Search Results - "McCarthy, Brian P"

Characterization of 11C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation by Territo, Paul R, Meyer, Jill A, Peters, Jonathan S, Riley, Amanda A, McCarthy, Brian P, Gao, Mingzhang, Wang, Min, Green, Mark A, Zheng, Qi-Huang, Hutchins, Gary D

“…The purinergic receptor subtype 7 (P2X7R) represents a novel molecular target for imaging neuroinflammation via PET. GSK1482160, a potent P2X7R antagonist, has…”
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EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming by Adelaiye-Ogala, Remi, Budka, Justin, Damayanti, Nur P, Arrington, Justine, Ferris, Mary, Hsu, Chuan-Chih, Chintala, Sreenivasulu, Orillion, Ashley, Miles, Kiersten Marie, Shen, Li, Elbanna, May, Ciamporcero, Eric, Arisa, Sreevani, Pettazzoni, Piergiorgio, Draetta, Giulio F, Seshadri, Mukund, Hancock, Bradley, Radovich, Milan, Kota, Janaiah, Buck, Michael, Keilhack, Heike, McCarthy, Brian P, Persohn, Scott A, Territo, Paul R, Zang, Yong, Irudayaraj, Joseph, Tao, W Andy, Hollenhorst, Peter, Pili, Roberto

“…Acquired and intrinsic resistance to receptor tyrosine kinase inhibitors (RTKi) represents a major hurdle in improving the management of clear cell renal cell…”
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Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition by Neto-Neves, Evandro M, Brown, Mary B, Zaretskaia, Maria V, Rezania, Samin, Goodwill, Adam G, McCarthy, Brian P, Persohn, Scott A, Territo, Paul R, Kline, Jeffrey A

“…Our understanding of the pathophysiological basis of chronic thromboembolic pulmonary hypertension (CTEPH) will be accelerated by an animal model that…”
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Multimodality imaging methods for assessing retinoblastoma orthotopic xenograft growth and development by Corson, Timothy W, Samuels, Brian C, Wenzel, Andrea A, Geary, Anna J, Riley, Amanda A, McCarthy, Brian P, Hanenberg, Helmut, Bailey, Barbara J, Rogers, Pamela I, Pollok, Karen E, Rajashekhar, Gangaraju, Territo, Paul R

“…Genomic studies of the pediatric ocular tumor retinoblastoma are paving the way for development of targeted therapies. Robust model systems such as orthotopic…”
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Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney by Hato, Takashi, Friedman, Allon N, Mang, Henry, Plotkin, Zoya, Dube, Shataakshi, Hutchins, Gary D, Territo, Paul R, McCarthy, Brian P, Riley, Amanda A, Pichumani, Kumar, Malloy, Craig R, Harris, Robert A, Dagher, Pierre C, Sutton, Timothy A

“…The metabolic status of the kidney is a determinant of injury susceptibility and a measure of progression for many disease processes; however, noninvasive…”
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Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice by Brandt, Stephanie L, Klopfenstein, Nathan, Wang, Soujuan, Winfree, Seth, McCarthy, Brian P, Territo, Paul R, Miller, Lloyd, Serezani, C Henrique

“…The early events that shape the innate immune response to restrain pathogens during skin infections remain elusive. Methicillin-resistant Staphylococcus aureus…”
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Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model by Allen, Matthew R, McNerny, Erin, Aref, Mohammad, Organ, Jason M, Newman, Christopher L, McGowan, Brian, Jang, Tim, Burr, David B, Brown, Drew M, Hammond, Max, Territo, Paul R, Lin, Chen, Persohn, Scott, Jiang, Lei, Riley, Amanda A, McCarthy, Brian P, Hutchins, Gary D, Wallace, Joseph M

“…A growing number of studies have investigated combination treatment as an approach to treat bone disease. The goal of this study was to investigate the…”
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Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL‐AD preclinical testing core study by Onos, Kristen D., Quinney, Sara K., Jones, David R., Masters, Andrea R., Pandey, Ravi, Keezer, Kelly J., Biesdorf, Carla, Metzger, Ingrid F., Meyers, Jill A., Peters, Johnathon, Persohn, Scott C., McCarthy, Brian P., Bedwell, Amanda A., Figueiredo, Lucas L., Cope, Zackary A., Sasner, Michael, Howell, Gareth R., Williams, Harriet M., Oblak, Adrian L., Lamb, Bruce T., Carter, Gregory W., Rizzo, Stacey J. Sukoff, Territo, Paul R.

“…Introduction Hyperexcitability and epileptiform activity are commonplace in Alzheimer's disease (AD) patients and associated with impaired cognitive function…”
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Measurement of cardiovascular function using a novel view-sharing PET reconstruction method and tracer kinetic analysis by Territo, Paul R., Riley, Amanda A., McCarthy, Brian P., Hutchins, Gary D.

