Search Results - "McCann, Owen T"

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    Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains by Rakyan, Vardhman K, Down, Thomas A, Maslau, Siarhei, Andrew, Toby, Yang, Tsun-Po, Beyan, Huriya, Whittaker, Pamela, McCann, Owen T, Finer, Sarah, Valdes, Ana M, Leslie, R David, Deloukas, Panogiotis, Spector, Timothy D

    Published in Genome research (01-04-2010)
    “…There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first genome-scale study of…”
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    Replication timing of the human genome by Woodfine, Kathryn, Fiegler, Heike, Beare, David M., Collins, John E., McCann, Owen T., Young, Bryan D., Debernardi, Silvana, Mott, Richard, Dunham, Ian, Carter, Nigel P.

    Published in Human molecular genetics (15-01-2004)
    “…We have developed a directly quantitative method utilizing genomic clone DNA microarrays to assess the replication timing of sequences during the S phase of…”
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    Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease by Robinson, Philip C, Leo, Paul J, Pointon, Jennifer J, Harris, Jessica, Cremin, Katie, Bradbury, Linda A, Stebbings, Simon, Harrison, Andrew A, Duncan, Emma L, Evans, David M, Wordsworth, Paul B, Brown, Matthew A

    Published in Npj genomic medicine (04-05-2016)
    “…Ankylosing spondylitis (AS) is a common chronic immune-mediated arthropathy affecting primarily the spine and pelvis. The condition is strongly associated with…”
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    Finishing the finished human chromosome 22 sequence by Cole, Charlotte G, McCann, Owen T, Collins, John E, Oliver, Karen, Willey, David, Gribble, Susan M, Yang, Fengtang, McLaren, Karen, Rogers, Jane, Ning, Zemin, Beare, David M, Dunham, Ian

    Published in Genome biology (13-05-2008)
    “…Although the human genome sequence was declared complete in 2004, the sequence was interrupted by 341 gaps of which 308 lay in an estimated approximately 28 Mb…”
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    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis by Sawcer, Stephen, Hellenthal, Garrett, Pirinen, Matti, Spencer, Chris C A, Patsopoulos, Nikolaos A, Moutsianas, Loukas, Dilthey, Alexander, Su, Zhan, Freeman, Colin, Hunt, Sarah E, Edkins, Sarah, Gray, Emma, Booth, David R, Potter, Simon C, Goris, An, Band, Gavin, Oturai, Annette Bang, Strange, Amy, Saarela, Janna, Bellenguez, Céline, Fontaine, Bertrand, Gillman, Matthew, Hemmer, Bernhard, Gwilliam, Rhian, Zipp, Frauke, Jayakumar, Alagurevathi, Martin, Roland, Leslie, Stephen, Hawkins, Stanley, Giannoulatou, Eleni, D'alfonso, Sandra, Blackburn, Hannah, Martinelli Boneschi, Filippo, Liddle, Jennifer, Harbo, Hanne F, Perez, Marc L, Spurkland, Anne, Waller, Matthew J, Mycko, Marcin P, Ricketts, Michelle, Comabella, Manuel, Hammond, Naomi, Kockum, Ingrid, McCann, Owen T, Ban, Maria, Whittaker, Pamela, Kemppinen, Anu, Weston, Paul, Hawkins, Clive, Widaa, Sara, Zajicek, John, Dronov, Serge, Robertson, Neil, Bumpstead, Suzannah J, Barcellos, Lisa F, Ravindrarajah, Rathi, Abraham, Roby, Alfredsson, Lars, Ardlie, Kristin, Aubin, Cristin, Baker, Amie, Baker, Katharine, Baranzini, Sergio E, Bergamaschi, Laura, Bergamaschi, Roberto, Bernstein, Allan, Berthele, Achim, Boggild, Mike, Bradfield, Jonathan P, Brassat, David, Broadley, Simon A, Buck, Dorothea, Butzkueven, Helmut, Capra, Ruggero, Carroll, William M, Cavalla, Paola, Celius, Elisabeth G, Cepok, Sabine, Chiavacci, Rosetta, Clerget-Darpoux, Françoise, Clysters, Katleen, Comi, Giancarlo, Cossburn, Mark, Cournu-Rebeix, Isabelle, Cox, Mathew B, Cozen, Wendy, Cree, Bruce A C, Cross, Anne H, Cusi, Daniele, Daly, Mark J, Davis, Emma, de Bakker, Paul I W, Debouverie, Marc, D'hooghe, Marie Beatrice, Dixon, Katherine, Dobosi, Rita, Dubois, Bénédicte, Ellinghaus, David, Elovaara, Irina, Esposito, Federica

