Search Results - "McCarthy, James R"

Totally Endoscopic Robotic Mitral Valve Surgery by McCarthy, James R., RN, AS, CNOR, CRNFA, Guy, T. Sloane, MD, MBA

“…Abstract Mitral valve dysfunction can seriously impair patients’ lives and may require valve repair or replacement. Surgery can be performed using techniques…”
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Potent, Orally Active Corticotropin-Releasing Factor Receptor-1 Antagonists Containing a Tricyclic Pyrrolopyridine or Pyrazolopyridine Core by Dyck, Brian, Grigoriadis, Dimitri E, Gross, Raymond S, Guo, Zhiqiang, Haddach, Mustapha, Marinkovic, Dragan, McCarthy, James R, Moorjani, Manisha, Regan, Collin F, Saunders, John, Schwaebe, Michael K, Szabo, Tomas, Williams, John P, Zhang, Xiaohu, Bozigian, Haig, Chen, Ta Kung

“…Two new classes of tricyclic-based corticotropin-releasing factor (CRF1) receptor-1 antagonists were designed by constraining known 1H-pyrrolo[2,3-b]pyridine…”
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Design and synthesis of statine-containing BACE inhibitors by JINGDAN HU, CWI, Cynthia L, MCCARTHY, James R, SMILEY, David L, TIMM, David, ERICKSON, Jon A, MCGEE, James E, YANG, Hsiu-Chiung, MENDEL, David, MAY, Patrick C, SHAPIRO, Mike

“…Utilizing structure-based techniques and solid-phase synthesis, statine-based tetrapeptide BACE inhibitors were designed and synthesized using a heptapeptide…”
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Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors by ZORRILLA, Eric P, SCHULTEIS, Gery, ORMSBY, Amanda, KLAASSEN, Alwin, LING, Nicholas, MCCARTHY, James R, KOOB, George F, DE SOUZA, Errol B

“…Intracerebroventricular (i.c.v.) administration of corticotropin-releasing factor (CRF) biphasically affects performance in tests of learning and memory. In…”
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Mitsunobu Approach to the Synthesis of Optically Active α,α-Disubstituted Amino Acids by Green, Jonathan E, Bender, David M, Jackson, Stona, O’Donnell, Martin J, McCarthy, James R

“…Chiral tertiary α-hydroxy esters of known stereochemical configuration were transformed to α-azido esters by Mitsunobu reaction with HN3. Optimization of this…”
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Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences by Bueno, Ana B., Agejas, Javier, Broughton, Howard, Dally, Robert, Durham, Timothy B., Espinosa, Juan Félix, González, Rosario, Hahn, Patric J., Marcos, Alicia, Rodríguez, Ramón, Sanz, Gema, Soriano, José F., Timm, David, Vidal, Paloma, Yang, Hsiu-Chiung, McCarthy, James R.

“…NMR conformational analysis of a hydroxyethylamine peptide isostere developed as an aspartic protease inhibitor shows that it is a flexible architecture…”
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Design and Synthesis of a Series of Non-Peptide High-Affinity Human Corticotropin-Releasing Factor1 Receptor Antagonists by Chen, Dagnino, Raymond, De Souza, Errol B, Grigoriadis, Dimitri E, Huang, Charles Q, Kim, Kyung-Il, Liu, Zhengyu, Moran, Terry, Webb, Thomas R, Whitten, Jeffrey P, Xie, Yun Feng, McCarthy, James R

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Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists by Huang, Charles Q, Wilcoxen, Keith, McCarthy, James R, Haddach, Mustapha, Webb, Thomas R, Gu, Jian, Xie, Yun-Feng, Grigoriadis, Dimitri E, Chen, Chen

“…A series of 4-substituted 8-aryl-2-methylquinolines 4 was designed and synthesized as highly potent antagonists for the human CRF(1) receptor. This series of…”
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Synthesis, Crystallization, and Biological Evaluation of an Orally Active Prodrug of Gemcitabine by Bender, David M, Bao, Jingqi, Dantzig, Anne H, Diseroad, William D, Law, Kevin L, Magnus, Nicholas A, Peterson, Jeffrey A, Perkins, Everett J, Pu, Yangwei J, Reutzel-Edens, Susan M, Remick, David M, Starling, James J, Stephenson, Gregory A, Vaid, Radhe K, Zhang, Deyi, McCarthy, James R

“…The design, synthesis, and biological characterization of an orally active prodrug (3) of gemcitabine are described. Additionally, the identification of a…”
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Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylamino-pyrazolo[1,5-a] pyrimidine (NBI 30775/r121919) and structure-activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists by CHEN CHEN, WILCOXEN, Keith M, BOZIGIAN, Haig, GRIGORIADIS, Dimitri E, HUANG, Charles Q, XIE, Yun-Feng, MCCARTHY, James R, WEBB, Thomas R, ZHU, Yun-Fei, SAUNDERS, John, LIU, Xin-Jun, CHEN, Ta-Kung

