Search Results - "McAusland, Thomas M."

Recombinant Newcastle disease viruses expressing immunological checkpoint inhibitors induce a pro-inflammatory state and enhance tumor-specific immune responses in two murine models of cancer by Santry, Lisa A, van Vloten, Jacob P, AuYeung, Amanda W K, Mould, Robert C, Yates, Jacob G E, McAusland, Thomas M, Petrik, James J, Major, Pierre P, Bridle, Byram W, Wootton, Sarah K

“…Tumor microenvironments are immunosuppressive due to progressive accumulation of mutations in cancer cells that can drive expression of a range of inhibitory…”
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Interference chromatography: a novel approach to optimizing chromatographic selectivity and separation performance for virus purification by Santry, Lisa A, Jacquemart, Renaud, Vandersluis, Melissa, Zhao, Mochao, Domm, Jake M, McAusland, Thomas M, Shang, Xiaojiao, Major, Pierre M, Stout, James G, Wootton, Sarah K

“…Oncolytic viruses are playing an increasingly important role in cancer immunotherapy applications. Given the preclinical and clinical efficacy of these…”
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Production and Purification of High-Titer Newcastle Disease Virus for Use in Preclinical Mouse Models of Cancer by Santry, Lisa A, McAusland, Thomas M, Susta, Leonardo, Wood, Geoffrey A, Major, Pierre P, Petrik, Jim J, Bridle, Byram W, Wootton, Sarah K

“…Newcastle disease virus (NDV) is a single-stranded, negative-sense RNA virus in the family. Although primarily an avian pathogen, NDV is a potent oncolytic…”
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Oncolytic Orf virus licenses NK cells via cDC1 to activate innate and adaptive antitumor mechanisms and extends survival in a murine model of late-stage ovarian cancer by van Vloten, Jacob P, Matuszewska, Kathy, Minow, Mark A A, Minott, Jessica A, Santry, Lisa A, Pereira, Madison, Stegelmeier, Ashley A, McAusland, Thomas M, Klafuric, Elaine M, Karimi, Khalil, Colasanti, Joseph, McFadden, D Grant, Petrik, James J, Bridle, Byram W, Wootton, Sarah K

“…BackgroundNovel therapies are needed to improve outcomes for women diagnosed with ovarian cancer. Oncolytic viruses are multifunctional immunotherapeutic…”
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Production and purification of high-titer OrfV for preclinical studies in vaccinology and cancer therapy by van Vloten, Jacob P., Minott, Jessica A., McAusland, Thomas M., Ingrao, Joelle C., Santry, Lisa A., McFadden, Grant, Petrik, James J., Bridle, Byram W., Wootton, Sarah K.

“…Poxviruses have been used extensively as vaccine vectors for human and veterinary medicine and have recently entered the clinical realm as immunotherapies for…”
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Combining vanadyl sulfate with Newcastle disease virus potentiates rapid innate immune-mediated regression with curative potential in murine cancer models by McAusland, Thomas M., van Vloten, Jacob P., Santry, Lisa A., Guilleman, Matthew M., Rghei, Amira D., Ferreira, Edgar M., Ingrao, Joelle C., Arulanandam, Rozanne, Major, Pierre P., Susta, Leonardo, Karimi, Khalil, Diallo, Jean-Simon, Bridle, Byram W., Wootton, Sarah K.

“…The avian paramyxovirus, Newcastle disease virus (NDV), is a promising oncolytic agent that has been shown to be safe and effective in a variety of…”
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Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies by van Vloten, Jacob P., Santry, Lisa A., McAusland, Thomas M., Karimi, Khalil, McFadden, Grant, Petrik, James J., Wootton, Sarah K., Bridle, Byram W.

“…Immunotherapies are at the forefront of the fight against cancers, and researchers continue to develop and test novel immunotherapeutic modalities. Ideal…”
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Tumour vasculature: Friend or foe of oncolytic viruses? by Santry, Lisa A., van Vloten, Jacob P., Knapp, Jason P., Matuszewska, Kathy, McAusland, Thomas M., Minott, Jessica A., Mould, Robert C., Stegelmeier, Ashley A., Major, Pierre P., Wootton, Sarah K., Petrik, James J., Bridle, Byram W.

“…In the past two decades there have been substantial advances in understanding the anti-cancer mechanisms of oncolytic viruses (OVs). OVs can mediate their…”
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