    Published in Nature (London) (11-08-2011)
    “…The genetics of multiple sclerosis Multiple sclerosis is a disease of the central nervous system that involves interplay between inflammation and…”
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    Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility by Brown, Matthew A, Donnelly, Peter, Evans, David M, Spencer, Chris C A, Pointon, Jennifer J, Su, Zhan, Harvey, David, Kochan, Grazyna, Opperman, Udo, Dilthey, Alexander, Pirinen, Matti, Stone, Millicent A, Appleton, Louise, Moutsianis, Loukas, Leslie, Stephen, Wordsworth, Tom, Kenna, Tony J, Karaderi, Tugce, Thomas, Gethin P, Ward, Michael M, Weisman, Michael H, Farrar, Claire, Bradbury, Linda A, Danoy, Patrick, Inman, Robert D, Maksymowych, Walter, Gladman, Dafna, Rahman, Proton, Morgan, Ann, Marzo-Ortega, Helena, Bowness, Paul, Gaffney, Karl, Gaston, J S Hill, Smith, Malcolm, Bruges-Armas, Jacome, Couto, Ana-Rita, Sorrentino, Rosa, Paladini, Fabiana, Ferreira, Manuel A, Xu, Huji, Liu, Yu, Jiang, Lei, Lopez-Larrea, Carlos, Díaz-Peña, Roberto, López-Vázquez, Antonio, Zayats, Tetyana, Band, Gavin, Bellenguez, Céline, Blackburn, Hannah, Blackwell, Jenefer M, Bramon, Elvira, Bumpstead, Suzannah J, Casas, Juan P, Corvin, Aiden, Craddock, Nicholas, Deloukas, Panos, Dronov, Serge, Duncanson, Audrey, Edkins, Sarah, Freeman, Colin, Gillman, Matthew, Gray, Emma, Gwilliam, Rhian, Hammond, Naomi, Hunt, Sarah E, Jankowski, Janusz, Jayakumar, Alagurevathi, Langford, Cordelia, Liddle, Jennifer, Markus, Hugh S, Mathew, Christopher G, McCann, Owen T, McCarthy, Mark I, Palmer, Colin N A, Peltonen, Leena, Plomin, Robert, Potter, Simon C, Rautanen, Anna, Ravindrarajah, Radhi, Ricketts, Michelle, Samani, Nilesh, Sawcer, Stephen J, Strange, Amy, Trembath, Richard C, Viswanathan, Ananth C, Waller, Matthew, Weston, Paul, Whittaker, Pamela, Widaa, Sara, Wood, Nicholas W, McVean, Gilean, Reveille, John D, Wordsworth, B Paul

