Search Results - "McCarty, David A"

Directed Engineering of a High-expression Chimeric Transgene as a Strategy for Gene Therapy of Hemophilia A by Doering, Christopher B, Denning, Gabriela, Dooriss, Kerry, Gangadharan, Bagirath, Johnston, Jennifer M, Kerstann, Keith W, McCarty, David A, Spencer, H Trent

“…Human coagulation factor VIII (fVIII) is inefficiently biosynthesized in vitro and has proven difficult to express at therapeutic levels using available…”
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Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia A by Dooriss, Kerry L, Denning, Gabriela, Gangadharan, Bagirath, Javazon, Elisabeth H, McCarty, David A, Spencer, H Trent, Doering, Christopher B

“…Successful gene therapy of hemophilia A depends on the sustained expression of therapeutic levels of factor VIII (fVIII). Because of mRNA instability,…”
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High-Expression Porcine FVIII Driven by Erythroid-Specific Promoters for Lentiviral Vector-Mediated Gene Therapy by Sutherland, Nadia, Dooriss, Kerry L, McCarty, David A, Doering, Christopher B, Spencer, H. Trent

“…Hemophilia A is an X-linked gene disorder that results in a deficiency of circulating coagulation factor VIII (fVIII) and may be ameliorated by only modest…”
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