants in a cystic fibrosis mouse model by Moustafa, Dina A, Fantone, Kayla M, Tucker, Samantha L, McCarty, Nael A, Stecenko, Arlene A, Goldberg, Joanna B, Rada, Balázs

“…Loss of the flagellum marks the pathoadaptation of to the cystic fibrosis (CF) airway environment during lung disease. Losing the flagellum is advantageous to…”
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Alteration of Membrane Cholesterol Content Plays a Key Role in Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Channel Activity by Cui, Guiying, Cottrill, Kirsten A., Strickland, Kerry M., Mashburn, Sarah A., Koval, Michael, McCarty, Nael A.

“…Altered cholesterol homeostasis in cystic fibrosis patients has been reported, although controversy remains. As a major membrane lipid component, cholesterol…”
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Correction: The "new normal": Adapting doctoral trainee career preparation for broad career paths in science by St Clair, Rebekah, Hutto, Tamara, MacBeth, Cora, Newstetter, Wendy, McCarty, Nael A, Melkers, Julia

“…[This corrects the article DOI: 10.1371/journal.pone.0177035.]…”
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Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR by Cui, Guiying, Rahman, Kazi S, Infield, Daniel T, Kuang, Christopher, Prince, Chengyu Z, McCarty, Nael A

“…The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) bears six extracellular loops (ECL1-6); ECL1 is the site of several mutations associated…”
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Inflammation and ER Stress Downregulate BDH2 Expression and Dysregulate Intracellular Iron in Macrophages by Zughaier, Susu M., McCarty, Nael A., Stauffer, Brandon B.

“…Macrophages play a very important role in host defense and in iron homeostasis by engulfing senescent red blood cells and recycling iron. Hepcidin is the…”
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Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR‐mediated apical conductance by Cottrill, Kirsten A., Peterson, Raven J., Lewallen, Colby F., Koval, Michael, Bridges, Robert J., McCarty, Nael A.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel whose dysfunction causes cystic fibrosis (CF). The loss of CFTR function in…”
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A transistor model for the cystic fibrosis transmembrane conductance regulator by Hunt, William D., McCarty, Nael A., Marin, Eduardo Martinez, Westafer, Ryan S., Yamin, Phillip R., Cui, Guiying, Eckford, Andrew W., Denison, Douglas R.

“…In this paper we present a transistor circuit model for cystic fibrosis transmembrane conductance regulator (CFTR) that seeks to map the functional form of…”
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Breathe-Your immune system is counting on it by McCarty, Nael A

“…Always, but especially in these times of COVID pandemic, we know the dangers of breathing into our lungs a deadly pathogen. Fortunately, healthy lungs are…”
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Permissive and nonpermissive channel closings in CFTR revealed by a factor graph inference algorithm by Moffett, Alexander S., Cui, Guiying, Thomas, Peter J., Hunt, William D., McCarty, Nael A., Westafer, Ryan S., Eckford, Andrew W.

“…The closing of the gated ion channel in the cystic fibrosis transmembrane conductance regulator can be categorized as nonpermissive to reopening, which…”
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Mechanistic analysis and significance of sphingomyelinase‐mediated decreases in transepithelial CFTR currents in nHBEs by Cottrill, Kirsten A., Giacalone, Vincent D., Margaroli, Camilla, Bridges, Robert J., Koval, Michael, Tirouvanziam, Rabindra, McCarty, Nael A.

“…Loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) causes cystic fibrosis (CF). In the lungs, this manifests as immune cell…”
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Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition by Peek, Mary E., Bhatnagar, Abhinav, McCarty, Nael A., Zughaier, Susu M.

“…Pseudomonas aeruginosa is the most common pathogen that persists in the cystic fibrosis lungs. Bacteria such as P. aeruginosa secrete siderophores…”
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