Search Results - "McBurney, Michael W."

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade by Hsu, Joy, Hodgins, Jonathan J, Marathe, Malvika, Nicolai, Chris J, Bourgeois-Daigneault, Marie-Claude, Trevino, Troy N, Azimi, Camillia S, Scheer, Amit K, Randolph, Haley E, Thompson, Thornton W, Zhang, Lily, Iannello, Alexandre, Mathur, Nikhita, Jardine, Karen E, Kirn, Georgia A, Bell, John C, McBurney, Michael W, Raulet, David H, Ardolino, Michele

“…Checkpoint blockade immunotherapy targeting the PD-1/PD-L1 inhibitory axis has produced remarkable results in the treatment of several types of cancer. Whereas…”
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AMP-Activated Protein Kinase―Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol by UM, Jee-Hyun, PARK, Sung-Jun, KANG, Hyeog, SHUTONG YANG, FORETZ, Marc, MCBURNEY, Michael W, KIM, Myung K, VIOLLET, Benoit, CHUNG, Jay H

“…Resveratrol, a natural polyphenolic compound that is found in grapes and red wine, increases metabolic rate, insulin sensitivity, mitochondrial biogenesis, and…”
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SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons by Li, Ying, Xu, Wei, McBurney, Michael W., Longo, Valter D.

“…Sirtuins are known to protect cells and extend life span, but our previous studies indicated that S. cerevisiae Sir2 can also increase stress sensitivity and…”
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SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice by Yao, Hongwei, Chung, Sangwoon, Hwang, Jae-woong, Rajendrasozhan, Saravanan, Sundar, Isaac K, Dean, David A, McBurney, Michael W, Guarente, Leonard, Gu, Wei, Rönty, Mikko, Kinnula, Vuokko L, Rahman, Irfan

“…Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized by chronic inflammation and premature lung aging. Anti-aging sirtuin 1…”
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Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage by Hernández-Jiménez, Macarena, Hurtado, Olivia, Cuartero, María I, Ballesteros, Iván, Moraga, Ana, Pradillo, Jesús M, McBurney, Michael W, Lizasoain, Ignacio, Moro, María A

“…BACKGROUND AND PURPOSE—Sirtuin 1 (SIRT1) is a member of NAD-dependent protein deacetylases implicated in a wide range of cellular functions and has beneficial…”
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Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt by Fulco, Marcella, Cen, Yana, Zhao, Po, Hoffman, Eric P., McBurney, Michael W., Sauve, Anthony A., Sartorelli, Vittorio

“…It is intuitive to speculate that nutrient availability may influence differentiation of mammalian cells. Nonetheless, a comprehensive complement of the…”
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SIRT1-Mediated Deacetylation of CRABPII Regulates Cellular Retinoic Acid Signaling and Modulates Embryonic Stem Cell Differentiation by Tang, Shuang, Huang, Gang, Fan, Wei, Chen, Yue, Ward, James M., Xu, Xiaojiang, Xu, Qing, Kang, Ashley, McBurney, Michael W., Fargo, David C., Hu, Guang, Baumgart-Vogt, Eveline, Zhao, Yingming, Li, Xiaoling

“…Retinoid homeostasis is critical for normal embryonic development. Both the deficiency and excess of these compounds are associated with congenital…”
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role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction by Fusco, Salvatore, Ripoli, Cristian, Podda, Maria Vittoria, Ranieri, Sofia Chiatamone, Leone, Lucia, Toietta, Gabriele, McBurney, Michael W, Schütz, Günther, Riccio, Antonella, Grassi, Claudio, Galeotti, Tommaso, Pani, Giovambattista

“…Calorie restriction delays brain senescence and prevents neurodegeneration, but critical regulators of these beneficial responses other than the NAD+-dependent…”
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Sirtuin 1 in immune regulation and autoimmunity by Kong, Sinyi, McBurney, Michael W, Fang, Deyu

“…The NAD‐dependent histone deacetylase sirtuin (Sirt)1 is implicated in a wide variety of physiological processes, ranging from tumorigenesis to mitochondrial…”
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SirT1 regulates energy metabolism and response to caloric restriction in mice by Boily, Gino, Seifert, Erin L, Bevilacqua, Lisa, He, Xiao Hong, Sabourin, Guillaume, Estey, Carmen, Moffat, Cynthia, Crawford, Sean, Saliba, Sarah, Jardine, Karen, Xuan, Jian, Evans, Meredith, Harper, Mary-Ellen, McBurney, Michael W

“…The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction…”
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The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance by Chuprin, Anna, Avin, Ayelet, Goldfarb, Yael, Herzig, Yonatan, Levi, Ben, Jacob, Adi, Sela, Asaf, Katz, Shir, Grossman, Moran, Guyon, Clotilde, Rathaus, Moran, Cohen, Haim Y, Sagi, Irit, Giraud, Matthieu, McBurney, Michael W, Husebye, Eystein S, Abramson, Jakub

