Search Results - "McCarty, Luke"

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells by Dillon, Michael, Yin, Yiyuan, Zhou, Jianhui, McCarty, Luke, Ellerman, Diego, Slaga, Dionysos, Junttila, Teemu T, Han, Guanghui, Sandoval, Wendy, Ovacik, Meric A, Lin, Kedan, Hu, Zhilan, Shen, Amy, Corn, Jacob E, Spiess, Christoph, Carter, Paul J

“…Bispecific IgG production in single host cells has been a much sought-after goal to support the clinical development of these complex molecules. Current routes…”
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Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing by Li, Ji, Stagg, Nicola J., Johnston, Jennifer, Harris, Michael J., Menzies, Sam A., DiCara, Danielle, Clark, Vanessa, Hristopoulos, Maria, Cook, Ryan, Slaga, Dionysos, Nakamura, Rin, McCarty, Luke, Sukumaran, Siddharth, Luis, Elizabeth, Ye, Zhengmao, Wu, Thomas D., Sumiyoshi, Teiko, Danilenko, Dimitry, Lee, Genee Y., Totpal, Klara, Ellerman, Diego, Hötzel, Isidro, James, John R., Junttila, Teemu T.

“…The anti-FcRH5/CD3 T cell-dependent bispecific antibody (TDB) targets the B cell lineage marker FcRH5 expressed in multiple myeloma (MM) tumor cells. We…”
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Facile quantitation of free thiols in a recombinant monoclonal antibody by reversed-phase high performance liquid chromatography with hydrophobicity-tailored thiol derivatization by Welch, Leslie, Dong, Xiao, Hewitt, Daniel, Irwin, Michelle, McCarty, Luke, Tsai, Christina, Baginski, Tomasz

“…Free thiol content, and its consistency, is one of the product quality attributes of interest during technical development of manufactured recombinant…”
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Characterization of Chain Pairing Variants of Bispecific IgG Expressed in a Single Host Cell by High-Resolution Native and Denaturing Mass Spectrometry by Schachner, Luis, Han, Guanghui, Dillon, Michael, Zhou, Jianhui, McCarty, Luke, Ellerman, Diego, Yin, Yiyuan, Spiess, Christoph, Lill, Jennie R, Carter, Paul J, Sandoval, Wendy

“…Bispecific antibodies, including bispecific IgG, show some promise in clinical trials as a means to extend the therapeutic potential of antibodies. Bispecific…”
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Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry by Yin, Yiyuan, Han, Guanghui, Zhou, Jianhui, Dillon, Michael, McCarty, Luke, Gavino, Lou, Ellerman, Diego, Spiess, Christoph, Sandoval, Wendy, Carter, Paul J

“…Bispecific IgG are heterotetramers comprising 2 pairs of heavy and light chains. Co-expression of the 4 component chains in a single host cell typically yields…”
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Anti-FcRH5/CD3 T Cell Dependent Bispecific Antibody (TDB) for the Treatment of Multiple Myeloma by Li, Ji, Stagg, Nicola, Johnston, Jennifer, Harris, Michael, Menzies, Sam, DiCara, Danielle, Clark, Vanessa, Cook, Ryan, Slaga, Dionysos, Nakamura, Rin, Luke, McCarty, Sukumaran, Siddharth, Luis, Elizabeth, Ye, Zhengmao, Sumiyoshi, Teiko, Danilenko, Dimitry, Lee, Genee, Totpal, Klara, Ellerman, Diego, Hötzel, Isidro, James, John, Junttila, Teemu T

“…Bispecific antibodies that retarget cytotoxic T cell activity to kill cancer cells are currently under clinical evaluation. However, the molecular mechanism…”
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Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry by Yin, Yiyuan, Han, Guanghui, Zhou, Jianhui, Dillon, Michael, McCarty, Luke, Gavino, Lou, Ellerman, Diego, Spiess, Christoph, Sandoval, Wendy, Carter, Paul J.

“…Bispecific IgG are heterotetramers comprising 2 pairs of heavy and light chains. Co-expression of the 4 component chains in a single host cell typically yields…”
Get full text

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells by Dillon, Michael, Yin, Yiyuan, Zhou, Jianhui, McCarty, Luke, Ellerman, Diego, Slaga, Dionysos, Junttila, Teemu T., Han, Guanghui, Sandoval, Wendy, Ovacik, Meric A., Lin, Kedan, Hu, Zhilan, Shen, Amy, Corn, Jacob E., Spiess, Christoph, Carter, Paul J.

“…Bispecific IgG production in single host cells has been a much sought-after goal to support the clinical development of these complex molecules. Current routes…”
Get full text