Search Results - "McCann, David J"

A Novel, Nonbinary Evaluation of Success and Failure Reveals Bupropion Efficacy Versus Methamphetamine Dependence: Reanalysis of a Multisite Trial by McCann, David J., Li, Shou-Hua

“…SUMMARY A multisite, double‐blind, placebo‐controlled trial of bupropion for methamphetamine dependence was reanalyzed using a novel, nonbinary method of…”
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Trends in Opioid Analgesic Abuse and Mortality in the United States by McCann, David J, Skolnick, Phil, Bolash, Robert B, Dart, Richard C, Severtson, S. Geoff, Bucher-Bartelson, Becki

“…To the Editor: Dart et al. (Jan. 15 issue) 1 conclude that the United States may be making progress in controlling the abuse of opioid analgesics. However,…”
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Results of a randomized, double-blind, placebo-controlled trial of lorcaserin in cocaine use disorder by McCann, David J., Chen, Hegang H., Devine, Eric G., Gyaw, Shwe, Ramey, Tatiana

“…Cocaine use disorder (CUD) is a major public health problem for which there is no approved pharmacotherapy. The primary purpose of this study was to evaluate…”
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Mitigating the Effects of Nonadherence in Clinical Trials by Shiovitz, Thomas M., Bain, Earle E., McCann, David J., Skolnick, Phil, Laughren, Thomas, Hanina, Adam, Burch, Daniel

“…Accounting for subject nonadherence and eliminating inappropriate subjects in clinical trials are critical elements of a successful study. Nonadherence can…”
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Comparison of the Pharmacokinetic Properties of Naloxone Following the Use of FDA‐Approved Intranasal and Intramuscular Devices Versus a Common Improvised Nasal Naloxone Device by Krieter, Philip A., Chiang, C. Nora, Gyaw, Shwe, McCann, David J.

“…For more than a decade, first responders and the general public have been able to treat suspected opioid overdoses using an improvised nasal naloxone device…”
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Deception by Research Participants by Resnik, David B, McCann, David J

“…Study participants who fabricate, falsify, or fail to disclose important information can undermine the integrity of clinical trials, with negative consequences…”
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Medication Nonadherence, "Professional Subjects," and Apparent Placebo Responders: Overlapping Challenges for Medications Development by McCann, David J, Petry, Nancy M, Bresell, Anders, Isacsson, Eva, Wilson, Ellis, Alexander, Robert C

“…Nonadherence is a major problem in clinical trials of new medications. To evaluate the extent of nonadherence, this study evaluated pharmacokinetic sampling…”
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Placebo-controlled evaluation of a bioengineered, cocaine-metabolizing fusion protein, TV-1380 (AlbuBChE), in the treatment of cocaine dependence by Gilgun-Sherki, Yossi, Eliaz, Rom E, McCann, David J, Loupe, Pippa S, Eyal, Eli, Blatt, Kathleen, Cohen-Barak, Orit, Hallak, Hussein, Chiang, Nora, Gyaw, Shwe

“…Highlights • A placebo-controlled phase 2 study of TV-1380 in cocaine dependence is described. • TV-1380 is a recombinant protein that metabolizes and…”
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Trends in opioid analgesic abuse and mortality in the United States by McCann, David J, Skolnick, Phil

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Measures of outcome for stimulant trials: ACTTION recommendations and research agenda by Kiluk, Brian D, Carroll, Kathleen M, Duhig, Amy, Falk, Daniel E, Kampman, Kyle, Lai, Shengan, Litten, Raye Z, McCann, David J, Montoya, Ivan D, Preston, Kenzie L, Skolnick, Phil, Weisner, Constance, Woody, George, Chandler, Redonna, Detke, Michael J, Dunn, Kelly, Dworkin, Robert H, Fertig, Joanne, Gewandter, Jennifer, Moeller, F. Gerard, Ramey, Tatiana, Ryan, Megan, Silverman, Kenneth, Strain, Eric C

“…Highlights • Meaningful outcome measures, other than sustained abstinence, would be beneficial. • There are multiple challenges unique to measuring stimulant…”
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Linear-rank testing of a non-binary, responder-analysis, efficacy score to evaluate pharmacotherapies for substance use disorders by Holmes, Tyson H, Li, Shou-Hua, McCann, David J

“…The design of pharmacological trials for management of substance use disorders is shifting toward outcomes of successful individual-level behavior (abstinence…”
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Outcome Measures in Medication Trials for Substance Use Disorders by McCann, David J., Ramey, Tatiana, Skolnick, Phil

“…Opinion statement There are multiple therapeutic options to treat tobacco (e.g., nicotine replacement therapies, varenicline) and alcohol (e.g., naltrexone,…”
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Comparison of the Effects of Methamphetamine, Bupropion, and Methylphenidate on the Self-Administration of Methamphetamine by Rhesus Monkeys by Schindler, Charles W, Gilman, Joanne P, Panlilio, Leigh V, McCann, David J, Goldberg, Steven R

“…The effectiveness of methadone as a treatment for opioid abuse and nicotine preparations as treatments for tobacco smoking has led to an interest in developing…”
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Summary of NIDA Medications Workshop: New Opportunities for Chemists and Pharmacologists by Acri, Jane B, Chiang, C Nora, McCann, David J, Shih, Ming L, Vocci, Frank J

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Rash and fever by McCann, David J., Nadel, Eric S., Brown, David F.M.

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Sigma-1 and sigma-2 sites in rat brain: comparison of regional, ontogenetic, and subcellular patterns by McCann, D J, Weissman, A D, Su, T P

“…Radioligand binding assay conditions were established for the selective labeling of sigma-1 and sigma-2 sites in membrane homogenates of rat brain. Selective…”
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Sixth cranial nerve palsy by Shewakramani, Sanjay, McCann, David J., Thomas, Stephen H., Nadel, Eric S., Brown, David F.M.

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Linear-Rank Testing of a Non-Binary, Responder-Analysis, Efficacy Score for Screening Pharmacotherapies for Substance Use Disorders by Holmes, Tyson H, Li, Shou-Hua, McCann, David J

“…Design of pharmacological trials for management of substance use disorders is shifting toward outcomes of successful individual-level behavior (abstinence or…”
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Drugs of abuse: management of intoxication and antidotes by Montoya, Ivan D, McCann, David J

“…Illicit drug intoxications are an increasing public health problem for which, in most cases, no antidotes are clinically available. The diagnosis and treatment…”
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Use of the radial maze in studies of phencyclidine and other drugs of abuse by McCann, D J, Rabin, R A, Winter, J C

“…Effects of drugs known to disrupt performance in an 8-arm radial maze are reported in terms of changes caused in the pattern of arm entry. Phencyclidine (PCP)…”
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