Search Results - "McBride, M H"

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics by Irrcher, I., Aleyasin, H., Seifert, E.L., Hewitt, S.J., Chhabra, S., Phillips, M., Lutz, A.K., Rousseaux, M.W.C., Bevilacqua, L., Jahani-Asl, A., Callaghan, S., MacLaurin, J.G., Winklhofer, K.F., Rizzu, P., Rippstein, P., Kim, R.H., Chen, C.X., Fon, E.A., Slack, R.S., Harper, M.E., McBride, H.M., Mak, T.W., Park, D.S.

“…Growing evidence highlights a role for mitochondrial dysfunction and oxidative stress as underlying contributors to Parkinson's disease (PD) pathogenesis. DJ-1…”
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The Rab5 effector EEA1 is a core component of endosome docking by Zerial, Marino, Christoforidis, Savvas, McBride, Heidi M, Burgoyne, Robert D

“…Intracellular membrane docking and fusion requires the interplay between soluble factors and SNAREs. The SNARE hypothesis postulates that pairing between a…”
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Structural and mechanistic basis of Parl activity and regulation by Jeyaraju, D V, McBride, H M, Hill, R B, Pellegrini, L

“…The mitochondrial rhomboid protease Parl governs apoptosis, morphology, metabolism and might be implicated in Parkinson's disease, but the structural basis of…”
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Monoclonal Antibody Therapy of B Cell Lymphoma: Signaling Activity on Tumor Cells Appears More Important Than Recruitment of Effectors by Tutt, Alison L, French, Ruth R, Illidge, Timothy M, Honeychurch, Jamie, McBride, Harry M, Penfold, Christine A, Fearon, Douglas T, Parkhouse, R. Michael E, Klaus, Gerry G. B, Glennie, Martin J

“…Despite the recent success of mAb in the treatment of certain malignancies, there is still considerable uncertainty about the mechanism of action of…”
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Preparation and performance of bispecific F(ab' gamma)2 antibody containing thioether-linked Fab' gamma fragments by Glennie, MJ, McBride, HM, Worth, AT, Stevenson, GT

“…A simple and efficient method is described for the production of pure bispecific F(ab' gamma)2 heterodimers, in which the individual antibody Fab' gamma…”
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A signal-anchor sequence selective for the mitochondrial outer membrane by McBride, H.M. (McGill University, Montreal, Canada), Millar, D.G, Li, J.M, Shore, G.C

“…pOMD29 is a hybrid protein containing the NH2-terminal topogenic sequence of a bitopic, integral protein of the outer mitochondrial membrane in yeast, OMM70,…”
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Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13 by McBride, Heidi M, Rybin, Vladimir, Murphy, Carol, Giner, Angelika, Teasdale, Rohan, Zerial, Marino

“…SNAREs and Rab GTPases cooperate in vesicle transport through a mechanism yet poorly understood. We now demonstrate that the Rab5 effectors EEA1 and…”
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The Importance of Antibody-Specificity in Determining Successful Radioimmunotherapy of B-Cell Lymphoma by Illidge, Timothy M., Cragg, Mark S., McBride, Harry M., French, Ruth R., Glennie, Martin J.

“…We report the radioimmunotherapy of mouse B-cell lymphoma, BCL1, using a panel of anti–B-cell monoclonal antibodies (MoAb) (anti-CD19, anti-CD22, anti-major…”
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Production and characterization of monoclonal antibodies specific for human mast cell tryptase by Walls, A F, Bennett, A R, McBride, H M, Glennie, M J, Holgate, S T, Church, M K

“…Human mast cell tryptase was purified from lung tissue by high salt extraction, ammonium sulphate precipitation, octyl Sepharose and heparin-agarose…”
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A Novel Rab5 GDP/GTP Exchange Factor Complexed to Rabaptin-5 Links Nucleotide Exchange to Effector Recruitment and Function by Horiuchi, Hisanori, Lippé, Roger, McBride, Heidi M., Rubino, Mariantonietta, Woodman, Philip, Stenmark, Harald, Rybin, Vladimir, Wilm, Matthias, Ashman, Keith, Mann, Matthias, Zerial, Marino

