Search Results - "McCarroll, Steve"

The genomic psychiatry cohort: Partners in discovery by Pato, Michele T., Sobell, Janet L., Medeiros, Helena, Abbott, Colony, Sklar, Brooke M., Buckley, Peter F., Bromet, Evelyn J., Escamilla, Michael A., Fanous, Ayman H., Lehrer, Douglas S., Macciardi, Fabio, Malaspina, Dolores, McCarroll, Steve A., Marder, Stephen R., Moran, Jennifer, Morley, Christopher P., Nicolini, Humberto, Perkins, Diana O., Purcell, Shaun M., Rapaport, Mark H., Sklar, Pamela, Smoller, Jordan W., Knowles, James A., Pato, Carlos N.

“…The Genomic Psychiatry Cohort (GPC) is a longitudinal resource designed to provide the necessary population‐based sample for large‐scale genomic studies,…”
Get full text

Variation and taphonomic implications of composition in modern and fossil malacostracan cuticles (Decapoda: Malacostraca) by Plotnick, Roy E, McCarroll, Steve

“…Abstract The crustacean fossil record is dominated by mineralized forms. These fossils, in turn, are mainly decapod chelae or parts of chelae. Studies of the…”
Get full text

41. CHARACTERIZING FUNCTIONAL CONVERGENCE OF COMMON POLYGENIC VARIATION IN NEUROPSYCHIATRIC DISORDER RISK GENES by Kuo, Susan, Weiner, Daniel, Ling, Emi, Fu, Jack, Satterstrom, F. Kyle, Talkowski, Michael, McCarroll, Steve, Robinson, Elise

“…Among neuropsychiatric disorders (NPDs), autism (ASD) and schizophrenia (SCZ) share both common and rare genetic variation that overlap with the etiology of…”
Get full text

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders by Singh, Tarjinder, Kurki, Mitja I, Curtis, David, Purcell, Shaun M, Crooks, Lucy, McRae, Jeremy, Suvisaari, Jaana, Chheda, Himanshu, Blackwood, Douglas, Breen, Gerome, Pietiläinen, Olli, Gerety, Sebastian S, Ayub, Muhammad, Blyth, Moira, Cole, Trevor, Collier, David, Coomber, Eve L, Craddock, Nick, Daly, Mark J, Danesh, John, DiForti, Marta, Foster, Alison, Freimer, Nelson B, Geschwind, Daniel, Johnstone, Mandy, Joss, Shelagh, Kirov, Georg, Körkkö, Jarmo, Kuismin, Outi, Holmans, Peter, Hultman, Christina M, Iyegbe, Conrad, Lönnqvist, Jouko, Männikkö, Minna, McCarroll, Steve A, McGuffin, Peter, McIntosh, Andrew M, McQuillin, Andrew, Moilanen, Jukka S, Moore, Carmel, Murray, Robin M, Newbury-Ecob, Ruth, Ouwehand, Willem, Paunio, Tiina, Prigmore, Elena, Rees, Elliott, Roberts, David, Sambrook, Jennifer, Sklar, Pamela, Clair, David St, Veijola, Juha, Walters, James T R, Williams, Hywel, Sullivan, Patrick F, Hurles, Matthew E, O'Donovan, Michael C, Palotie, Aarno, Owen, Michael J, Barrett, Jeffrey C

“…The authors analyzed the whole-exome sequences of over 16,000 individuals and found that very rare variants predicted to disrupt the SETD1A gene confer…”
Get full text

Role of complement C4A in developmental synaptic pruning by Presumey, Jessy, Bialas, Allison, Stevens, Beth, McCarroll, Steve, Carroll, Michael

Get full text

T30. LEVERAGING WHOLE GENOME SEQUENCING OF FAMILIES TO DISCOVER RARE VARIANTS ASSOCIATED WITH BIPOLAR DISORDER by Kazemi, Hamed, Drake, John, Bigdeli, Tim, Bacanu, Silviu, Benke, Kelly, Maher, Brion, Pato, Michele, Knowles, James, McCarroll, Steve, Carvalho, Celia, Medeiros, Helena, Ferreira, Rute, Vladimirov, Vladimir, Fanous, Ayman

“…Bipolar disorder, with a lifetime prevalence of 1%, is a common and debilitating mental illness with a significant socio-economic and health burden. Both…”
Get full text

30. IDENTIFICATION OF HUB GENES INVOLVED IN EARLY-ONSET SCHIZOPHRENIA USING GENETICALLY PREDICTED REGULATED GENE-EXPRESSION RISK SCORE FOR SCHIZOPHRENIA by Jen, Yawen, Yu, Sung-Liang, Hsiao, Po-Chang, Liu, Chih-Min, Liu, Chen-Chung, Hwang, Tzung-Jeng, Hsieh, Ming H., Huang, Hailiang, Chandler, Sharon D., Faraone, Stephen, Neale, Benjamin, McCarroll, Steve, Tsuang, Ming T., Hwu, Hai-Gwo, Chen, Wei J.