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Inactivation of Ribonucleotide Reductase by (E)-2‘-Fluoromethylene-2‘-deoxycytidine 5‘-Diphosphate:  A Paradigm for Nucleotide Mechanism-Based Inhibitors by van der Donk, Wilfred A, Yu, Guixue, Silva, Domingos J, Stubbe, JoAnne, McCarthy, James R, Jarvi, Esa T, Matthews, Donald P, Resvick, Robert J, Wagner, Eugene

“…Ribonucleotide reductase (RDPR) from Escherichia coli catalyzes the conversion of nucleotides to deoxynucleotides and is composed of two homodimeric subunits: …”
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Cyclopropanecarboxylic Acid Esters as Potential Prodrugs with Enhanced Hydrolytic Stability by Bender, David M, Peterson, Jeffrey A, McCarthy, James R, Gunaydin, Hakan, Takano, Yu, Houk, K. N

“…Esters of cyclopropanecarboxylic acid demonstrate a substantial increase in stability under both acid- and base-catalyzed hydrolytic conditions. Comparison of…”
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Application of the Dakin−West Reaction for the Synthesis of Oxazole-Containing Dual PPARα/γ Agonists by Godfrey, Alexander G, Brooks, Dawn A, Hay, Lynne A, Peters, Mary, McCarthy, James R, Mitchell, David

“…An improved method for the preparation of a series of oxazole-containing dual PPARα/γ agonists is described. A synthetic sequence utilizing a Dakin−West…”
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Terminal difluoro olefin analogs of squalene are time-dependent inhibitors of squalene epoxidase by Moore, William R, Schatzman, Gerald L, Jarvi, Esa T, Gross, Raymond S, McCarthy, James R

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A tailored therapy for the metabolic syndrome: The dual peroxisome proliferator-activated receptor-α/γ agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models by ETGEN, Garret J, OLDHAM, Brian A, SHUKER, Anthony J, RITO, Christopher J, MCCARTHY, James R, ARDECKY, Robert J, TYHONAS, John S, DANA, Sharon L, BILAKOVICS, James M, PATERNITI, James R, OGILVIE, Kathleen M, SHA LIU, JOHNSON, William T, KAUFFMAN, Raymond F, BRODERICK, Carol L, MONTROSE, Chahrzad R, BROZINICK, Joseph T, MISENER, Elizabeth A, BEAN, James S, BENSCH, William R, BROOKS, Dawn A

“…A novel nonthiazolidinedione dual peroxisome proliferator- activated receptor (PPAR)-alpha/gamma agonist, LY465608, was designed to address the major metabolic…”
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Macrocyclic peptidomimetic inhibitors of β-secretase (BACE): First X-ray structure of a macrocyclic peptidomimetic-BACE complex by Rojo, Isabel, Martín, José Alfredo, Broughton, Howard, Timm, David, Erickson, Jon, Yang, Hsiu-Chiung, McCarthy, James R.

“…The synthesis of novel macrocyclic peptidomimetic inhibitors of BACE1 is described. These macrocycles are derived from a hydroxyethylene core structure…”
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Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility by CHEN CHEN, WILCOXEN, Keith M, HUANG, Charles Q, MCCARTHY, James R, CHEN, Takung, GRIGORIADIS, Dimitri E

“…In our efforts to identify potent CRF(1) antagonists with proper physicochemical properties, a series of 3-phenylpyrazolo[1,5-a]pyrimidines bearing polar…”
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A convenient synthesis of the antibacterial agent linezolid by McCarthy, James R.

“…[Display omitted] Starting with 3,4-difluorobenzoic acid (8) and (S)-epichlorohydrin (13) a convergent synthesis of linezolid (1) was developed that is…”
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Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists by HUANG, Charles Q, WILCOXEN, Keith M, GRIGORIADIS, Dimitri E, MCCARTHY, James R, CHEN CHEN

“…A series of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines was designed and synthesized as antagonists for the corticotrophin-releasing factor-1 (CRF(1)) receptor…”
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Rational Design, Synthesis, and Structure−Activity Relationships of Aryltriazoles as Novel Corticotropin-Releasing Factor-1 Receptor Antagonists by Lowe, Richard F, Nelson, Jodene, Dang, Trunghau N, Crowe, Paul D, Pahuja, Anil, McCarthy, James R, Grigoriadis, Dimitri E, Conlon, Paul, Saunders, John, Chen, Chen, Szabo, Thomas, Chen, Ta Kung, Bozigian, Haig

“…Following the discovery of the very high binding affinity of 4-anilinopyrimidines against corticotropin-releasing factor receptor-1 (CRF1) (e.g., 1, K i = 2…”
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