Search Results - "McCarthy, Cathal M."

The biology of ergothioneine, an antioxidant nutraceutical by Borodina, Irina, Kenny, Louise C., McCarthy, Cathal M., Paramasivan, Kalaivani, Pretorius, Etheresia, Roberts, Timothy J., van der Hoek, Steven A., Kell, Douglas B.

“…Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent antioxidant activities. It is synthesised by a variety of microbes,…”
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Gestational Diabetes Mellitus and Maternal Immune Dysregulation: What We Know So Far by McElwain, Colm J, McCarthy, Fergus P, McCarthy, Cathal M

“…Gestational diabetes mellitus (GDM) is an obstetric complication that affects approximately 5-10% of all pregnancies worldwide. GDM is defined as any degree of…”
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Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health? by McElwain, Colm J, Tuboly, Eszter, McCarthy, Fergus P, McCarthy, Cathal M

“…Placental insufficiency and adipose tissue dysregulation are postulated to play key roles in the pathophysiology of both pre-eclampsia (PE) and gestational…”
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sFlt-1 impairs neurite growth and neuronal differentiation in SH-SY5Y cells and human neurons by Barron, Aaron, Barrett, Lauren, Tuulari, Jetro J, Karlsson, Linnea, Karlsson, Hasse, McCarthy, Cathal M, O'Keeffe, Gerard W

“…Pre-eclampsia (PE) is a hypertensive disorder of pregnancy which is associated with increased risk of neurodevelopmental disorders in exposed offspring. The…”
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An altered gut microbiome in pre-eclampsia: cause or consequence by Deady, Clara, McCarthy, Fergus P, Barron, Aaron, McCarthy, Cathal M, O'Keeffe, Gerard W, O'Mahony, Siobhain M

“…Hypertensive disorders of pregnancy, including pre-eclampsia, are a leading cause of serious and debilitating complications that affect both the mother and the…”
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Preeclampsia and Neurodevelopmental Outcomes: Potential Pathogenic Roles for Inflammation and Oxidative Stress? by Barron, Aaron, McCarthy, Cathal M., O’Keeffe, Gerard W.

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Maternal pre-eclampsia serum increases neurite growth and mitochondrial function through a potential IL-6-dependent mechanism in differentiated SH-SY5Y cells by Barron, Aaron, Manna, Samprikta, McElwain, Colm J, Musumeci, Andrea, McCarthy, Fergus P, O'Keeffe, Gerard W, McCarthy, Cathal M

“…Pre-eclampsia (PE) is a common and serious hypertensive disorder of pregnancy, which affects 3%-5% of first-time pregnancies and is a leading cause of maternal…”
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Preeclampsia and Neurodevelopmental Outcomes: Potential Pathogenic Roles for Inflammation and Oxidative Stress? by Barron, Aaron, McCarthy, Cathal M., O’Keeffe, Gerard W.

“…Preeclampsia (PE) is a common and serious hypertensive disorder of pregnancy that occurs in approximately 3–5% of first-time pregnancies and is a well-known…”
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Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator by McElwain, Colm, McCarthy, Cathal M.

“…Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance which is diagnosed during pregnancy and poses considerable health risks for…”
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L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model by Williamson, Rachel D., McCarthy, Fergus P., Manna, Samprikta, Groarke, Emer, Kell, Douglas B., Kenny, Louise C., McCarthy, Cathal M.

“…Preeclampsia is a multifactorial hypertensive disorder of pregnancy founded on abnormal placentation, and the resultant placental ischemic microenvironment is…”
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Activation of a TLR9 mediated innate immune response in preeclampsia by Williamson, Rachel D., McCarthy, Fergus P., Kenny, Louise C., McCarthy, Cathal M.

“…Preeclampsia is a multisystemic disorder leading to the development of a placental ischemic microenvironment with a resultant increase in oxidative stress…”
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Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus by McElwain, Colm J, Manna, Samprikta, Musumeci, Andrea, Sylvester, Isaac, Rouchon, Chloé, O'Callaghan, Anne Marie, Ebad, Mustafa Abdalla Bakhit, McCarthy, Fergus P, McCarthy, Cathal M

“…Gestational diabetes mellitus (GDM) is a complex obstetric condition affecting localized glucose metabolism, resulting in systemic metabolic dysfunction. This…”
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L-ergothioneine reduces mitochondrial-driven NLRP3 activation in gestational diabetes mellitus by McElwain, Colm J, Musumeci, Andrea, Manna, Samprikta, McCarthy, Fergus P, McCarthy, Cathal M

“…Maternal hyperglycaemia has a significant impact on placental metabolism and mitochondrial function. The NLRP3 inflammasome is responsive to endogenous signals…”
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Human α‐synuclein overexpression upregulates SKOR1 in a rat model of simulated nigrostriatal ageing by Morales‐Prieto, Noelia, Bevans, Rebekah, O'Mahony, Adam, Barron, Aaron, Giles Doran, Conor, McCarthy, Erin, Concannon, Ruth M., Goulding, Susan R., McCarthy, Cathal M., Collins, Louise M., Sullivan, Aideen M., O'Keeffe, Gerard W.

“…Parkinson's disease (PD) is characterised by progressive loss of dopaminergic (DA) neurons from the substantia nigra (SN) and α‐synuclein (αSyn) accumulation…”
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Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells by McCarthy, Erin, Barron, Aaron, Morales-Prieto, Noelia, Mazzocchi, Martina, McCarthy, Cathal M., Collins, Louise M., Sullivan, Aideen M., O’Keeffe, Gerard W.

“…Parkinson’s disease (PD) is neurodegenerative disorder with the pathological hallmarks of progressive degeneration of midbrain dopaminergic neurons from the…”
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NME1 Protects Against Neurotoxin-, α-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson’s Disease by Anantha, Jayanth, Goulding, Susan R., Tuboly, Eszter, O’Mahony, Adam G., Moloney, Gerard M., Lomansey, Gareth, McCarthy, Cathal M., Collins, Louise M., Sullivan, Aideen M., O’Keeffe, Gerard W.

“…Parkinson’s disease (PD) is a neurodegenerative disease characterised by the progressive degeneration of midbrain dopaminergic neurons, coupled with the…”
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A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: Does maternal inflammation play a role? by Maher, Gillian M., McCarthy, Fergus P., McCarthy, Cathal M., Kenny, Louise C., Kearney, Patricia M., Khashan, Ali S., O’Keeffe, Gerard W.

“…•Pre-eclampsia is a leading cause of maternal and perinatal morbidity.•Maternal inflammation is recognised as a core clinical feature of…”
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4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells by Sullivan, Aideen M., McCarthy, Cathal M., Hegarty, Shane V., Tuboly, Eszter, Alshangiti, Amnah M., O’Keeffe, Gerard W.

“…Neuroblastoma is an embryonal malignancy that arises from cells of sympathoadrenal lineage during the development of the nervous system. It is the most common…”
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Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction by Manna, Samprikta, McCarthy, Fergus P., McCarthy, Cathal M.

“…Preeclampsia is a multisystemic pregnancy disorder and a major cause of maternal and neonatal morbidity and mortality worldwide. The exact pathophysiology of…”
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Evidence of tissue specific alterations in inflammatory profiles in Gestational Diabetes Mellitus by McCarthy, Cathal M., McElwain, Colm J., Musumeci, Andrea, McCarthy, Fergus P.

“…Gestational diabetes mellitus (GDM) is defined as significant glucose intolerance first diagnosed in pregnancy. GDM develops due to exaggerated insulin…”
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