Search Results - "McBryde, Fiona D."

Correcting an overactive exercise pressor reflex: A new role for purinergic signalling? by McBryde, Fiona D.

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Purinergic receptors in the carotid body as a new drug target for controlling hypertension by Pijacka, Wioletta, Moraes, Davi J A, Ratcliffe, Laura E K, Nightingale, Angus K, Hart, Emma C, da Silva, Melina P, Machado, Benedito H, McBryde, Fiona D, Abdala, Ana P, Ford, Anthony P, Paton, Julian F R

“…A small-molecule antagonist of the P2X3 receptor reduces blood pressure in hypertensive rats via its action on the carotid body, pointing to a new drug target…”
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The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension by McBryde, Fiona D., Abdala, Ana P., Hendy, Emma B., Pijacka, Wioletta, Marvar, Paul, Moraes, Davi J. A., Sobotka, Paul A., Paton, Julian F. R.

“…In the spontaneously hypertensive (SH) rat, hyperoxic inactivation of the carotid body (CB) produces a rapid and pronounced fall in both arterial pressure and…”
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Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat by Abdala, Ana P., McBryde, Fiona D., Marina, Nephtali, Hendy, Emma B., Engelman, Zoar J., Fudim, Marat, Sobotka, Paul A., Gourine, Alexander V., Paton, Julian F. R.

“…Key points Peripheral chemoreflex sensitivity is enhanced in hypertension yet the role of these receptors in the development and maintenance of high blood…”
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Recording of intracranial pressure in conscious rats via telemetry by Guild, Sarah-Jane, McBryde, Fiona D, Malpas, Simon C

“…Although cerebral perfusion pressure (CPP) is known to be fundamental in the control of normal brain function, there have been no previous long-term…”
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The Carotid Body as a Therapeutic Target for the Treatment of Sympathetically Mediated Diseases by Paton, Julian F.R, Sobotka, Paul A, Fudim, Marat, Engleman, Zoar J, Hart, Emma C.J, McBryde, Fiona D, Abdala, Ana P, Marina, Nepthali, Gourine, Alexander V, Lobo, Mel, Patel, Nik, Burchell, Amy, Ratcliffe, Laura, Nightingale, Angus

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Variable role of carotid bodies in cardiovascular responses to exercise, hypoxia and hypercapnia in spontaneously hypertensive rats by Pijacka, Wioletta, Katayama, Pedro L., Salgado, Helio C., Lincevicius, Gisele S., Campos, Ruy R., McBryde, Fiona D., Paton, Julian F.R.

“…Key points Carotid bodies play a critical role in maintaining arterial pressure during hypoxia and this has important implications when considering resection…”
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Translational Examination of Changes in Baroreflex Function After Renal Denervation in Hypertensive Rats and Humans by Hart, Emma C., McBryde, Fiona D., Burchell, Amy E., Ratcliffe, Laura E.K., Stewart, Lesley Q., Baumbach, Andreas, Nightingale, Angus, Paton, Julian F.R.

“…Renal denervation has shown promise in the treatment of resistant hypertension, although the mechanisms underlying the blood pressure (BP) reduction remain…”
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Blockade of Rostral Ventrolateral Medulla Apelin Receptors Does Not Attenuate Arterial Pressure in SHR and L -NAME-Induced Hypertensive Rats by Griffiths, Philip R, Lolait, Stephen J, Pearce, Louise E, McBryde, Fiona D, Paton, Julian F R, O'Carroll, Anne-Marie

“…Dysfunction of the apelinergic system, comprised of the neuropeptide apelin mediating its effects via the G protein-coupled apelin receptor (APJ), may underlie…”
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Quantifying sympathetic nerve activity: problems, pitfalls and the need for standardization by Guild, Sarah‐Jane, Barrett, Carolyn J., McBryde, Fiona D., Van Vliet, Bruce N., Head, Geoffrey A., Burke, Sandra L., Malpas, Simon C.