    Published in Nature genetics (01-08-2011)
    “…Matthew Brown, Peter Donnelly and colleagues report results of a genome-wide association meta-analysis and follow-up study of ankylosing spondylitis. They…”
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    Multiple common variants for celiac disease influencing immune gene expression by Dubois, Patrick C A, Trynka, Gosia, Franke, Lude, Hunt, Karen A, Romanos, Jihane, Curtotti, Alessandra, Zhernakova, Alexandra, Heap, Graham A R, Ádány, Róza, Aromaa, Arpo, Bardella, Maria Teresa, van den Berg, Leonard H, Bockett, Nicholas A, de la Concha, Emilio G, Dema, Bárbara, Fehrmann, Rudolf S N, Fernández-Arquero, Miguel, Fiatal, Szilvia, Grandone, Elvira, Green, Peter M, Groen, Harry J M, Gwilliam, Rhian, Houwen, Roderick H J, Hunt, Sarah E, Kaukinen, Katri, Kelleher, Dermot, Korponay-Szabo, Ilma, Kurppa, Kalle, MacMathuna, Padraic, Mäki, Markku, Mazzilli, Maria Cristina, McCann, Owen T, Mearin, M Luisa, Mein, Charles A, Mirza, Muddassar M, Mistry, Vanisha, Mora, Barbara, Morley, Katherine I, Mulder, Chris J, Murray, Joseph A, Núñez, Concepción, Oosterom, Elvira, Ophoff, Roel A, Polanco, Isabel, Peltonen, Leena, Platteel, Mathieu, Rybak, Anna, Salomaa, Veikko, Schweizer, Joachim J, Sperandeo, Maria Pia, Tack, Greetje J, Turner, Graham, Veldink, Jan H, Verbeek, Wieke H M, Weersma, Rinse K, Wolters, Victorien M, Urcelay, Elena, Cukrowska, Bozena, Greco, Luigi, Neuhausen, Susan L, McManus, Ross, Barisani, Donatella, Deloukas, Panos, Barrett, Jeffrey C, Saavalainen, Paivi, Wijmenga, Cisca, van Heel, David A

    Published in Nature genetics (01-04-2010)
    “…David van Heel and colleagues report results of a large genome-wide association study of celiac disease. Most of the associated loci contain genes with immune…”
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    Variants in MTNR1B influence fasting glucose levels by Ahmadi, Kourosh, Mooser, Vincent, Wichmann, H-Erich, Sandhu, Manjinder, Saramies, Jouko, Palmer, Colin N A, Isomaa, Bo, Peltonen, Leena, Schlessinger, David, Thorsteinsdottir, Unnur, Hottenga, Jouke-Jan, Jarvelin, Marjo Riitta, McCann, Owen T, Dupuis, Josée, Manning, Alisa K, Cervino, Alessandra, Zeggini, Eleftheria, Boomsma, Dorret I, Soranzo, Nicole, Sijbrands, Eric, Crisponi, Laura, Willemsen, Gonneke, Van Duijn, Cornelia, Stefansson, Kari, Scuteri, Angelo, Watanabe, Richard M, Potter, Simon C, Groop, Leif C, Zhao, Jing Hua, Deloukas, Panos, Freimer, Nelson, Beckmann, Jacques S, Boehnke, Michael, Smit, Jan H, Kong, Augustine, Fox, Caroline S, Bergman, Richard N, Chen, Wei-Min, Cupples, L Adrienne, Florez, Jose C, Erdos, Michael R, Hunt, Sarah, Song, Kijoung, Bochud, Murielle, Kuusisto, Johanna, Dehghan, Abbas, Lindblad, Ulf, Altshuler, David, Sharp, Stephen, Yuan, Xin, Tuomi, Tiinamaija, Vollenweider, Peter, Penninx, Brenda WJH, Aulchenko, Yurii, Saxena, Richa, Voight, Benjamin F, McCarthy, Mark I, Lim, Noha, Lakatta, Edward, Mohlke, Karen L, Uitterlinden, André G, Illig, Thomas, Elliott, Paul, Naitza, Silvia, Randall, Joshua, Krestyaninova, Maria, Morris, Andrew D, Lindgren, Cecilia M, Collins, Francis S, Abecasis, Gonçalo R, Buchanan, Thomas A, Scott, Laura J, Gateva, Vesela, Sanna, Serena, Johnson, Toby, Doney, Alex S F, Spector, Tim D, Waeber, Gerard, Uda, Manuela, Orrù, Marco, Laakso, Markku, Barroso, Inês, Rathmann, Wolfgang, de Geus, Eco J C, Bonnycastle, Lori L, Thorleifsson, Gudmar, Stringham, Heather M, Waterworth, Dawn, Meigs, James B, Wheeler, Eleanor, Witteman, Jacqueline C M, Loos, Ruth J F, Kaakinen, Marika, Lyssenko, Valeriya, Wareham, Nicholas J, Prokopenko, Inga, Cao, Antonio, Scheet, Paul, Hughes, Thomas E, Langenberg, Claudia

