Search Results - "McCabe Dunn, Jamie M."

Total Synthesis of Darobactin A by Nesic, Marko, Ryffel, David B., Maturano, Jonathan, Shevlin, Michael, Pollack, Scott R., Gauthier, Donald R., Trigo-Mouriño, Pablo, Zhang, Li-Kang, Schultz, Danielle M., McCabe Dunn, Jamie M., Campeau, Louis-Charles, Patel, Niki R., Petrone, David A., Sarlah, David

“…The collaborative total synthesis of darobactin A, a recently isolated antibiotic that selectively targets Gram-negative bacteria, has been accomplished in a…”
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Mechanistic Understanding of a Robust and Scalable Synthesis of Per(6-deoxy-6-halo)cyclodextrins, Versatile Intermediates for Cyclodextrin Modification by Zultanski, Susan L, Kuhl, Nadine, Zhong, Wendy, Cohen, Ryan D, Reibarkh, Mikhail, Jurica, Jon, Kim, Jungchul, Weisel, Lauren, Ekkati, Anil R, Klapars, Artis, Gauthier, Donald R, McCabe Dunn, Jamie M

“…Cyclodextrin (CD) perfunctionalization reactions are challenging to study because they proceed through a number of regioisomeric intermediates, thus warranting…”
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Development of a Palladium-Catalyzed α‑Arylation of Cyclopropyl Nitriles by McCabe Dunn, Jamie M., Kuethe, Jeffrey T., Orr, Robert K., Tudge, Matthew, Campeau, Louis-Charles

“…1,1-Disubstituted aryl cyclopropyl nitriles are useful moieties in biologically active compounds and provide access to a range of cyclopropyl derivatives…”
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The protecting-group free selective 3'-functionalization of nucleosides by McCabe Dunn, Jamie M, Reibarkh, Mikhail, Sherer, Edward C, Orr, Robert K, Ruck, Rebecca T, Simmons, Bryon, Bellomo, Ana

“…The direct and chemoselective 3'-phosphoramidation, phosphorylation and acylation of nucleosides are described. Upon the discovery of a novel…”
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The Safe Use of Sodium Hydride on Scale: The Process Development of a Chloropyrimidine Displacement by McCabe Dunn, Jamie M., Duran-Capece, Alicia, Meehan, Brendan, Ulis, James, Iwama, Tetsuo, Gloor, Guy, Wong, George, Bekos, Evan

“…Sodium hydride was found to be the best base for a displacement reaction on a chloropyrimidine. Due to the insolubility of sodium hydride in all solvents and…”
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Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19 by Deprez, Nicholas R., Hughes, Jonathan M. E., Badir, Shorouk O., Popov, Stasik, Andreani, Teresa, Bade, Rachel S., Hartmanshenn, Clara, Kwok, Thomas Tai-min, Gauthier, Donald R., Salehi Marzijarani, Nastaran, Sakhaei, Zeinab, Drout, Riki, Castro, Steve, Schenk, David J., Wolstenholme, Charles, Padivitage, Nilusha, Welch, Cody, Kowalski, Jason R., Kassim, Brittany, Liu, Yong, Cohen, Ryan D., Confer, Alex M., Dal Poggetto, Guilherme, Brunskill, Andrew P. J., Peng, Feng, Qi, Ji, Xu, Jing, Lin, Mingxiang, McCabe Dunn, Jamie M.

“…We describe the rapid end-game process development for the first good manufacturing process (GMP) delivery of the 3C-like protease inhibitor MK-7845 (1), an…”
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The protecting-group free selective 3′-functionalization of nucleosidesElectronic supplementary information (ESI) available. CCDC 1525736-1525737. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc05081f by McCabe Dunn, Jamie M, Reibarkh, Mikhail, Sherer, Edward C, Orr, Robert K, Ruck, Rebecca T, Simmons, Bryon, Bellomo, Ana

“…The direct and chemoselective 3′-phosphoramidation, phosphorylation and acylation of nucleosides are described. Upon the discovery of a novel…”
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The protecting-group free selective 3′-functionalization of nucleosides† †Electronic supplementary information (ESI) available. CCDC 1525736–1525737. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc05081f Click here for additional data file. Click here for additional data file by McCabe Dunn, Jamie M., Reibarkh, Mikhail, Sherer, Edward C., Orr, Robert K., Ruck, Rebecca T., Simmons, Bryon, Bellomo, Ana

“…The direct and chemoselective 3′-phosphoramidation, phosphorylation and acylation of nucleosides are described. The direct and chemoselective…”
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