“…Dysfunction of the deacetylase Sirt1 has been associated with certain metabolic diseases. Abramson and colleagues show that Sirt1 has high expression in the…”
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Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization by Cheng, Junrui, Liu, Chun, Hu, Kangquan, Greenberg, Andrew, Wu, Dayong, Ausman, Lynne M., McBurney, Michael W., Wang, Xiang-Dong

“…Sirtuin 1 (SIRT1) has been reported to protect against nonalcoholic fatty liver disease (NAFLD) development. The mechanism of how SIRT1 deacetylase activity…”
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SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism by Yao, Hongwei, Sundar, Isaac K, Ahmad, Tanveer, Lerner, Chad, Gerloff, Janice, Friedman, Alan E, Phipps, Richard P, Sime, Patricia J, McBurney, Michael W, Guarente, Leonard, Rahman, Irfan

“…Oxidative and carbonyl stress is increased in lungs of smokers and patients with chronic obstructive pulmonary disease (COPD), as well as in cigarette smoke…”
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Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD by Hwang, Jae-woong, Chung, Sangwoon, Sundar, Isaac K., Yao, Hongwei, Arunachalam, Gnanapragasam, McBurney, Michael W., Rahman, Irfan

“…Autophagy is a fundamental cellular process that eliminates long-lived proteins and damaged organelles through lysosomal degradation pathway. Cigarette smoke…”
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The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome by Caron, Annabelle Z., He, Xiaohong, Mottawea, Walid, Seifert, Erin L., Jardine, Karen, Dewar‐Darch, Danielle, Cron, Greg O., Harper, Mary‐Ellen, Stintzi, Alain, McBurney, Michael W.

“…Type 2 diabetes, hepatic steatosis, and gut dysbiosis are pathophysiological consequences of obesity. Sirtuin (SIRT)‐1 is a protein deacetylase implicated in…”
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A Local Mechanism Mediates NAD-Dependent Protection of Axon Degeneration by Wanq, Jinq, Zhai, Qiwei, Chen, Ying, Lin, Estelle, Gu, Wei, McBurney, Michael W., He, Zhigang

“…Axon degeneration occurs frequently in neurodegenerative diseases and peripheral neuropathies. Important insight into the mechanisms of axon degeneration arose…”
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SIRT1-mediated acute cardioprotection by Nadtochiy, Sergiy M, Yao, Hongwei, McBurney, Michael W, Gu, Wei, Guarente, Leonard, Rahman, Irfan, Brookes, Paul S

“…Overexpression studies have revealed a role for silent information regulator of transcription 1 (SIRT1) lysine deacetylase in cardioprotection against…”
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SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD by Yao, Hongwei, Hwang, Jae-woong, Sundar, Isaac K, Friedman, Alan E, McBurney, Michael W, Guarente, Leonard, Gu, Wei, Kinnula, Vuokko L, Rahman, Irfan

“…Sirtuin1 (SIRT1), a protein/histone deacetylase, protects against the development of pulmonary emphysema. However, the molecular mechanisms underlying this…”
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Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes by Biason-Lauber, Anna, Böni-Schnetzler, Marianne, Hubbard, Basil P., Bouzakri, Karim, Brunner, Andrea, Cavelti-Weder, Claudia, Keller, Cornelia, Meyer-Böni, Monika, Meier, Daniel T., Brorsson, Caroline, Timper, Katharina, Leibowitz, Gil, Patrignani, Andrea, Bruggmann, Remy, Boily, Gino, Zulewski, Henryk, Geier, Andreas, Cermak, Jennifer M., Elliott, Peter, Ellis, James L., Westphal, Christoph, Knobel, Urs, Eloranta, Jyrki J., Kerr-Conte, Julie, Pattou, François, Konrad, Daniel, Matter, Christian M., Fontana, Adriano, Rogler, Gerhard, Schlapbach, Ralph, Regairaz, Camille, Carballido, José M., Glaser, Benjamin, McBurney, Michael W., Pociot, Flemming, Sinclair, David A., Donath, Marc Y.

“…Type 1 diabetes is caused by autoimmune-mediated β cell destruction leading to insulin deficiency. The histone deacetylase SIRT1 plays an essential role in…”
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Loss of Sirt1 Promotes Prostatic Intraepithelial Neoplasia, Reduces Mitophagy, and Delays Park2 Translocation to Mitochondria by Di Sante, Gabriele, Pestell, Timothy G, Casimiro, Mathew C, Bisetto, Sara, Powell, Michael J, Lisanti, Michael P, Cordon-Cardo, Carlos, Castillo-Martin, Mireia, Bonal, Dennis M, Debattisti, Valentina, Chen, Ke, Wang, Liping, He, Xiaohong, McBurney, Michael W, Pestell, Richard G

“…Prostatic intraepithelial neoplasia is a precursor to prostate cancer. Herein, deletion of the NAD+ -dependent histone deacetylase Sirt1 induced histological…”
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