Search Results - "McCartney, Amber J."

Phosphatidylinositol 3,5-bisphosphate: Low abundance, high significance by McCartney, Amber J., Zhang, Yanling, Weisman, Lois S.

“…Recent studies of the low abundant signaling lipid, phosphatidylinositol 3,5‐bisphosphate (PI(3,5)P2), reveal an intriguingly diverse list of downstream…”
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Local Presynaptic Activity Gates Homeostatic Changes in Presynaptic Function Driven by Dendritic BDNF Synthesis by Jakawich, Sonya K., Nasser, Hassan B., Strong, Michael J., McCartney, Amber J., Perez, Amanda S., Rakesh, Neal, Carruthers, Cynthia J.L., Sutton, Michael A.

“…Homeostatic synaptic plasticity is important for maintaining stability of neuronal function, but heterogeneous expression mechanisms suggest that distinct…”
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Activity-dependent PI(3,5)P₂ synthesis controls AMPA receptor trafficking during synaptic depression by McCartney, Amber J, Zolov, Sergey N, Kauffman, Emily J, Zhang, Yanling, Strunk, Bethany S, Weisman, Lois S, Sutton, Michael A

“…Significance Defects in biosynthesis of the signaling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P ₂] are associated with profound neurodegeneration…”
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Retrograde changes in presynaptic function driven by dendritic mTORC1 by Henry, Fredrick E, McCartney, Amber J, Neely, Ryan, Perez, Amanda S, Carruthers, Cynthia J L, Stuenkel, Edward L, Inoki, Ken, Sutton, Michael A

“…Mutations that alter signaling through the mammalian target of rapamycin complex 1 (mTORC1), a well established regulator of neuronal protein synthesis, have…”
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Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons by Cao, Mian, Wu, Yumei, Ashrafi, Ghazaleh, McCartney, Amber J., Wheeler, Heather, Bushong, Eric A., Boassa, Daniela, Ellisman, Mark H., Ryan, Timothy A., De Camilli, Pietro

“…Synaptojanin 1 (SJ1) is a major presynaptic phosphatase that couples synaptic vesicle endocytosis to the dephosphorylation of PI(4,5)P2, a reaction needed for…”
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Meta‐analysis of NIH Alzheimer’s Disease‐Related Dementias (ADRD) programs responsive to the National Plan to Address Alzheimer’s Disease (AD) by McCartney, Amber J, Shukla, Arvind, Yin, Xiling, Dodson, Sara, Bryant, Erin, Corriveau, Roderick A

“…Background AD/ADRD diseases currently impact more than 6 million people in the US. Rare forms of AD/ADRD are caused directly and unambiguously by genetic…”
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NINDS funding opportunities for Alzheimer’s Disease‐Related Dementia therapy development by Roof, Rebecca, Mcgavern, Linda, Boshoff, Chris, Lavaute, Timothy, Cywin, Charles, Thomas, Shruthi, McCartney, Amber J, Corriveau, Roderick A

“…Background Goal 1 of the National Plan to Address Alzheimer’s Disease (AD) is to prevent and effectively treat AD and AD‐related dementias (ADRD) by 2025…”
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Developing Topics by Roof, Rebecca, Mcgavern, Linda, Boshoff, Chris, Lavaute, Timothy, Cywin, Charles, Thomas, Shruthi, McCartney, Amber J, Corriveau, Roderick A

“…Goal 1 of the National Plan to Address Alzheimer's Disease (AD) is to prevent and effectively treat AD and AD-related dementias (ADRD) by 2025. Toward this…”
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Activity-dependent PI(3,5)P 2 synthesis controls AMPA receptor trafficking during synaptic depression by McCartney, Amber J., Zolov, Sergey N., Kauffman, Emily J., Zhang, Yanling, Strunk, Bethany S., Weisman, Lois S., Sutton, Michael A.

“…Significance Defects in biosynthesis of the signaling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P 2 ] are associated with profound neurodegeneration…”
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Activity-dependent PI(3,5)P₂ synthesis controls AMPA receptor trafficking during synaptic depression by McCartney, Amber J., Zolov, Sergey N., Kauffman, Emily J., Zhang, Yanling, Strunk, Bethany S., Weisman, Lois S., Sutton, Michael A.

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Activity-dependent PI(3,5)P^sub 2^ synthesis controls AMPA receptor trafficking during synaptic depression by McCartney, Amber J, Zolov, Sergey N, Kauffman, Emily J, Zhang, Yanling, Strunk, Bethany S, Weisman, Lois S, Sutton, Michael A

“…Dynamic regulation of phosphoinositide lipids (PIPs) is crucial for diverse cellular functions, and, in neurons, PIPs regulate membrane trafficking events that…”
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Activity-dependent PI(3,5)P sub( 2) synthesis controls AMPA receptor trafficking during synaptic depression by McCartney, Amber J, Zolov, Sergey N, Kauffman, Emily J, Zhang, Yanling, Strunk, Bethany S, Weisman, Lois S, Sutton, Michael A

“…Dynamic regulation of phosphoinositide lipids (PIPs) is crucial for diverse cellular functions, and, in neurons, PIPs regulate membrane trafficking events that…”
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Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P 2 and PI(5)P: VAC14 regulates synaptic function by Zhang, Yanling, McCartney, Amber J, Zolov, Sergey N, Ferguson, Cole J, Meisler, Miriam H, Sutton, Michael A, Weisman, Lois S

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Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P sub(2) and PI(5)P by Zhang, Yanling, McCartney, Amber J, Zolov, Sergey N, Ferguson, Cole J, Meisler, Miriam H, Sutton, Michael A, Weisman, Lois S

“…Normal steady-state levels of the signalling lipids PI(3,5)P sub(2) and PI(5)P require the lipid kinase FAB1/PIKfyve and its regulators, VAC14 and FIG4…”
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Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P2 and PI(5)P by Zhang, Yanling, McCartney, Amber J, Zolov, Sergey N, Ferguson, Cole J, Meisler, Miriam H, Sutton, Michael A, Weisman, Lois S

“…Normal steady‐state levels of the signalling lipids PI(3,5)P 2 and PI(5)P require the lipid kinase FAB1/PIKfyve and its regulators, VAC14 and FIG4. Mutations…”
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