Search Results - "McCarty, N. A."

Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) by Stauffer, B. B., Cui, G., Cottrill, K. A., Infield, D. T., McCarty, N. A.

“…Sphingomyelinase C (SMase) inhibits CFTR chloride channel activity in multiple cell systems, an effect that could exacerbate disease in CF and COPD patients…”
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Calcium signaling in cell volume regulation by McCarty, N A, O'Neil, R G

“…It is evident from the present analysis that although a role for Ca2+ in controlling hypertonic cell volume regulation and RVI mechanisms has not been shown,…”
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Direct comparison of NPPB and DPC as probes of CFTR expressed in Xenopus oocytes by Zhang, Z R, Zeltwanger, S, McCarty, N A

“…Blockers of CFTR with well-characterized kinetics and mechanism of action will be useful as probes of pore structure. We have studied the mechanism of block of…”
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High-sweat Na+ in cystic fibrosis and healthy individuals does not diminish thirst during exercise in the heat by Brown, M B, McCarty, N A, Millard-Stafford, M

“…Sweat Na(+) concentration ([Na(+)]) varies greatly among individuals and is particularly high in cystic fibrosis (CF). The purpose of this study was to…”
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Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates by MCCARTY, N. A, MCDONOUGH, S, COHEN, B. N, RIORDAN, J. R, DAVIDSON, N, LESTER, H. A

“…The gene defective in cystic fibrosis encodes a Cl- channel, the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is blocked by…”
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Steady-state interactions of glibenclamide with CFTR: evidence for multiple sites in the pore by Zhang, Z R, Zeltwanger, S, McCarty, N A

“…The objective of the present study was to clarify the mechanism by which the sulfonylurea drug, glibenclamide, inhibits single CFTR channels in excised patches…”
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Time-dependent interactions of glibenclamide with CFTR: kinetically complex block of macroscopic currents by Zhang, Z-R, Cui, G, Zeltwanger, S, McCarty, N A

“…Blockade of the CFTR chloride channel by glibenclamide was studied in Xenopus oocytes using two-electrode voltage-clamp recordings, macropatch recordings, and…”
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Inhibition of ClC-2 chloride channels by a peptide component or components of scorpion venom by Thompson, C H, Fields, D M, Olivetti, P R, Fuller, M D, Zhang, Z R, Kubanek, J, McCarty, N A

“…ClC chloride channels play essential roles in membrane excitability and maintenance of osmotic balance. Despite the recent crystallization of two bacterial…”
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Dihydropyridine-sensitive cell volume regulation in proximal tubule: the calcium window by McCarty, N A, O'Neil, R G

“…The mechanism underlying the activation of hypotonic cell volume regulation was studied in rabbit proximal straight tubule (PST). When isolated non-perfused…”
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Permeation through the CFTR chloride channel by McCarty, N A

“…The cystic fibrosis transmembrane conductance regulator (CFTR) protein forms a Cl(-) channel found in the plasma membranes of many epithelial cells, including…”
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Relationship between airway ion transport and a mild pulmonary disease mutation in CFTR by Walker, L C, Venglarik, C J, Aubin, G, Weatherly, M R, McCarty, N A, Lesnick, B, Ruiz, F, Clancy, J P, Sorscher, E J

“…Patients with cystic fibrosis (CF) display defects in airway ion transport, but the influence of airway transport phenotype on improved prognosis is not known…”
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Identification of a region of strong discrimination in the pore of CFTR by McCarty, N A, Zhang, Z R

“…The variety of methods used to identify the structural determinants of anion selectivity in the cystic fibrosis transmembrane conductance regulator Cl(-)…”
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CFTR: covalent and noncovalent modification suggests a role for fixed charges in anion conduction by Smith, S S, Liu, X, Zhang, Z R, Sun, F, Kriewall, T E, McCarty, N A, Dawson, D C

“…The goal of the experiments described here was to explore the possible role of fixed charges in determining the conduction properties of CFTR. We focused on…”
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Novel pore-lining residues in CFTR that govern permeation and open-channel block by McDonough, S, Davidson, N, Lester, H A, McCarty, N A

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is both a member of the ATP-binding cassette superfamily and a Cl(-)-selective ion channel. We…”
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Conservation biology of a rare plant species. Eriocaulon kornickianum (Eriocaulaceae) by Watson, L.E, Uno, G.E, McCarty, N.A, Kornkven, A.B

“…Historical and current ecological and genetic factors were examined in western populations of Eriocaulon kornickianum to determine the cause and consequence of…”
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Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes by Uezono, Y, Bradley, J, Min, C, McCarty, N A, Quick, M, Riordan, J R, Chavkin, C, Zinn, K, Lester, H A, Davidson, N

“…The cystic fibrosis transmembrane conductance regulator (CFTR), a Cl- channel activated by phosphorylation, was expressed in Xenopus oocytes along with various…”
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Interaction Between Permeation and Gating in a Putative Pore Domain Mutant in the Cystic Fibrosis Transmembrane Conductance Regulator by Zhang, Zhi-Ren, McDonough, Stefan I., McCarty, Nael A.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel with distinctive kinetics. At the whole-cell level, CFTR currents in…”
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Effects of Serotonin on Intracellular pH and Contraction in Vascular Smooth Muscle by Kahn, Andrew M, Bishara, Maher, Cragoe, Edward J, Allen, Julius C, Seidel, Charles L, Navran, Stephen S, OʼNeil, Roger G, McCarty, Nael A, Shelat, Harnath

“…Serotonin (5-HT) and other contractile agonists stimulate Na-H exchange in vascular smooth muscle. Since intracellular alkalinization, per se, stimulates…”
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State-dependent Chemical Reactivity of an Engineered Cysteine Reveals Conformational Changes in the Outer Vestibule of the Cystic Fibrosis Transmembrane Conductance Regulator by Zhang, Zhi-Ren, Song, Binlin, McCarty, Nael A.

“…Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels are gated by binding and hydrolysis of ATP at the nucleotide-binding domains…”
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The Block of CFTR by Scorpion Venom is State-Dependent by Fuller, Matthew D., Zhang, Zhi-Ren, Cui, Guiying, McCarty, Nael A.

“…Cystic fibrosis transmembrane conductance regulator (CFTR) adenosine triphosphate-dependent chloride channels are expressed in epithelial cells and are…”
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