Search Results - "McAuliffe, Malia"

Substituted (Pyridylmethoxy)naphthalenes as Potent and Orally Active 5-Lipoxygenase Inhibitors:  Synthesis, Biological Profile, and Pharmacokinetics of L-739,010 by Hamel, Pierre, Riendeau, Denis, Brideau, Christine, Chan, Chi-Chung, Desmarais, Sylvie, Delorme, Daniel, Dubé, Daniel, Ducharme, Yves, Ethier, Diane, Grimm, Erich, Falgueyret, Jean-Pierre, Guay, Jocelyne, Jones, Tom R, Kwong, Elizabeth, McFarlane, Cyril S, Piechuta, Hanna, Roumi, Marie, Tagari, Philip, Young, Robert N, Girard, Yves

“…Dioxabicyclooctanyl naphthalenenitriles have been reported as a class of potent and nonredox 5-lipoxygenase (5-LO) inhibitors. These bicyclo derivatives were…”
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Discovery of a Potent and Selective Prostaglandin D 2 Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524) by Sturino, Claudio F., O'Neill, Gary, Lachance, Nicolas, Boyd, Michael, Berthelette, Carl, Labelle, Marc, Li, Lianhai, Roy, Bruno, Scheigetz, John, Tsou, Nancy, Aubin, Yves, Bateman, Kevin P., Chauret, Nathalie, Day, Stephen H., Lévesque, Jean-François, Seto, Carmai, Silva, Jose H., Trimble, Laird A., Carriere, Marie-Claude, Denis, Danielle, Greig, Gillian, Kargman, Stacia, Lamontagne, Sonia, Mathieu, Marie-Claude, Sawyer, Nicole, Slipetz, Deborah, Abraham, William M., Jones, Tom, McAuliffe, Malia, Piechuta, Hana, Nicoll-Griffith, Deborah A., Wang, Zhaoyin, Zamboni, Robert, Young, Robert N., Metters, Kathleen M.

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Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524) by Sturino, Claudio F, O'Neill, Gary, Lachance, Nicolas, Boyd, Michael, Berthelette, Carl, Labelle, Marc, Li, Lianhai, Roy, Bruno, Scheigetz, John, Tsou, Nancy, Aubin, Yves, Bateman, Kevin P, Chauret, Nathalie, Day, Stephen H, Lévesque, Jean-François, Seto, Carmai, Silva, Jose H, Trimble, Laird A, Carriere, Marie-Claude, Denis, Danielle, Greig, Gillian, Kargman, Stacia, Lamontagne, Sonia, Mathieu, Marie-Claude, Sawyer, Nicole, Slipetz, Deborah, Abraham, William M, Jones, Tom, McAuliffe, Malia, Piechuta, Hana, Nicoll-Griffith, Deborah A, Wang, Zhaoyin, Zamboni, Robert, Young, Robert N, Metters, Kathleen M

“…The discovery of the potent and selective prostaglandin D2 (PGD2) receptor (DP) antagonist…”
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Substituted 4-(2,2-diphenylethyl)pyridine-n-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters by FRENETTE, Richard, BLOUIN, Marc, MASSON, Paul, MCAULIFFE, Malia, GIRARD, Yves, BRIDEAU, Christine, CHAURET, Nathalie, DUCHARME, Yves, FRIESEN, Richard W, HAMEL, Pierre, JONES, Tom R, LALIBERTE, France, CHUN LI

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Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor by Guay, Daniel, Hamel, Pierre, Blouin, Marc, Brideau, Christine, Chan, Chi Chung, Chauret, Nathalie, Ducharme, Yves, Huang, Zheng, Girard, Mario, Jones, Tom R., Laliberté, France, Masson, Paul, McAuliffe, Malia, Piechuta, Hanna, Silva, José, Young, Robert N., Girard, Yves

“…Structure–activity relationship studies directed toward improving the potency and metabolic stability of CDP-840 ( 3) resulted in the discovery of L-791,943 (…”
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Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters by Frenette, Richard, Blouin, Marc, Brideau, Christine, Chauret, Nathalie, Ducharme, Yves, Friesen, Richard W, Hamel, Pierre, Jones, Tom R, Laliberté, France, Li, Chun, Masson, Paul, McAuliffe, Malia, Girard, Yves

“…A detailed SAR study directed toward the optimization of pharmacokinetic parameters for analogues of L-791,943 is reported. The introduction of a soft…”
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Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors:  Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability by Delorme, Daniel, Ducharme, Yves, Brideau, Christine, Chan, Chi-Chung, Chauret, Nathalie, Desmarais, Sylvie, Dubé, Daniel, Falgueyret, Jean-Pierre, Fortin, Réjean, Guay, Jocelyne, Hamel, Pierre, Jones, Tom R, Lépine, Carole, Li, Chun, McAuliffe, Malia, McFarlane, Cyril S, Nicoll-Griffith, Deborah A, Riendeau, Denis, Yergey, James A, Girard, Yves

“…Naphthalenic lignan lactone 3a (L-702,539), a potent and selective 5-lipoxygenase (5-LO) inhibitor, is extensively metabolized at two different sites:  the…”
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Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors by Frenette, Richard, Hutchinson, John H., Léger, Serge, Thérien, Michel, Brideau, Christine, Chan, Chi C., Charleson, Stella, Ethier, Diane, Guay, Jocelyne, Jones, Tom R., McAuliffe, Malia, Piechuta, Hanna, Riendeau, Denis, Tagari, Philip, Girard, Yves

“…This paper reports on the SAR investigation of inhibitors of 5-lipoxygenase activating protein (FLAP) based on MK-0591. Emphasis was made on modifications to…”
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