Search Results - "McCarthy, Jeanette"

Genomic medicine: a decade of successes, challenges, and opportunities by McCarthy, Jeanette J, McLeod, Howard L, Ginsburg, Geoffrey S

“…Genomic medicine--an aspirational term 10 years ago--is gaining momentum across the entire clinical continuum from risk assessment in healthy individuals to…”
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Replicated Association Between an IL28B Gene Variant and a Sustained Response to Pegylated Interferon and Ribavirin by McCarthy, Jeanette J, Li, Josephine H, Thompson, Alexander, Suchindran, Sunil, Lao, Xiang Qian, Patel, Keyur, Tillmann, Hans L, Muir, Andrew J, McHutchison, John G

“…Background & Aims Patients with chronic hepatitis C virus (HCV) infections are treated with pegylated interferon and ribavirin (PEG-IFN/RBV), which is…”
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Artificial intelligence enables comprehensive genome interpretation and nomination of candidate diagnoses for rare genetic diseases by De La Vega, Francisco M, Chowdhury, Shimul, Moore, Barry, Frise, Erwin, McCarthy, Jeanette, Hernandez, Edgar Javier, Wong, Terence, James, Kiely, Guidugli, Lucia, Agrawal, Pankaj B, Genetti, Casie A, Brownstein, Catherine A, Beggs, Alan H, Löscher, Britt-Sabina, Franke, Andre, Boone, Braden, Levy, Shawn E, Õunap, Katrin, Pajusalu, Sander, Huentelman, Matt, Ramsey, Keri, Naymik, Marcus, Narayanan, Vinodh, Veeraraghavan, Narayanan, Billings, Paul, Reese, Martin G, Yandell, Mark, Kingsmore, Stephen F

“…Clinical interpretation of genetic variants in the context of the patient's phenotype is becoming the largest component of cost and time expenditure for…”
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Interferon‐lambda genotype and low serum low‐density lipoprotein cholesterol levels in patients with chronic hepatitis C infection by Li, Josephine H., Qian Lao, Xiang, Tillmann, Hans L., Rowell, Jennifer, Patel, Keyur, Thompson, Alexander, Suchindran, Sunil, Muir, Andrew J., Guyton, John R., Gardner, Stephen D., McHutchison, John G., McCarthy, Jeanette J.

“…Recently, genetic polymorphisms occurring in the interferon (IFN)‐lambda gene region were associated with response to IFN‐based treatment of hepatitis C…”
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The use of single-nucleotide polymorphism maps in pharmacogenomics by McCarthy, Jeanette J, Hilfiker, Rolf

“…Single-nucleotide polymorphisms (SNPs), common variations among the DNA of individuals, are being uncovered and assembled into large SNP databases that promise…”
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Characterization of the poly-T variant in the TOMM40 gene in diverse populations by Linnertz, Colton, Saunders, Ann M, Lutz, Michael W, Crenshaw, Donna M, Grossman, Iris, Burns, Daniel K, Whitfield, Keith E, Hauser, Michael A, McCarthy, Jeanette J, Ulmer, Megan, Allingham, Rand, Welsh-Bohmer, Kathleen A, Roses, Allen D, Chiba-Falek, Ornit

“…We previously discovered that a polymorphic, deoxythymidine-homopolymer (poly-T, rs10524523) in intron 6 of the TOMM40 gene is associated with age-of-onset of…”
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Genome-Wide Association Study of Lp-PLA2 Activity and Mass in the Framingham Heart Study by Suchindran, Sunil, Rivedal, David, Guyton, John R., Milledge, Tom, Gao, Xiaoyi, Benjamin, Ashlee, Rowell, Jennifer, Ginsburg, Geoffrey S., McCarthy, Jeanette J.

“…Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of…”
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Clinical application of pharmacogenetics: focusing on practical issues by Chang, Matthew T, McCarthy, Jeanette J, Shin, Jaekyu

“…Recent large-scale genetic-based studies have transformed the field of pharmacogenetics to identify, characterize and leverage genetic information to inform…”
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Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C by Tillmann, Hans L, Patel, Keyur, Muir, Andrew J, Guy, Cynthia D, Li, Josephine H, Lao, Xiang Qian, Thompson, Alexander, Clark, Paul J, Gardner, Stephen D, McHutchison, John G, McCarthy, Jeanette J

“…Background & Aims IL28B polymorphisms have been associated with both treatment induced and spontaneous clearance of hepatitis C virus (HCV). We previously…”
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Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study by Suchindran, Sunil, Rivedal, David, Guyton, John R, Milledge, Tom, Gao, Xiaoyi, Benjamin, Ashlee, Rowell, Jennifer, Ginsburg, Geoffrey S, McCarthy, Jeanette J

“…Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of…”
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Personalized medicine: revolutionizing drug discovery and patient care by Ginsburg, Geoffrey S., McCarthy, Jeanette J.