“…The small GTPase Rab5 plays an essential role in endocytic traffic. Rab GDP dissociation inhibitor delivers Rab5 to the membrane, where a nucleotide exchange…”
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Bispecific F(ab' gamma)2 antibody for the delivery of saporin in the treatment of lymphoma by Glennie, MJ, Brennand, DM, Bryden, F, McBride, HM, Stirpe, F, Worth, AT, Stevenson, GT

“…This work describes the successful use of bispecific F(ab' gamma)2 antibody (Ab) in combination with a ribosome-inactivating protein (RIP), saporin, for the…”
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Emergence of immunoglobulin variants following treatment of A B cell leukemia with an immunotoxin composed of antiidiotypic antibody and saporin by GLENNIE, M. J, MCBRIDE, H. M, STIRPE, F, THORPE, P. E, WORTH, A. T, STEVENSON, G. T

“…The potency and specificity of immunotoxins consisting of monoclonal antiidiotype conjugated to the ribosome-inactivating protein, saporin, have been evaluated…”
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Analysis of the interaction of antibodies with immunoglobulin idiotypes on neoplastic B lymphocytes: implications for immunotherapy by Elliott, TJ, Glennie, MJ, McBride, HM, Stevenson, GT

“…We have examined the reactions of a panel of nine monoclonal anti-idiotype antibodies with the surface immunoglobulin in situ on guinea pig L2C leukemic…”
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Characterisation of a new murine B cell lymphoma by COBB, L. M, GLENNIE, M. J, MCBRIDE, H. M, BRECKON, G, RICHARDSON, T. C

“…The characterisation of a new murine B cell lymphoma, A31, is described. Histopathological examination of passaged tumour indicates that initial infiltration…”
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The Role of Outer Membrane Proteins in the Survival of Neisseria gonorrhoeae P9 within Guinea-pig Subcutaneous Chambers by McBRIDE, H. M, LAMBDEN, P. R, HECKELS, J. E, WATT, P. J

“…Department of Microbiology, Southampton University Medical School, Southampton General Hospital, Tremona Road, Southampton SO9 4XY, U.K. ABSTRACT Guinea-pig…”
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Development of core competencies in clinical nutrition by Young, EA, Weser, E, McBride, HM, Page, CP, Littlefield, JH

“…A nationwide survey of core competencies of nutrition knowledge and skills that primary care physicians should know and/or be able to do has been completed…”
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mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1 by Morita, Masahiro, Prudent, Julien, Basu, Kaustuv, Goyon, Vanessa, Katsumura, Sakie, Hulea, Laura, Pearl, Dana, Siddiqui, Nadeem, Strack, Stefan, McGuirk, Shawn, St-Pierre, Julie, Larsson, Ola, Topisirovic, Ivan, Vali, Hojatollah, McBride, Heidi M., Bergeron, John J., Sonenberg, Nahum

“…The mechanisms that link environmental and intracellular stimuli to mitochondrial functions, including fission/fusion, ATP production, metabolite biogenesis,…”
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Performance testing of the environmental TLD system for the Three Mile Island Nuclear Station by Toke, L F, Carson, B H, Baker, G G, McBride, M H, Plato, P A, Miklos, J A

“…Panasonic UD-801 thermoluminescent dosimeters ( TLDs ) containing two calcium sulfate phosphors were tested under Performance Specification 3.1 established by…”
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The Human Mitochondrial Import Receptor, hTom20p, Prevents a Cryptic Matrix Targeting Sequence from Gaining Access to the Protein Translocation Machinery by McBride, Heidi M., Goping, Ing Swie, Shore, Gordon C.

“…Yeast Mas70p and NADH cytochrome b5reductase are bitopic integral proteins of the mitochondrial outer membrane and are inserted into the lipidbilayer in an…”
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Monoclonal antibodies raised against the idiotype of the murine B cell lymphoma, BCL1 act primarily with heavy chain determinants by George, A J, McBride, H M, Glennie, M J, Smith, L J, Stevenson, F K

“…Anti-idiotypic antibodies can be used as probes to distinguish neoplastic cells from their normal counterparts. In addition they have been used in the passive…”
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