    Published in Nature genetics (01-01-2009)
    “…To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide…”
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    Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region by Barrett, Jeffrey C, Lee, James C, Lees, Charles W, Prescott, Natalie J, Anderson, Carl A, Phillips, Anne, Wesley, Emma, Parnell, Kirstie, Zhang, Hu, Drummond, Hazel, Nimmo, Elaine R, Massey, Dunecan, Blaszczyk, Kasia, Elliott, Timothy, Cotterill, Lynn, Dallal, Helen, Lobo, Alan J, Mowat, Craig, Sanderson, Jeremy D, Jewell, Derek P, Newman, William G, Edwards, Cathryn, Ahmad, Tariq, Mansfield, John C, Satsangi, Jack, Parkes, Miles, Mathew, Christopher G, Donnelly, Peter, Peltonen, Leena, Blackwell, Jenefer M, Bramon, Elvira, Brown, Matthew A, Casas, Juan P, Corvin, Aiden, Craddock, Nicholas, Deloukas, Panos, Duncanson, Audrey, Jankowski, Janusz, Markus, Hugh S, McCarthy, Mark I, Palmer, Colin N A, Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J, Samani, Nilesh, Trembath, Richard C, Viswanathan, Anath C, Wood, Nicholas, Spencer, Chris C A, Bellenguez, Céline, Davison, Daniel, Freeman, Colin, Strange, Amy, Langford, Cordelia, Hunt, Sarah E, Edkins, Sarah, Gwilliam, Rhian, Blackburn, Hannah, Bumpstead, Suzannah J, Dronov, Serge, Gillman, Matthew, Gray, Emma, Hammond, Naomi, Jayakumar, Alagurevathi, McCann, Owen T, Liddle, Jennifer, Perez, Marc L, Potter, Simon C, Ravindrarajah, Radhi, Ricketts, Michelle, Waller, Matthew, Weston, Paul, Widaa, Sara, Whittaker, Pamela, Attwood, Antony P, Stephens, Jonathan, Sambrook, Jennifer, Ouwehand, Willem H, McArdle, Wendy L, Ring, Susan M, Strachan, David P

    Published in Nature genetics (01-12-2009)
    “…Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we…”
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    GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level by Schröder, Julia, Chegwidden, Laura, Maj, Carlo, Gehlen, Jan, Speller, Jan, Böhmer, Anne C, Borisov, Oleg, Hess, Timo, Kreuser, Nicole, Venerito, Marino, Alakus, Hakan, May, Andrea, Gerges, Christian, Schmidt, Thomas, Thieme, Rene, Heider, Dominik, Hillmer, Axel M, Reingruber, Julian, Lyros, Orestis, Dietrich, Arne, Hoffmeister, Albrecht, Mehdorn, Matthias, Lordick, Florian, Stocker, Gertraud, Hohaus, Michael, Reim, Daniel, Kandler, Jennis, Müller, Michaela, Ebigbo, Alanna, Fuchs, Claudia, Bruns, Christiane J, Hölscher, Arnulf H, Lang, Hauke, Grimminger, Peter P, Dakkak, Dani, Vashist, Yogesh, May, Sandra, Görg, Siegfried, Franke, Andre, Ellinghaus, David, Galavotti, Sara, Veits, Lothar, Weismüller, Josef, Dommermuth, Jens, Benner, Udo, Rösch, Thomas, Messmann, Helmut, Schumacher, Brigitte, Neuhaus, Horst, Schmidt, Carsten, Wissinowski, Thaddäus T, Nöthen, Markus M, Dong, Jing, Ong, Jue-Sheng, Buas, Matthew F, Thrift, Aaron P, Vaughan, Thomas L, Tomlinson, Ian, Whiteman, David C, Fitzgerald, Rebecca Claire, Jankowski, Janusz, Vieth, Michael, Mayr, Andreas, Gharahkhani, Puya, MacGregor, Stuart, Gockel, Ines, Palles, Claire, Schumacher, Johannes

