Search Results - "McCann, Una D"

The effects of sleep deprivation on pain inhibition and spontaneous pain in women by SMITH, Michael T, EDWARDS, Robert R, MCCANN, Una D, HAYTHORNTHWAITE, Jennifer A

“…Impaired central pain modulation is implicated in the pathophysiology of chronic pain. In this controlled experiment, we evaluated whether partial sleep loss…”
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Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users by McCann, Una D., Kuwabara, Hiroto, Kumar, Anil, Palermo, Michael, Abbey, Rubyna, Brasic, James, Ye, Weiguo, Alexander, Mohab, Dannals, Robert F., Wong, Dean F., Ricaurte, George A.

“…Background: Studies in abstinent methamphetamine (METH) users have demonstrated reductions in brain dopamine transporter (DAT) binding potential (BP), as well…”
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Studies of (±)-3,4-methylenedioxymethamphetamine (MDMA) metabolism and disposition in rats and mice: relationship to neuroprotection and neurotoxicity profile by Mueller, Melanie, Maldonado-Adrian, Concepcion, Yuan, Jie, McCann, Una D, Ricaurte, George A

“…The neurotoxicity of (±)-3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") is influenced by temperature and varies according to species. The mechanisms…”
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Further Studies on the Role of Metabolites in (±)-3,4-Methylenedioxymethamphetamine-Induced Serotonergic Neurotoxicity by Mueller, Melanie, Yuan, Jie, Felim, Anne, Neudörffer, Anne, Peters, Frank T, Maurer, Hans H, McCann, Una D, Largeron, Martine, Ricaurte, George A

“…The mechanism by which the recreational drug (±)-3,4-methylenedioxymethamphetamine (MDMA) destroys brain serotonin (5-HT) axon terminals is not understood…”
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Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its major metabolites in squirrel monkeys at plasma concentrations of MDMA that develop after typical psychoactive doses by Mueller, Melanie, Peters, Frank T, Maurer, Hans H, McCann, Una D, Ricaurte, George A

“…At certain doses, the psychoactive drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") destroys brain serotonin axon terminals. By causing increases…”
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Amphetamine treatment similar to that used in the treatment of adult attention-deficit/hyperactivity disorder damages dopaminergic nerve endings in the striatum of adult nonhuman primates by Ricaurte, George A, Mechan, Annis O, Yuan, Jie, Hatzidimitriou, George, Xie, Tao, Mayne, Andrew H, McCann, Una D

“…Pharmacotherapy with amphetamine is effective in the management of attention-deficit/hyperactivity disorder (ADHD), now recognized in adults as well as in…”
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Plasma Drug Concentrations and Physiological Measures in 'Dance Party' Participants by IRVINE, Rodney J, KEANE, Michael, FELGATE, Peter, MCCANN, Una D, CALLAGHAN, Paul D, WHITE, Jason M

“…The increasing use of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) in the setting of large dance parties ('raves') and clubs has been the source of some…”
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Platelet Serotonin Signaling in Patients With Cardiovascular Disease and Comorbid Depression by Williams, Marlene S, Ziegelstein, Roy C, McCann, Una D, Gould, Neda F, Ashvetiya, Tamara, Vaidya, Dhananjay

“…Depression in patients with cardiovascular disease is associated with increased risk of adverse clinical outcomes. Investigators have searched for potential…”
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Sleep disturbance and the effects of extended-release zolpidem during cannabis withdrawal by Vandrey, Ryan, Smith, Michael T, McCann, Una D, Budney, Alan J, Curran, Erin M

“…Abstract Background Sleep difficulty is a common symptom of cannabis withdrawal, but little research has objectively measured sleep or explored the effects of…”
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Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (±)3,4-methylenedioxymethamphetamine (“ecstasy”) users: relationship to cognitive performance by McCann, Una D., Szabo, Zsolt, Vranesic, Melin, Palermo, Michael, Mathews, William B., Ravert, Hayden T., Dannals, Robert F., Ricaurte, George A.

