Search Results - "McBean, G J"

Redox‐based therapeutics in neurodegenerative disease by McBean, G J, López, M G, Wallner, F K

“…This review describes recent developments in the search for effective therapeutic agents that target redox homeostasis in neurodegenerative disease. The…”
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Molecular mechanisms of cystine transport by McBean, G J, Flynn, J

“…The transport of L-cystine into cells of the mammalian brain is an essential step in the supply of cysteine for synthesis of the antioxidant glutathione…”
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Comparative potencies of 3,4‐methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5‐HT transport in mammalian cell lines by Montgomery, T, Buon, C, Eibauer, S, Guiry, P J, Keenan, A K, McBean, G J

“…Background and purpose: Illegal ‘ecstasy’ tablets frequently contain 3,4‐methylenedioxymethamphetamine (MDMA)‐like compounds of unknown pharmacological…”
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Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, αaminoadipate by MCBEAN, G. J

“…1. The effect of the gliotoxic analogue of glutamate, alpha aminoadipate, on the high affinity transport of D-[3H]-aspartate into a crude striatal P2…”
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Kinetic and pharmacological analysis of l-[ 35S]cystine transport into rat brain synaptosomes by Flynn, James, McBean, Gethin J

“…The synaptosomal transport of l-[ 35S]cystine occurs by three mechanisms that are distinguishable on the basis of their ionic dependence, kinetics of transport…”
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Chronic haloperidol treatment impairs glutamate transport in the rat striatum by De Souza, Ian E.J, McBean, Gethin J, Meredith, Gloria E

“…High-affinity, Na +-dependent transport of glutamate into neurons and glial cells maintains the extracellular concentration of this neurotransmitter at a…”
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Stimulation of synaptosomal d-[ 3H]aspartate transport by substance P in rat brain by Healy, Joseph, Downes, Andrew, McBean, Gethin J

“…The effect of the neuropeptide, substance P, on the transport of d-[ 3H]aspartate into rat striatal synaptosomes was studied. Almost 90% of the total transport…”
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Reduction of striatal N-methyl-D-aspartate toxicity by inhibition of nitric oxide synthase by Kollegger, H, McBean, G J, Tipton, K F

“…Coronal slices of rat brain were incubated for 40 min in 300 microM kainate (KA) or 500 microM N-methyl-D-aspartate (NMDA). Histological examination showed…”
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Intrastriatal injection of DL-alpha-aminoadipate reduces kainate toxicity in vitro by McBean, G J

“…Intrastriatal injection of the excitatory amino acid analogue DL-alpha-aminoadipate (100 micrograms in 2 microliters saline, pH 7.4) into anesthetized rats…”
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Alteration in the glial cell metabolism of glutamate by kainate and N-methyl-D-aspartate by McBean, G.J., Doorty, K.B., Tipton, K.F., Kollegger, H.

“…Incubation of coronal slices of rat brain with neurotoxic concentrations of kainate (300 μM) and N-methyl-D-aspartate (NMDA; 500 μM) for 40 min reduced the…”
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Pre-incubation of synaptosomes with arachidonic acid potentiates inhibition of [ 3H] D-aspartate transport by Lundy, Denise F., McBean, Gethin J.

“…The ability of low micromolar concentrations of the polyunsaturated fatty acid, arachidonic acid (cis-5,8,11,14-eicosatetraenoic acid) to inhibit the…”
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Inhibition of the high-affinity uptake of d-[ 3H]aspartate in rat brain by l-α-aminoadipate and arachidonic acid by Lundy, Denise F., McBean, Gethin J.

“…The mechanism of inhibition of the high-affinity sodium-dependent transport of d-[ 3H]aspartate by the gliotoxin, l-α-aminoadipate, and also by the endogenous…”
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Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum by McBean, G J, Roberts, P J

“…Destruction of the glutamatergic corticostriatal pathway potentiates the neurotoxic action of 1 mumol L-glutamate injected into the rat striatum, whereas the…”
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The inhibition of glutamine synthetase in rat corpus striatum in vitro by methionine sulfoximine increases the neurotoxic effects of kainate and N-methyl-D-aspartate by Kollegger, H, McBean, G J, Tipton, K F

“…Coronal slices of rat brain were incubated in Krebs bicarbonate medium containing kainate (300 microM), or N-methyl-D-aspartate (500 microM). Degeneration of…”
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Differential modulation of the glutamate transporters GLT1, GLAST and EAAC1 by docosahexaenoic acid by Berry, Colm B., Hayes, Derek, Murphy, Andrew, Wießner, Michael, Rauen, Thomas, McBean, Gethin J.

“…At present, the ability of polyunsaturated fatty acids (PUFAs) to regulate individual glutamate transporter subtypes is poorly understood and very little…”
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Transport of l-[ 14C]cystine and l-[ 14C]cysteine by subtypes of high affinity glutamate transporters over-expressed in HEK cells by Hayes, Derek, Wießner, Michael, Rauen, Thomas, McBean, Gethin J.

“…Transport of l-cystine across the cell membrane is essential for synthesis of the major cellular antioxidant, glutathione (γ-glutamylcysteinylglycine). In this…”
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Blockade of noradrenaline transport abolishes 4-methylthioamphetamine-induced contraction of the rat aorta in vitro by Quinn, S T, Guiry, P J, Schwab, T, Keenan, A K, McBean, G J

“…The aim of this study was to characterize the effects of 4-methylthioamphetamine (4-MTA) on contractility and noradrenaline (NA) transport and release in the…”
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Chronic infusion of L-glutamate causes neurotoxicity in rat striatum by McBean, G J, Roberts, P J

“…Chronic infusion of a high dose of monosodium glutamate (approximately 8 nmol/min) into the rat left striatum, over a period of 1 week, caused degeneration of…”
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An investigation into the role of calcium in the modulation of rat synaptosomal d-[ 3H]aspartate transport by docosahexaenoic acid by Berry, Colm B., McBean, Gethin J.

“…The effect of the polyunsaturated fatty acid cis-4,7,10,13,16,19-docosahexaenoic acid (DHA) on the high-affinity, sodium-dependent uptake of d-[ 3H]aspartate…”
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An NMR study of alterations in [1- [formula omitted]]glucose metabolism in C6 glioma cells by gliotoxic amino acids by Brennan, Lorraine, Hewage, Chandralal, Malthouse, J.Paul G., McBean, Gethin J.

“…A series of glutamate analogues, known as gliotoxins, are toxic to astrocytes in culture, and are inhibitors or substrates of high affinity sodium-dependent…”
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