Search Results - "McBrayer, Mary Kate"

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification by Lee, Ju-Hyun, McBrayer, Mary Kate, Wolfe, Devin M., Haslett, Luke J., Kumar, Asok, Sato, Yutaka, Lie, Pearl P.Y., Mohan, Panaiyur, Coffey, Erin E., Kompella, Uday, Mitchell, Claire H., Lloyd-Evans, Emyr, Nixon, Ralph A.

“…Presenilin 1 (PS1) deletion or Alzheimer’s disease (AD)-linked mutations disrupt lysosomal acidification and proteolysis, which inhibits autophagy. Here, we…”
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Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells by Stalnecker, Clint A., Ulrich, Scott M., Li, Yunxing, Ramachandran, Sekar, McBrayer, Mary Kate, DeBerardinis, Ralph J., Cerione, Richard A., Erickson, Jon W.

“…The mitochondrial enzyme glutaminase C (GAC) catalyzes the hydrolysis of glutamine to glutamate plus ammonia, a key step in the metabolism of glutamine by…”
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Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification by Lee, Ju-Hyun, McBrayer, Mary Kate, Wolfe, Devin M, Haslett, Luke J, Kumar, Asok, Sato, Yutaka, Lie, Pearl P Y, Mohan, Panaiyur, Coffey, Erin E, Kompella, Uday, Mitchell, Claire H, Lloyd-Evans, Emyr, Nixon, Ralph A

“…Presenilin 1 (PS1) deletion or Alzheimer's disease (AD)-linked mutations disrupt lysosomal acidification and proteolysis, which inhibits autophagy. Here, we…”
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β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7 by Lee, Ju-Hyun, Wolfe, Devin M., Darji, Sandipkumar, McBrayer, Mary Kate, Colacurcio, Daniel J., Kumar, Asok, Stavrides, Philip, Mohan, Panaiyur S., Nixon, Ralph A.

“…Lysosomal dysfunction is considered pathogenic in Alzheimer disease (AD). Loss of presenilin-1 (PSEN1) function causing AD impedes acidification via defective…”
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Abstract LB006: PC14586: The first orally bioavailable small molecule reactivator of Y220C mutant p53 in clinical development by Dumble, Melissa, Xu, Lizhong, Dominique, Romyr, Liu, Binbin, Yang, Hong, McBrayer, Mary-Kate, Thomas, Dafydd, Fahr, Bruce, Li, Hongju, Huang, Kuo-Sen, Robell, Kimberly, Mulligan, Chris, Russo, Brandon, Puzio-Kuter, Anna, Davis, Thomas, Vu, Binh

“…Abstract Mutations in the TP53 gene are the most frequent somatic alterations in human cancer; approximately 50% of all human cancers possess mutations in…”
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Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice by Rao, Mala V, McBrayer, Mary Kate, Campbell, Jabbar, Kumar, Asok, Hashim, Audrey, Sershen, Henry, Stavrides, Philip H, Ohno, Masuo, Hutton, Michael, Nixon, Ralph A

“…Tau pathogenicity in Alzheimer's disease and other tauopathies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau…”
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Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160 by Zeigerer, Anja, McBrayer, Mary Kate, McGraw, Timothy E

“…Insulin maintains whole body blood glucose homeostasis, in part, by regulating the amount of the GLUT4 glucose transporter on the cell surface of fat and…”
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Presenilin 1 maintains lysosomal Ca2+ homeostasis by regulating vATPase-mediated lysosome acidification by Lee, Ju-Hyun, McBrayer, Mary Kate, Wolfe, Devin M., Haslett, Luke J., Kumar, Asok, Sato, Yutaka, Lie, Pearl P. Y., Mohan, Panaiyur, Coffey, Erin E., Kompella, Uday, Mitchell, Claire H., Lloyd-Evans, Emyr, Nixon, Ralph A.

“…Presenilin-1 (PS1) deletion or Alzheimer’s Disease (AD)-linked mutations disrupt lysosomal acidification and proteolysis, which inhibits autophagy. Here, we…”
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Spatial and transcriptional regulation of onco-dbl-mediated cellular transformation by McBrayer, Mary Kate

“…Onco-dbl functions as a guanine nucleotide exchange factor (GEF) with the ability to activate the small G-proteins, Cdc42 and Rho. This results in the…”
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A pH dependence study on the unfolding and refolding of apoazurin: Comparison with Zn(II) auzurin by Hansen, John E, Mcbrayer, Mary Kate, Robbins, Michael, Suh, Yong

“…Azurin, a small blue copper protein from the bacterial species Pseudomonas aeruginosa, is mostly a β-sheet protein arranged into a single domain. Previous…”
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A pH dependence study on the unfolding and refolding of apoazurin by Hansen, John E, McBrayer, Mary Kate, Robbins, Michael, Suh, Yong

“…Azurin, a small blue copper protein from the bacterial species Pseudomonas aeruginosa, is mostly a β-sheet protein arranged into a single domain. Previous…”
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A pH dependence study on the unfolding and refolding of apoazurin: comparison with Zn(II) azurin by Hansen, John E, McBrayer, Mary Kate, Robbins, Michael, Suh, Yong

“…Azurin, a small blue copper protein from the bacterial species Pseudomonas aeruginosa, is mostly a beta-sheet protein arranged into a single domain. Previous…”
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