    Published in Gut (01-04-2023)
    “…Oesophageal cancer (EC) is the sixth leading cause of cancer-related deaths. Oesophageal adenocarcinoma (EA), with Barrett's oesophagus (BE) as a precursor…”
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    MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls by Cosgrove, D, Harold, D, Mothersill, O, Anney, R, Hill, M J, Bray, N J, Blokland, G, Petryshen, T, Richards, A, Mantripragada, K, Owen, M, O'Donovan, M C, Gill, M, Corvin, A, Morris, D W, Donohoe, G

    Published in Translational psychiatry (24-01-2017)
    “…Variants at microRNA-137 (MIR137) , one of the most strongly associated schizophrenia risk loci identified to date, have been associated with poorer cognitive…”
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    The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis by Robinson, P C, Leo, P J, Pointon, J J, Harris, J, Cremin, K, Bradbury, L A, Stebbings, S, Harrison, A A, Evans, D M, Duncan, E L, Wordsworth, B P, Brown, M A

    Published in Genes and immunity (01-01-2016)
    “…Acute anterior uveitis (AAU) involves inflammation of the iris and ciliary body of the eye. It occurs both in isolation and as a complication of ankylosing…”
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    Polygenic risk of ischemic stroke is associated with cognitive ability by Harris, Sarah E, Malik, Rainer, Marioni, Riccardo, Campbell, Archie, Seshadri, Sudha, Worrall, Bradford B, Sudlow, Cathie L.M, Hayward, Caroline, Bastin, Mark E, Starr, John M, Porteous, David J, Wardlaw, Joanna M, Deary, Ian J

    Published in Neurology (16-02-2016)
    “…OBJECTIVES:We investigated the correlation between polygenic risk of ischemic stroke (and its subtypes) and cognitive ability in 3 relatively healthy Scottish…”
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    Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases by Iglesias, Adriana I., Mishra, Aniket, Vitart, Veronique, Bykhovskaya, Yelena, Höhn, René, Springelkamp, Henriët, Cuellar-Partida, Gabriel, Gharahkhani, Puya, Bailey, Jessica N. Cooke, Willoughby, Colin E., Li, Xiaohui, Yazar, Seyhan, Nag, Abhishek, Khawaja, Anthony P., Polašek, Ozren, Siscovick, David, Mitchell, Paul, Tham, Yih Chung, Haines, Jonathan L., Kearns, Lisa S., Hayward, Caroline, Shi, Yuan, van Leeuwen, Elisabeth M., Taylor, Kent D., Bonnemaijer, Pieter, Rotter, Jerome I., Martin, Nicholas G., Zeller, Tanja, Mills, Richard A., Souzeau, Emmanuelle, Staffieri, Sandra E., Jonas, Jost B., Schmidtmann, Irene, Boutin, Thibaud, Kang, Jae H., Lucas, Sionne E. M., Wong, Tien Yin, Beutel, Manfred E., Wilson, James F., Uitterlinden, André G., Vithana, Eranga N., Foster, Paul J., Hysi, Pirro G., Hewitt, Alex W., Khor, Chiea Chuen, Pasquale, Louis R., Montgomery, Grant W., Klaver, Caroline C. W., Aung, Tin, Pfeiffer, Norbert, Mackey, David A., Hammond, Christopher J., Cheng, Ching-Yu, Craig, Jamie E., Rabinowitz, Yaron S., Wiggs, Janey L., Burdon, Kathryn P., van Duijn, Cornelia M., MacGregor, Stuart

    Published in Nature communications (08-01-2019)
    “…Emmanuelle Souzeau, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this Article…”
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