Search Results - "McCann, Owen T"
-
1
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
Published in Genome research (01-04-2010)“…There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first genome-scale study of…”
Get full text
Journal Article -
2
Replication timing of the human genome
Published in Human molecular genetics (15-01-2004)“…We have developed a directly quantitative method utilizing genomic clone DNA microarrays to assess the replication timing of sequences during the S phase of…”
Get full text
Journal Article -
3
Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease
Published in Npj genomic medicine (04-05-2016)“…Ankylosing spondylitis (AS) is a common chronic immune-mediated arthropathy affecting primarily the spine and pelvis. The condition is strongly associated with…”
Get full text
Journal Article -
4
Finishing the finished human chromosome 22 sequence
Published in Genome biology (13-05-2008)“…Although the human genome sequence was declared complete in 2004, the sequence was interrupted by 341 gaps of which 308 lay in an estimated approximately 28 Mb…”
Get full text
Journal Article -
5
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Published in Nature genetics (01-10-2013)“…Patrick Sullivan and colleagues report a multi-stage genome-wide association study for schizophrenia in a Swedish population. They identify 13 loci newly…”
Get full text
Journal Article -
6
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Published in Nature (London) (11-08-2011)“…The genetics of multiple sclerosis Multiple sclerosis is a disease of the central nervous system that involves interplay between inflammation and…”
Get full text
Journal Article -
7
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
Published in Nature genetics (01-08-2011)“…Matthew Brown, Peter Donnelly and colleagues report results of a genome-wide association meta-analysis and follow-up study of ankylosing spondylitis. They…”
Get full text
Journal Article -
8
Replication timing of the human genome
Published in Human molecular genetics (01-03-2004)Get full text
Journal Article -
9
Multiple common variants for celiac disease influencing immune gene expression
Published in Nature genetics (01-04-2010)“…David van Heel and colleagues report results of a large genome-wide association study of celiac disease. Most of the associated loci contain genes with immune…”
Get full text
Journal Article -
10
A polygenic resilience score moderates the genetic risk for schizophrenia
Published in Molecular psychiatry (01-03-2021)“…Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531–538, 2016) of rare variants that confer resistance to Mendelian disease,…”
Get full text
Journal Article -
11
Variants in MTNR1B influence fasting glucose levels
Published in Nature genetics (01-01-2009)“…To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide…”
Get full text
Journal Article -
12
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
Published in Nature genetics (01-12-2009)“…Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we…”
Get full text
Journal Article -
13
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
Published in Nature communications (14-05-2018)“…Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide…”
Get full text
Journal Article -
14
GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level
Published in Gut (01-04-2023)“…Oesophageal cancer (EC) is the sixth leading cause of cancer-related deaths. Oesophageal adenocarcinoma (EA), with Barrett's oesophagus (BE) as a precursor…”
Get more information
Journal Article -
15
Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants
Published in Neurology (26-05-2015)“…OBJECTIVE:To quantify genetic overlap between migraine and ischemic stroke (IS) with respect to common genetic variation. METHODS:We applied 4 different…”
Get full text
Journal Article -
16
MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls
Published in Translational psychiatry (24-01-2017)“…Variants at microRNA-137 (MIR137) , one of the most strongly associated schizophrenia risk loci identified to date, have been associated with poorer cognitive…”
Get full text
Journal Article -
17
The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis
Published in Genes and immunity (01-01-2016)“…Acute anterior uveitis (AAU) involves inflammation of the iris and ciliary body of the eye. It occurs both in isolation and as a complication of ankylosing…”
Get full text
Journal Article -
18
Polygenic risk of ischemic stroke is associated with cognitive ability
Published in Neurology (16-02-2016)“…OBJECTIVES:We investigated the correlation between polygenic risk of ischemic stroke (and its subtypes) and cognitive ability in 3 relatively healthy Scottish…”
Get full text
Journal Article -
19
Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
Published in Nature communications (08-01-2019)“…Emmanuelle Souzeau, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this Article…”
Get full text
Journal Article -
20
A physical map of the human genome
Published in Nature (London) (15-02-2001)“…The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International…”
Get full text
Journal Article