Search Results - "McCarter, Roger"

Frailty Consensus: A Call to Action by Morley, John E., MB, BCh, Vellas, Bruno, MD, Abellan van Kan, G., MD, Anker, Stefan D., MD, PhD, Bauer, Juergen M., MD, PhD, Bernabei, Roberto, MD, Cesari, Matteo, MD, PhD, Chumlea, W.C., PhD, Doehner, Wolfram, MD, PhD, Evans, Jonathan, MD, Fried, Linda P., MD, MPH, Guralnik, Jack M., MD, PhD, Katz, Paul R., MD, CMD, Malmstrom, Theodore K., PhD, McCarter, Roger J., PhD, Gutierrez Robledo, Luis M., MD, PhD, Rockwood, Ken, MD, von Haehling, Stephan, MD, PhD, Vandewoude, Maurits F., MD, PhD, Walston, Jeremy, MD

“…Abstract Frailty is a clinical state in which there is an increase in an individual’s vulnerability for developing increased dependency and/or mortality when…”
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Significant life extension by ten percent dietary restriction by Richardson, Arlan, Austad, Steven N., Ikeno, Yuji, Unnikrishnan, Archana, McCarter, Roger J.

“…Although it is well documented that dietary restriction (DR) increases the life span of rodents and other animals, this increase is observed at relatively high…”
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In Memory: Edward J. Masoro, PhD (1924–2020) by Nelson, James F, Bhat, Manzoor, Herlihy, Jeremiah T, Ikeno, Yuji, Johnson, John M, Katz, Michael S, Levinson, Charles, Lichtenstein, Michael, Musi, Nicholas, McCarter, Roger J

“…An obituary for Edward J. Masoro, a pioneer in research on the biology of aging, who died on Jul 11, 2020 at the age of 95 is presented. Masoro played a key…”
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Association of Ghrelin Receptor Promoter Polymorphisms with Weight Loss Following Roux-en-Y Gastric Bypass Surgery by Matzko, Michelle E., Argyropoulos, George, Wood, G. Craig, Chu, Xin, McCarter, Roger J. M., Still, Christopher D., Gerhard, Glenn S.

“…Background Ghrelin plays a role in appetite and has been hypothesized to play a role in the mechanism of Roux-en-Y gastric bypass (RYGB) surgery. Single…”
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Time to Talk SENS: Critiquing the Immutability of Human Aging by DE GREY, AUBREY D. N. J., AMES, BRUCE N., ANDERSEN, JULIE K., BARTKE, ANDRZEJ, CAMPISI, JUDITH, HEWARD, CHRISTOPHER B., McCARTER, ROGER J. M., STOCK, GREGORY

“…Aging is a three‐stage process: metabolism, damage, and pathology. The biochemical processes that sustain life generate toxins as an intrinsic side effect…”
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Long-term IGF-I exposure decreases autophagy and cell viability by Bitto, Alessandro, Lerner, Chad, Torres, Claudio, Roell, Michaela, Malaguti, Marco, Perez, Viviana, Lorenzini, Antonello, Hrelia, Silvana, Ikeno, Yuji, Matzko, Michelle Elizabeth, McCarter, Roger, Sell, Christian

“…A reduction in IGF-I signaling has been found to increase lifespan in multiple organisms despite the fact that IGF-I is a trophic factor for many cell types…”
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Bioactive growth hormone in older men and women: It's relationship to immune markers and healthspan by Kraemer, William J, Kennett, Mary J, Mastro, Andrea M, McCarter, Roger J, Rogers, Connie J, DuPont, William H, Flanagan, Shawn D, Turbitt, William J, Fragala, Maren S, Post, Emily M, Hymer, Wesley C

“…Abstract Objective The consequences of age-related decline in the somatotropic axis of humans are complex and remain largely unresolved. We tested the…”
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Tissue specific and non-specific changes in gene expression by aging and by early stage CR by Fu, Chunxiao, Hickey, Morgen, Morrison, Melissa, McCarter, Roger, Han, Eun-Soo

“…Aging alters the expression of a variety of genes. Calorie restriction (CR), which extends life span in laboratory rodents, also changes gene expression. This…”
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The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C mice by Bhattacharya, Arunabh, Rahman, Md Mizanur, Sun, Dongxu, Lawrence, Richard, Mejia, Walter, McCarter, Roger, O'Shea, Marianne, Fernandes, Gabriel

“…Nearly half of the U.S. adult population is overweight or obese, which may be related to increased energy intake combined with lack of physical activity…”
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Heterogeneous Stocks and Selective Breeding in Aging Research by McClearn, Gerald E., McCarter, Roger J.