“…Since the first recording of sympathetic nerve activity (SNA) early last century, numerous methods for presentation of the resulting data have developed. In…”
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Integrative cerebral blood flow regulation in ischemic stroke by Fan, Jui-Lin, Brassard, Patrice, Rickards, Caroline A, Nogueira, Ricardo C, Nasr, Nathalie, McBryde, Fiona D, Fisher, James P, Tzeng, Yu-Chieh

“…Optimizing cerebral perfusion is key to rescuing salvageable ischemic brain tissue. Despite being an important determinant of cerebral perfusion, there are no…”
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Combined Arterial Hypertension and Ischemic Stroke Exaggerate Anesthesia-Related Hypotension and Cerebral Oxygenation Deficits: A Preclinical Study by Zhang, Tracy, Thakkar, Pratik, Emans, Tonja W., Fong, Debra, Thampi, Suma, Felippe, Igor S. A., Barrett, Carolyn J., Billing, Robyn, Campbell, Douglas, McBryde, Fiona D.

“…Intraoperative arterial hypotension (IOH) is a common side effect of general anesthesia (GA), associated with poor outcomes in ischemic stroke. While IOH is…”
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Forgotten Circulation: Reduced Mesenteric Venous Capacitance in Hypertensive Rats Is Improved by Decreasing Sympathetic Activity by Emans, Tonja W, Moraes, Davi J A, Ben-Tal, Alona, Barrett, Carolyn J, Paton, Julian F R, McBryde, Fiona D

“…The mesenteric venous reservoir plays a vital role in mediating blood volume and pressure changes and is richly innervated by sympathetic nerves; however, the…”
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Angiotensin II-based hypertension and the sympathetic nervous system: the role of dose and increased dietary salt in rabbits by McBryde, Fiona D., Guild, Sarah‐Jane, Barrett, Carolyn J., Osborn, John W., Malpas, Simon C.

“…There is accumulating evidence that angiotensin II may exert its hypertensive effect through increasing sympathetic drive. However, this action may be…”
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A method to evaluate dynamic cerebral pressure-flow relationships in the conscious rat by Fong, Debra, Gradon, Kelly, Barrett, Carolyn J., Guild, Sarah-Jane, Tzeng, Yu Chieh, Paton, Julian F. R., McBryde, Fiona D.

“…We present a novel technique to overcome the use of vasoactive agents when studying cerebrovascular dynamics in the conscious rat. Our method of vena cava…”
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High Dietary Salt and Angiotensin II Chronically Increase Renal Sympathetic Nerve Activity: A Direct Telemetric Study by Guild, Sarah-Jane, McBryde, Fiona D, Malpas, Simon C, Barrett, Carolyn J

“…Overactivity of the sympathetic nervous system has long been implicated in the hypertensive response to elevated angiotensin II (Ang II) levels. Although…”
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The inevitability of ATP as a transmitter in the carotid body by Bardsley, Emma N., Pen, Dylan K., McBryde, Fiona D., Ford, Anthony P., Paton, Julian F.R.

“…Atmospheric oxygen concentrations rose markedly at several points in evolutionary history. Each of these increases was followed by an evolutionary leap in…”
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Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats by Pijacka, Wioletta, McBryde, Fiona D., Marvar, Paul J., Lincevicius, Gisele S., Abdala, Ana P. L., Woodward, Lavinia, Li, Dan, Paterson, David J., Paton, Julian F. R.

“…Key points Peripheral chemoreflex sensitization is a feature of renovascular hypertension. Carotid sinus nerve denervation (CSD) has recently been shown to…”
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Role of the Carotid Body in an Ovine Model of Renovascular Hypertension by Chang, Joshua Wen-Han, Tromp, Tycho R., Joles, Jaap A., McBryde, Fiona D., Paton, Julian F.R., Ramchandra, Rohit

“…The carotid body is implicated as an important mediator and potential treatment target for hypertension. The mechanisms driving increased carotid body tonicity…”
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Therapeutic Relevance of Elevated Blood Pressure After Ischemic Stroke in the Hypertensive Rats by Thakkar, Pratik C., McGregor, Ailsa L., Barber, P. Alan, Paton, Julian F.R., Barrett, Carolyn J., McBryde, Fiona D.

“…Over 80% of patients exhibit an acute increase in blood pressure (BP) following stroke. Current clinical guidelines make no distinction in BP management…”
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