“…Genome-wide association studies (GWAS) have unveiled the polygenic architecture of schizophrenia (SZ). Early-onset SZ (EOS), a more homogeneous SZ subtype, may…”
Get full text

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities by Madison, J M, Zhou, F, Nigam, A, Hussain, A, Barker, D D, Nehme, R, van der Ven, K, Hsu, J, Wolf, P, Fleishman, M, O'Dushlaine, C, Rose, S, Chambert, K, Lau, F H, Ahfeldt, T, Rueckert, E H, Sheridan, S D, Fass, D M, Nemesh, J, Mullen, T E, Daheron, L, McCarroll, S, Sklar, P, Perlis, R H, Haggarty, S J

“…Bipolar disorder (BD) is a common neuropsychiatric disorder characterized by chronic recurrent episodes of depression and mania. Despite evidence for high…”
Get full text

STATISTICAL AND FUNCTIONAL CONVERGENCE OF COMMON AND RARE VARIANT RISK FOR AUTISM SPECTRUM DISORDERS AT CHROMOSOME 16P by Weiner, Daniel, Ling, Emi, Erdin, Serkan, Tai, Derek, Yadav, Rachita, Grove, Jakob, Fu, Jack, Nadig, Ajay, Sebat, Jonathan, O'Connor, Luke, Hougaard, David, Børglum, Anders, Talkowski, Michael, McCarroll, Steve, Robinson, Elise

Get full text

38. COMMON AND RARE GENETIC RISK FACTORS FOR SCHIZOPHRENIA AT CHROMOSOME 22Q INDUCE CONVERGENT, DISPERSED CHANGES IN GENE EXPRESSION by Nadig, Ajay, Tegtmeyer, Matthew, Weiner, Daniel J., Ling, Emi, Gordon, Aaron, O'Connor, Luke J., Aryee, Martin J., Bearden, Carrie E., Geschwind, Daniel, McCarroll, Steve A., Nehme, Ralda, Robinson, Elise B.

Get full text

Clonal hematopoiesis and risk of chronic liver disease by Wong, Waihay J., Emdin, Connor, Bick, Alexander G., Zekavat, Seyedeh M., Niroula, Abhishek, Pirruccello, James P., Dichtel, Laura, Griffin, Gabriel, Uddin, Md Mesbah, Gibson, Christopher J., Kovalcik, Veronica, Lin, Amy E., McConkey, Marie E, Vromman, Amelie, Sellar, Rob S., Kim, Peter G., Agrawal, Mridul, Weinstock, Joshua, Long, Michelle T., Yu, Bing, Banerjee, Rajarshi, Nicholls, Rowan C., Dennis, Andrea, Kelly, Matt, Loh, Po-Ru, McCarroll, Steve, Boerwinkle, Eric, Vasan, Ramachandran S., Jaiswal, Siddhartha, Johnson, Andrew D., Chung, Raymond T., Corey, Kathleen, Levy, Daniel, Ballantyne, Christie, Ebert, Benjain L., Natarajan, Pradeep

“…Chronic liver disease is a major public health burden worldwide 1 . Although different aetiologies and mechanisms of liver injury exist, progression of chronic…”
Get full text

A genome-wide association search for type 2 diabetes genes in African Americans by Palmer, Nicholette D, McDonough, Caitrin W, Hicks, Pamela J, Roh, Bong H, Wing, Maria R, An, S Sandy, Hester, Jessica M, Cooke, Jessica N, Bostrom, Meredith A, Rudock, Megan E, Talbert, Matthew E, Lewis, Joshua P, Ferrara, Assiamira, Lu, Lingyi, Ziegler, Julie T, Sale, Michele M, Divers, Jasmin, Shriner, Daniel, Adeyemo, Adebowale, Rotimi, Charles N, Ng, Maggie C Y, Langefeld, Carl D, Freedman, Barry I, Bowden, Donald W, Voight, Benjamin F, Scott, Laura J, Steinthorsdottir, Valgerdur, Morris, Andrew P, Dina, Christian, Welch, Ryan P, Zeggini, Eleftheria, Huth, Cornelia, Aulchenko, Yurii S, Thorleifsson, Gudmar, McCulloch, Laura J, Ferreira, Teresa, Grallert, Harald, Amin, Najaf, Wu, Guanming, Willer, Cristen J, Raychaudhuri, Soumya, McCarroll, Steve A, Langenberg, Claudia, Hofmann, Oliver M, Dupuis, Josée, Qi, Lu, Segrè, Ayellet V, van Hoek, Mandy, Navarro, Pau, Ardlie, Kristin, Balkau, Beverley, Benediktsson, Rafn, Bennett, Amanda J, Blagieva, Roza, Boerwinkle, Eric, Bonnycastle, Lori L, Boström, Kristina Bengtsson, Bravenboer, Bert, Bumpstead, Suzannah, Burtt, Noël P, Charpentier, Guillaume, Chines, Peter S, Cornelis, Marilyn, Couper, David J, Crawford, Gabe, Doney, Alex S F, Elliott, Katherine S, Elliott, Amanda L, Erdos, Michael R, Fox, Caroline S, Franklin, Christopher S, Ganser, Martha, Gieger, Christian, Grarup, Niels, Green, Todd, Griffin, Simon, Groves, Christopher J, Guiducci, Candace, Hadjadj, Samy, Hassanali, Neelam, Herder, Christian, Isomaa, Bo, Jackson, Anne U, Johnson, Paul R V, Jørgensen, Torben, Kao, Wen H L, Klopp, Norman, Kong, Augustine, Kraft, Peter, Kuusisto, Johanna, Lauritzen, Torsten, Li, Man, Lieverse, Aloysius, Lindgren, Cecilia M, Lyssenko, Valeriya, Marre, Michel, Meitinger, Thomas, Midthjell, Kristian, Morken, Mario A, Narisu, Narisu

