Search Results - "McCOY, COLIN P."
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Hydrogel-Forming Microneedle Arrays Allow Detection of Drugs and Glucose In Vivo: Potential for Use in Diagnosis and Therapeutic Drug Monitoring
Published in PloS one (30-12-2015)“…We describe, for the first time the use of hydrogel-forming microneedle (MN) arrays for minimally-invasive extraction and quantification of drug substances and…”
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Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Feasibility Studies and Physicochemical Characterization
Published in Molecular pharmaceutics (06-09-2016)“…Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new…”
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3
Rapid One‐Pot Preparation of Large Freestanding Nanoparticle‐Polymer Films
Published in Small (Weinheim an der Bergstrasse, Germany) (01-01-2017)“…2D arrays of metal nanoparticles formed at liquid–liquid interfaces have been fixed in situ to a thin polymer support to create freestanding large (cm2)…”
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Microwave-Induced In Situ Amorphization: A New Strategy for Tackling the Stability Issue of Amorphous Solid Dispersions
Published in Pharmaceutics (11-07-2020)“…The thermodynamically unstable nature of amorphous drugs has led to a persistent stability issue of amorphous solid dispersions (ASDs). Lately,…”
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5
Metal-Directed Synthesis of Enantiomerially Pure Dimetallic Lanthanide Luminescent Triple-Stranded Helicates
Published in Journal of the American Chemical Society (22-07-2009)“…The synthesis and photophysical evaluation of two enatiomerially pure dimetallic lanthanide luminescent triple-stranded helicates is described. The two…”
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Selective Imaging of Damaged Bone Structure (Microcracks) Using a Targeting Supramolecular Eu(III) Complex As a Lanthanide Luminescent Contrast Agent
Published in Journal of the American Chemical Society (09-12-2009)“…The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone…”
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7
Comparing an Integrated Amphiphilic Surfactant to Traditional Hydrophilic Coatings for the Reduction of Catheter-Associated Urethral Microtrauma
Published in ACS omega (21-05-2024)“…Hydrophilic-coated intermittent catheters have improved the experience of intermittent urinary catheterization for patients compared to conventional…”
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8
Carbon Dots in Photodynamic/Photothermal Antimicrobial Therapy
Published in Nanomaterials (Basel, Switzerland) (01-08-2024)“…Antimicrobial resistance (AMR) presents an escalating global challenge as conventional antibiotic treatments become less effective. In response, photodynamic…”
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Photodynamic antimicrobial polymers for infection control
Published in PloS one (24-09-2014)“…Hospital-acquired infections pose both a major risk to patient wellbeing and an economic burden on global healthcare systems, with the problem compounded by…”
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10
Phosphonium Ionic Liquid-Infused Poly(vinyl chloride) Surfaces Possessing Potent Antifouling Properties
Published in ACS omega (14-04-2020)“…Microbial fouling is a costly issue, which impacts a wide range of industries, such as healthcare, food processing, and construction industries, and improved…”
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Hydrogel Antimicrobial Capture Coatings for Endotracheal Tubes: A Pharmaceutical Strategy Designed to Prevent Ventilator-Associated Pneumonia
Published in Molecular pharmaceutics (03-08-2015)“…This paper presents a novel strategy for the prevention of ventilator-associated pneumonia that involves coating poly(vinyl chloride, PVC) endotracheal tubes…”
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Characterization of the physicochemical, antimicrobial, and drug release properties of thermoresponsive hydrogel copolymers designed for medical device applications
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01-05-2008)“…In this study, a series of hydrogels was synthesized by free radical polymerization, namely poly(2‐(hydroxyethyl)methacrylate) (pHEMA),…”
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The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform
Published in International journal of pharmaceutics (30-08-2020)“…[Display omitted] Amorphous solid dispersion (ASD) is a formulation strategy extensively used to enhance the bioavailability of poorly water soluble drugs…”
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Engaging a Battle on Two Fronts: Dual Role of Polyphosphates as Potent Inhibitors of Struvite Nucleation and Crystal Growth
Published in Chemistry of materials (13-10-2020)“…Polyprotic acids often serve as effective regulators of inorganic crystallization in natural, biological, and synthetic systems. These molecules or…”
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Atmospheric pressure microplasma for antibacterial silver nanoparticle/chitosan nanocomposites with tailored properties
Published in Composites science and technology (20-01-2020)“…Room temperature atmospheric pressure microplasma (APM) was deployed for the first time for the in situ synthesis of antibacterial silver nanoparticle/chitosan…”
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The effects of surfactants on the performance of polymer-based microwave-induced in situ amorphization
Published in International journal of pharmaceutics (05-01-2023)“…[Display omitted] Microwave-induced in situ amorphization is a novel technology for preparing amorphous solid dispersions (ASDs) to address the challenges of…”
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Understanding the properties of intermittent catheters to inform future development
Published in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine (01-06-2024)“…Despite the extensive use of intermittent catheters (ICs) in healthcare, various issues persist for long-term IC users, such as pain, discomfort, infection,…”
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Luminescent Lanthanide Cyclen-Based Enzymatic Assay Capable of Diagnosing the Onset of Catheter-Associated Urinary Tract Infections Both in Solution and within Polymeric Hydrogels
Published in Journal of the American Chemical Society (11-01-2017)“…Herein we present a supramolecular (delayed luminescent) Eu(III)-based pH-responsive probe/sensor with the ability to detect the urease-mediated hydrolysis of…”
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19
Use of solid thermolytic salts to facilitate microwave-induced in situ amorphization
Published in International journal of pharmaceutics (15-02-2024)“…[Display omitted] Moisture was frequently used as dielectric heating source in classical microwave-able systems to facilitate microwave-induced in situ…”
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Time‐Resolved Dynamics of Struvite Crystallization: Insights from the Macroscopic to Molecular Scale
Published in Chemistry : a European journal (18-03-2020)“…The crystallization of magnesium ammonium phosphate hexahydrate (struvite) often occurs under conditions of fluid flow, yet the dynamics of struvite growth…”
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