“…There are advantages and limitations to using genetically heterogeneous stocks and selective breeding procedures in gerontological and healthspan research…”
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Effects of Fiber Type on Ischemia-Reperfusion Injury in Mouse Skeletal Muscle by Woitaske, Melanie D, McCarter, Roger J. M

“…Tourniquets frequently used during surgery involve tissue ischemia followed by postoperative reperfusion. However, little information is available on the…”
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Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity by Tsao, T S, Li, J, Chang, K S, Stenbit, A E, Galuska, D, Anderson, J E, Zierath, J R, McCarter, R J, Charron, M J

“…To understand the long-term metabolic and functional consequences of increased GLUT4 content, intracellular substrate utilization was investigated in isolated…”
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Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span by Lorenzini, Antonello, Salmon, Adam B, Lerner, Chad, Torres, Claudio, Ikeno, Yuji, Motch, Susan, McCarter, Roger, Sell, Christian

“…Reduced signaling through the IGF type 1 (IGF-1) receptor increases life span in multiple invertebrate organisms. Studies on mammalian longevity suggest that…”
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Significant life extension by 10% dietary restriction by Richardson, Arlan, Austad, Steven N., Ikeno, Yuji, Unnikrishnan, Archana, McCarter, Roger J.

“…Although it is well documented that dietary restriction (DR) increases the lifespan of rodents and other animals, this increase is observed at relatively high…”
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Differential expression of muscular dystrophy in diaphragm versus hindlimb muscles of mdx mice by Dupont-Versteegden, E E, McCarter, R J

“…Contractile properties of diaphragm (DIA) from mdx and control mice were compared with those of hindlimb muscles [soleus (SOL) and extensor digitorum longus…”
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Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I by Salmon, Adam B, Lerner, Chad, Ikeno, Yuji, Motch Perrine, Susan M, McCarter, Roger, Sell, Christian

“…The extension of lifespan due to reduced insulin-like growth factor 1 (IGF-I) signaling in mice has been proposed to be mediated through alterations in…”
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Single muscle fiber discharge transformations: Fibrillation potential to positive sharp wave by Dumitru, Daniel, King, John C., McCarter, Roger J.M.

“…It is presently believed that a fibrillation potential (FP) can transform into a positive sharp wave (PSW) by displaying a number of individual transitional…”
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Effects of lifelong decreased IGF‐1 on physiological status in mice by Motch, Susan Marie, Sell, Christian, Graboski, Robyn, Matzko, Michelle, Stout, Joseph Tobias, McCarter, Roger

“…Caloric restriction (CR) and repression of the GH/IGF‐1/insulin signaling pathway increase lifespan, possibly via common genetic mechanisms of IGF‐1 regulation…”
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Plasma Glucose and the Action of Calorie Restriction on Aging by McCarter, Roger, Mejia, Walter, Ikeno, Yuji, Monnier, Vincent, Kewitt, Kristen, Gibbs, Michael, McMahan, Alex, Strong, Randy

“…We tested the hypothesis that retardation of aging by caloric restriction is due in part to decreased levels of plasma glucose over the life span. Male C57BL/6…”
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Reproducibility, Sources of Variability, Pooling, and Sample Size: Important Considerations for the Design of High-Density Oligonucleotide Array Experiments by Han, Eun-Soo, Wu, Yimin, McCarter, Roger, Nelson, James F., Richardson, Arlan, Hilsenbeck, Susan G.

“…We have undertaken a series of experiments to examine several issues that directly affect design of gene expression studies using Affymetrix GeneChip arrays:…”
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