“…African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this…”
Get full text

55 - LARGE META-ANALYSIS OF SCANDINAVIAN EXOME SEQUENCING STUDIES OF SCHIZOPHRENIA by Lescai, Francesco, Satterstrom, Kyle, Als, Thomas, Grove, Jakob, Maller, Jules, Grauholm, Jonas, Stevens, Christine, Walters, Raymond, Sullivan, Patrick, McCarroll, Steve, Hougaard, David, Werge, Thomas, Neale, Benjamin, Daly, Mark, Børglum, Anders

“…The current data indicated that the allelic architecture of complex traits is caused by many common and rare variants. Large GWAS meta-analyses have been…”
Get full text

LARGE META-ANALYSIS OF SCANDINAVIAN EXOME SEQUENCING STUDIES OF SCHIZOPHRENIA by Lescai, Francesco, Satterstrom, Kyle, Als, Thomas, Grove, Jakob, Maller, Jules, Grauholm, Jonas, Stevens, Christine, Walters, Raymond, Sullivan, Patrick, McCarroll, Steve, Hougaard, David, Werge, Thomas, Neale, Benjamin, Daly, Mark, Børglum, Anders

Get full text

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis by Voight, Benjamin F, Scott, Laura J, Morris, Andrew P, Dina, Christian, Welch, Ryan P, Zeggini, Eleftheria, Huth, Cornelia, Aulchenko, Yurii S, McCulloch, Laura J, Ferreira, Teresa, Grallert, Harald, Wu, Guanming, Raychaudhuri, Soumya, Langenberg, Claudia, Dupuis, Josée, Qi, Lu, Segrè, Ayellet V, van Hoek, Mandy, Navarro, Pau, Benediktsson, Rafn, Bonnycastle, Lori L, Charpentier, Guillaume, Cornelis, Marilyn, Couper, David J, Crawford, Gabe, Doney, Alex S F, Elliott, Amanda L, Erdos, Michael R, Grarup, Niels, Green, Todd, Groves, Christopher J, Guiducci, Candace, Hadjadj, Samy, Hassanali, Neelam, Isomaa, Bo, Johnson, Paul R V, Jørgensen, Torben, Kao, Wen H L, Klopp, Norman, Kong, Augustine, Kraft, Peter, Lauritzen, Torsten, Li, Man, Marre, Michel, Midthjell, Kristian, Morken, Mario A, Narisu, Narisu, Owen, Katharine R, Payne, Felicity, Perry, John R B, Petersen, Ann-Kristin, Platou, Carl, Proença, Christine, Prokopenko, Inga, Rathmann, Wolfgang, Rayner, N William, Rocheleau, Ghislain, Sampson, Michael J, Saxena, Richa, Shields, Beverley M, Shrader, Peter, Sigurdsson, Gunnar, Sparsø, Thomas, Stringham, Heather M, Sun, Qi, Swift, Amy J, Thorand, Barbara, Tichet, Jean, van Haeften, Timon W, van Herpt, Thijs, Walters, G Bragi, Weedon, Michael N, Wijmenga, Cisca, Witteman, Jacqueline, Bergman, Richard N, Cauchi, Stephane, Collins, Francis S, Gyllensten, Ulf, Hofman, Albert, Hunter, David J, Hveem, Kristian, Pramstaller, Peter P, Uitterlinden, Andre, Walker, Mark, Wareham, Nicholas J, Abecasis, Gonçalo R, Boehm, Bernhard O, Campbell, Harry, Daly, Mark J, Hu, Frank B, Meigs, James B, Pankow, James S, Pedersen, Oluf, Wichmann, H-Erich, Barroso, Inês, Florez, Jose C, Thorsteinsdottir, Unnur, Froguel, Philippe, van Duijn, Cornelia M, Stefansson, Kari