“…Background (±)3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) is a recreational drug and brain serotonin (5-HT) neurotoxin. Under certain conditions, MDMA…”
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3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"): pharmacology and toxicology in animals and humans by Steele, T D, McCann, U D, Ricaurte, G A

“…(+/-)3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"), a ring-substituted amphetamine derivative first synthesized in 1914, has emerged as a popular…”
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Recognition and management of complications of new recreational drug use by Ricaurte, George A, McCann, Una D

“…Use of illicit drugs in clubs and large dance parties (so-called raves) is a burgeoning cultural trend. Such recreational drug use is associated with several…”
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Quantitative PET Studies of the Serotonin Transporter in MDMA Users and Controls Using [ C]McN5652 and [ C]DASB by MCCANN, Una D, SZABO, Zsolt, SECKIN, Esen, ROSENBLATT, Peter, MATHEWS, William B, RAVERT, Hayden T, DANNALS, Robert F, RICAURTE, George A

“…(+/-)3,4-Methylenedioxymethamphetamine (MDMA, 'Ecstasy') is a widely used illicit drug that produces toxic effects on brain serotonin axons and axon terminals…”
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Effects of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) on sleep and circadian rhythms by McCann, Una D, Ricaurte, George A

“…Abuse of stimulant drugs invariably leads to a disruption in sleep-wake patterns by virtue of the arousing and sleep-preventing effects of these drugs. Certain…”
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Amphetamine neurotoxicity: accomplishments and remaining challenges by McCann, Una D, Ricaurte, George A

“…In addition to the social, cultural and indirect medical complications of amphetamine analog abuse, this class of drugs is also known to have the potential to…”
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Sleep apnea in young abstinent recreational MDMA (ecstasy) consumers by MCCANN, Una D, SGAMBATI, Francis P, SCHWARTZ, Alan R, RICAURTE, George A

“…Methylenedioxymethamphetamine (MDMA, "ecstasy") is a popular recreational drug of abuse and a selective brain serotonin neurotoxin. Functional consequences of…”
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Single oral doses of (±) 3,4-methylenedioxymethamphetamine (‘Ecstasy’) produce lasting serotonergic deficits in non-human primates: relationship to plasma drug and metabolite concentrations by Mueller, Melanie, Yuan, Jie, McCann, Una D., Hatzidimitriou, George, Ricaurte, George A.

“…Repeated doses of the popular recreational drug methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) are known to produce neurotoxic effects on brain serotonin…”
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Reduced Striatal Dopamine Transporter Density in Abstinent Methamphetamine and Methcathinone Users: Evidence from Positron Emission Tomography Studies with [11C]WIN-35,428 by McCann, Una D, Wong, Dean F, Yokoi, Fuji, Villemagne, Victor, Dannals, Robert F, Ricaurte, George A

“…Methamphetamine and methcathinone are psychostimulant drugs with high potential for abuse. In animals, methamphetamine and related drugs are known to damage…”
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Metabolism and disposition of 3,4-methylenedioxymethamphetamine ("ecstasy") in baboons after oral administration: comparison with humans reveals marked differences by Mueller, Melanie, Goodwin, Amy K, Ator, Nancy A, McCann, Una D, Ricaurte, George A

“…The baboon is potentially an attractive animal for modeling 3,4-methylenedioxymethamphetamine (MDMA) effects in humans. Baboons self-administer MDMA, are…”
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Altered Serotonin Innervation Patterns in the Forebrain of Monkeys Treated with (±)3,4-Methylenedioxymethamphetamine Seven Years Previously: Factors Influencing Abnormal Recovery by Hatzidimitriou, George, McCann, Una D, Ricaurte, George A

“…The recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") is a potent and selective brain serotonin (5-HT) neurotoxin in animals and,…”
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