“…Advances in human genome research are opening the door to a new paradigm for practising medicine that promises to transform healthcare. Personalized medicine,…”
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Toward clinical genomics in everyday medicine: perspectives and recommendations by Delaney, Susan K, Hultner, Michael L, Jacob, Howard J, Ledbetter, David H, McCarthy, Jeanette J, Ball, Michael, Beckman, Kenneth B, Belmont, John W, Bloss, Cinnamon S, Christman, Michael F, Cosgrove, Andy, Damiani, Stephen A, Danis, Timothy, Delledonne, Massimo, Dougherty, Michael J, Dudley, Joel T, Faucett, W Andrew, Friedman, Jennifer R, Haase, David H, Hays, Tom S, Heilsberg, Stu, Huber, Jeff, Kaminsky, Leah, Ledbetter, Nikki, Lee, Warren H, Levin, Elissa, Libiger, Ondrej, Linderman, Michael, Love, Richard L, Magnus, David C, Martland, AnneMarie, McClure, Susan L, Megill, Scott E, Messier, Helen, Nussbaum, Robert L, Palaniappan, Latha, Patay, Bradley A, Popovich, Bradley W, Quackenbush, John, Savant, Mark J, Su, Michael M, Terry, Sharon F, Tucker, Steven, Wong, William T, Green, Robert C

“…Precision or personalized medicine through clinical genome and exome sequencing has been described by some as a revolution that could transform healthcare…”
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Reply to: “Favorable association between genetic polymorphisms near the IL28B gene and hepatic steatosis: Direct or indirect?” by Tillmann, Hans Ludger, McCarthy, Jeanette J

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High predictive accuracy of an unbiased proteomic profile for sustained virologic response in chronic hepatitis C patients by Patel, Keyur, Lucas, Joseph E., Thompson, J. Will, Dubois, Laura G., Tillmann, Hans L., Thompson, Alexander J., Uzarski, Diane, Califf, Robert M., Moseley, Martin A., Ginsburg, Geoffrey S., McHutchison, John G., McCarthy, Jeanette J.

“…Chronic hepatitis C (CHC) infection is a leading cause of endstage liver disease. Current standard‐of‐care (SOC) interferon‐based therapy results in sustained…”
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Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome by McCarthy, Jeanette J

“…Abstract Background Despite decades of research, the genetic basis of coronary heart disease and its metabolic risk factors is poorly understood. Few studies…”
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Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C by Cyr, Derek D, Lucas, Joseph E, Thompson, J Will, Patel, Keyur, Clark, Paul J, Thompson, Alexander, Tillmann, Hans L, McHutchison, John G, Moseley, M Arthur, McCarthy, Jeanette J

“…Polymorphisms near the IL28B gene (e.g. rs12979860) encoding interferon λ3 have recently been associated with both spontaneous clearance and treatment response…”
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Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels by Corsetti, James P, Ryan, Dan, Moss, Arthur J, McCarthy, Jeanette, Goldenberg, Ilan, Zareba, Wojciech, Sparks, Charles E

“…Few studies are available in human populations investigating involvement of vascular inflammation and oxidative stress-related dysfunctional transformation of…”
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A note from the editors by Ginsburg, Geoffrey S, McCarthy, Jeanette J, Patrinos, George P

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Driving personalized medicine forward: the who, what, when, and how of educating the health‐care workforce by McCarthy, Jeanette J.

“…First I will address the Who question. According to the American Board of Genetic Counselors, there are currently ~3500 certified genetic counselors in the US…”
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The effect of SNCA 3′ region on the levels of SNCA-112 splicing variant by McCarthy, Jeanette J., Linnertz, Colton, Saucier, Laura, Burke, James R., Hulette, Christine M., Welsh-Bohmer, Kathleen A., Chiba-Falek, Ornit

“…Genetic variability at the 3′ region of SNCA locus has been repeatedly associated with susceptibility to sporadic Parkinson’s disease (PD). Accumulated…”
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