“…Mark McCarthy and colleagues identify twelve new risk loci for type 2 diabetes through a large-scale genome-wide association and replication study in…”
Get full text

M94. Genetic Analyses of Cognitive Performance in Psychotic Disorders From the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium by Bishop, Jeffrey, Hill, Scot, Mills, Lauren, Alliey-Rodriguez, Ney, Reilly, James, Shaffee, Rebecca, McCarroll, Steve, Keefe, Richard, Pearlson, Godfrey, Clementz, Brett, Tamminga, Carol, Keshavan, Matcheri, Gershon, Elliot, Sweeney, John

“…Background: Cognitive deficits are present and familial in psychotic disorders and understanding the genetic contributors to these impairments in patients as…”
Get full text

Genome-wide Comparison of African-Ancestry Populations from CARe and Other Cohorts Reveals Signals of Natural Selection by Bhatia, Gaurav, Patterson, Nick, Pasaniuc, Bogdan, Zaitlen, Noah, Genovese, Giulio, Pollack, Samuela, Mallick, Swapan, Myers, Simon, Tandon, Arti, Spencer, Chris, Palmer, Cameron D., Adeyemo, Adebowale A., Akylbekova, Ermeg L., Cupples, L. Adrienne, Divers, Jasmin, Fornage, Myriam, Kao, W.H. Linda, Lange, Leslie, Li, Mingyao, Musani, Solomon, Mychaleckyj, Josyf C., Ogunniyi, Adesola, Papanicolaou, George, Rotimi, Charles N., Rotter, Jerome I., Ruczinski, Ingo, Salako, Babatunde, Siscovick, David S., Tayo, Bamidele O., Yang, Qiong, McCarroll, Steve, Sabeti, Pardis, Lettre, Guillaume, De Jager, Phil, Hirschhorn, Joel, Zhu, Xiaofeng, Cooper, Richard, Reich, David, Wilson, James G., Price, Alkes L.

“…The study of recent natural selection in human populations has important applications to human history and medicine. Positive natural selection drives the…”
Get full text

Implication of LRRC4C and DPP6 in neurodevelopmental disorders by Maussion, Gilles, Cruceanu, Cristiana, Rosenfeld, Jill A., Bell, Scott C., Jollant, Fabrice, Szatkiewicz, Jin, Collins, Ryan L., Hanscom, Carrie, Kolobova, Ilaria, de Champfleur, Nicolas Menjot, Blumenthal, Ian, Chiang, Colby, Ota, Vanessa, Hultman, Christina, O'Dushlaine, Colm, McCarroll, Steve, Alda, Martin, Jacquemont, Sebastien, Ordulu, Zehra, Marshall, Christian R., Carter, Melissa T., Shaffer, Lisa G., Sklar, Pamela, Girirajan, Santhosh, Morton, Cynthia C., Gusella, James F., Turecki, Gustavo, Stavropoulos, Dimitri J., Sullivan, Patrick F., Scherer, Stephen W., Talkowski, Michael E., Ernst, Carl

“…We performed whole‐genome sequencing on an individual from a family with variable psychiatric phenotypes that had a sensory processing disorder, apraxia, and…”
Get full text

Genome-Wide Association Studies Of Smooth Pursuit Eye Movements Across Psychotic Disorders: Preliminary Findings From The B-Snip Sample by Lencer, Rebekka, Mills, Lauren J., Alliey-Rodriguez, Ney, Reilly, James L., Sprenger, Andreas, McDowell, Jennifer E., Keshavan, Matcheri S., Pearlson, Godfrey D., McCarroll, Steve, Tamminga, Carol A., Clementz, Brett A., Gershon, Elliot S., Sweeney, John A., Bishop, Jeffrey R.

“…Smooth pursuit eye movement dysfunctions are regarded as intermediate phenotypes for psychotic disorders. They include first, impairments of sensorimotor…”
Get full text

11. Extended Association Studies of Smooth Pursuit and Antisaccade Eye Movements: Findings From the B-SNIP Study by Lencer, Rebekka, Mills, Lauren J., Alliey-Rodriguez, Ney, Reilly, James L., Sprenger, Andreas, McDowell, Jennifer E., Shafee, Rebecca, McCarroll, Steve A., Keshavan, Matcheri S., Pearlson, Godfrey D., Tamminga, Carol A., Clementz, Brett A., Gershon, Elliot S., Sweeney, John A., Bishop, Jeffrey R.

“…Background: Eye movement dysfunctions represent well-established endophenotypes for psychotic disorders. They include impairments of sensorimotor processing,…”
Get full text