“…Recent advancements in PET instrumentation have made the non-invasive assessment of cardiovascular function in small animals a reality. The majority of small…”
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Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice by Brandt, Stephanie L., Wang, Sue, Dejani, Naiara N., Klopfenstein, Nathan, Winfree, Seth, Filgueiras, Luciano, McCarthy, Brian P., Territo, Paul R., Serezani, C. Henrique

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Trajectory design for Saturnian Ocean Worlds orbiters using multidimensional Poincaré maps by Davis, Diane Craig, Phillips, Sean M., McCarthy, Brian P.

“…Missions based on low-energy orbits in the vicinity of planetary moons, such as Titan or Enceladus, involve significant end-to-end trajectory design challenges…”
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IL-4-stimulated NF-κB activity is required for Stat6 DNA binding by Thieu, Vivian T., Nguyen, Evelyn T., McCarthy, Brian P., Bruns, Heather A., Kapur, Reuben, Chang, Cheong‐Hee, Kaplan, Mark H.

“…IL‐4 is a critical cytokine in the regulation of immune responses. In B lymphocytes, IL‐4 signaling promotes the Stat6‐dependent cell surface expression of…”
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In Vivo UTE‐MRI Reveals Positive Effects of Raloxifene on Skeletal‐Bound Water in Skeletally Mature Beagle Dogs by Allen, Matthew R, Territo, Paul R, Lin, Chen, Persohn, Scott, Jiang, Lei, Riley, Amanda A, McCarthy, Brian P, Newman, Christopher L, Burr, David B, Hutchins, Gary D

“…ABSTRACT Raloxifene positively affects mechanical properties of the bone matrix in part through modification of skeletal‐bound water. The goal of this study…”
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The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation by Weber, Daniel J, Gracon, Adam S A, Ripsch, Matthew S, Fisher, Amanda J, Cheon, Bo M, Pandya, Pankita H, Vittal, Ragini, Capitano, Maegan L, Kim, Youngsong, Allette, Yohance M, Riley, Amanda A, McCarthy, Brian P, Territo, Paul R, Hutchins, Gary D, Broxmeyer, Hal E, Sandusky, George E, White, Fletcher A, Wilkes, David S

“…Traumatic brain injury (TBI) results in systemic inflammatory responses that affect the lung. This is especially critical in the setting of lung…”
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Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation by Territo, Paul R, Meyer, Jill A, Peters, Jonathan S, Riley, Amanda A, McCarthy, Brian P, Gao, Mingzhang, Wang, Min, Green, Mark A, Zheng, Qi-Huang, Hutchins, Gary D

“…The purinergic receptor subtype 7 (P2X7R) represents a novel molecular target for imaging neuroinflammation via PET. GSK1482160, a potent P2X7R antagonist, has…”
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An Alternate Pathway for CD4 T Cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T Cell Population by Li, Wei, Kim, Moon-Gyo, Gourley, Tania S., McCarthy, Brian P., Sant’Angelo, Derek B., Chang, Cheong-Hee

“…Conventional understanding of CD4 T cell development is that the MHC class II molecules on cortical thymic epithelial cell are necessary for positive…”
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Longitudinal Bioluminescence Imaging of Primary Versus Abdominal Metastatic Tumor Growth in Orthotopic Pancreatic Tumor Models in NSG Mice by Shannon, Harlan E, Fishel, Melissa L, Xie, Jingwu, Gu, Dongsheng, McCarthy, Brian P, Riley, Amanda A, Sinn, Anthony L, Silver, Jayne M, Peterman, Kacie, Kelley, Mark R, Hanenberg, Helmut, Korc, Murray, Pollok, Karen E, Territo, Paul R

“…The purpose of the present study was to develop and validate noninvasive bioluminescence imaging methods for differentially monitoring primary and abdominal…”
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Evaluation of 11C-acetate and 18F-FDG PET/CT in mouse multidrug resistance gene-2 deficient mouse model of hepatocellular carcinoma by Territo, Paul R, Maluccio, Mary, Riley, Amanda A, McCarthy, Brian P, Fletcher, James, Tann, Mark, Saxena, Romil, Skill, Nicholas J

“…Hepatocellular carcinoma (HCC) remains a global health problem with unique diagnostic and therapeutic challenges, including difficulties in identifying the…”
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Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice by Brandt, Stephanie L, Wang, Sue, Dejani, Naiara N, Klopfenstein, Nathan, Winfree, Seth, Filgueiras, Luciano, McCarthy, Brian P, Territo, Paul R, Serezani, C Henrique

“…Poorly controlled diabetes leads to comorbidities and enhanced susceptibility to infections. While the immune components involved in wound healing in diabetes…”
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Thymic selection pathway regulates the effector function of CD4 T cells by Li, Wei, Sofi, M Hanief, Yeh, Norman, Sehra, Sarita, McCarthy, Brian P, Patel, Dipak R, Brutkiewicz, Randy R, Kaplan, Mark H, Chang, Cheong-Hee

“…Recently, a new developmental pathway for CD4 T cells that is mediated by major histocompatibility complex class II-positive thymocytes was identified (Choi,…”
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