Search Results - "McCamish, M."

The Macrophage ‘Do not eat me’ signal, CD47, is a clinically validated cancer immunotherapy target by Takimoto, C.H., Chao, M.P., Gibbs, C., McCamish, M.A., Liu, J., Chen, J.Y., Majeti, R., Weissman, I.L.

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The Continuum of Comparability Extends to Biosimilarity: How Much Is Enough and What Clinical Data Are Necessary? by McCamish, M, Woollett, G

“…Experts debate the clinical evidence standards needed to approve major manufacturing changes for biologics, biosimilars, and interchangeable biosimilars. As…”
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Molecular “Sameness” Is the Key Guiding Principle for Extrapolation to Multiple Indications by McCamish, M, Woollett, GR

“…Much has been made of biosimilars as a new regulatory concept, yet it is clear that misunderstandings are widespread, including the scientific justification…”
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Toward interchangeable biologics by McCamish, M, Pakulski, J, Sattler, C, Woollett, G

“…A biosimilar is designed to match the reference product – to be as close to the reference as the reference is to itself considering batch‐to‐batch variability…”
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Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency by Farooqi, I. Sadaf, Jebb, Susan A, Langmack, Gill, Lawrence, Elizabeth, Cheetham, Christopher H, Prentice, Andrew M, Hughes, Ieuan A, McCamish, Mark A, O'Rahilly, Stephen

“…Severely obese ( ob/ob ) mice are deficient in the adipocyte-derived hormone leptin, which acts on the hypothalamus to control appetite and energy expenditure…”
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Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma by Houdijk, Alexander PJ, Rijnsburger, Emmy R, Jansen, Jaap, Wesdorp, Robert IC, Weiss, Jeffery K, McCamish, Mark A, Teerlink, Tom, Meuwissen, Stephan GM, Haarman, Henk J Th M, Thijs, Lambertus G, van Leeuwen, Paul AM

“…Infections are an important cause of morbidity and mortality in patients with multiple trauma. Studies in both animals and human beings have suggested that…”
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Effect of three treatment schedules of recombinant methionyl human leptin on body weight in obese adults: a randomized, placebo-controlled trial by Zelissen, P. M. J., Stenlof, K., Lean, M. E. J., Fogteloo, J., Keulen, E. T. P., Wilding, J., Finer, N., Rössner, S., Lawrence, E., Fletcher, C., McCamish, M.

“…Aim:  The aim of this study was to evaluate the effect on body weight and safety of subcutaneously administered recombinant leptin in obese adults and to…”
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Predicting early nonelective hospital readmission in nutritionally compromised older adults by Friedmann, JM, Jensen, GL, Smiciklas-Wright, H, McCamish, MA

“…This study determined predictors of early nonelective hospital readmission in 92 (49 women and 43 men) nutritionally compromised Medicare patients. Subjects…”
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The State of the Art in the Development of Biosimilars by McCamish, Mark, Woollett, Gillian

“…The development of biologic therapeutics using advanced technology to copy and improve on nature's design of complex peptides, proteins, and glycoproteins has…”
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Worldwide experience with biosimilar development by McCamish, Mark, Woollett, Gillian

“…Limited access for high-quality biologics due to cost of treatment constitutes an unmet medical need in the United States (US) and other regions of the world…”
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Intestinal transit and absorption of soy protein in dogs depend on load and degree of protein hydrolysis by Zhao, X T, McCamish, M A, Miller, R H, Wang, L, Lin, H C

“…Soy protein, in both intact and hydrolyzed forms, is widely used as the nitrogen source in infant and adult formulas. This protein is also consumed in vast…”
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Long-term effects of early nutritional support with new enterotropic peptide-based formula vs. standard enteral formula in HIV-infected patients: randomized prospective trial by Chlebowski, R T, Beall, G, Grosvenor, M, Lillington, L, Weintraub, N, Ambler, C, Richards, E W, Abbruzzese, B C, McCamish, M A, Cope, F O

“…Despite association with adverse clinical outcome, human immunodeficiency virus (HIV)-associated malnutrition has been relatively refractory to conventional…”
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Malnutrition and nutrition support interventions: cost, benefits, and outcomes by McCamish, M A

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Safe sex information: getting it right by McCamish, M

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Critical pathways for improved outcome using nutrition support by McCamish, M A

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Amino Acid Losses During Hemodialysis: Effects of High-Solute Flux and Parenteral Nutrition in Acute Renal Failure by Hynote, Eleanor D., McCamish, Mark A., Depner, Thomas A., Davis, Paul A.

“…Background: During standard hemodialysis, amino acid losses are substantial, amounting to 6 to 9 g per treatment. When these nutritional supplements are…”
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Protein absorption depends on load-dependent inhibition of intestinal transit in dogs by Zhao, XT, Miller, RH, McCamish, MA, Wang, L, Lin, HC

“…Ileal perfusion of protein slows intestinal transit. Because optimal absorption of nutrients requires adequate time in contact with the mucosa, slowed…”
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Malnutrition and Clinical Outcomes: The Case for Medical Nutrition Therapy by GALLAGHER ALLRED, CHARLETTE R., COBLE VOSS, ANNE, FINN, SUSAN C., McCAMISH, MARK A.

“…Malnutrition is not a new or a rare problem. In studies involving more than 1,327 hospitalized adult patients, 40% to 55% were found to be either malnourished…”
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Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial by Heymsfield, Steven B, Greenberg, Andrew S, Fujioka, Ken, Dixon, Russell M, Kushner, Robert, Hunt, Thomas, Lubina, John A, Patane, Janet, Self, Barbara, Hunt, Pam, McCamish, Mark

“…CONTEXT The protein hormone leptin is important to the homeostatic regulation of body weight. Treatment with exogenous leptin may affect weight loss. OBJECTIVE…”
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Nutritional intervention in the course of HIV disease by Chlebowski, R T, Beall, G, Lillington, L, Richards, E W, Abbruzzese, B C, McCamish, M A, Cope, F O

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