Search Results - "McAuley, Danny"

Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS by Dutra Silva, Johnatas, Su, Yue, Calfee, Carolyn S, Delucchi, Kevin L, Weiss, Daniel, McAuley, Danny F, O'Kane, Cecilia, Krasnodembskaya, Anna D

“…Alveolar epithelial-capillary barrier disruption is a hallmark of acute respiratory distress syndrome (ARDS). Contribution of mitochondrial dysfunction to the…”
Get full text

Respiratory follow-up of patients with COVID-19 pneumonia by George, Peter M, Barratt, Shaney L, Condliffe, Robin, Desai, Sujal R, Devaraj, Anand, Forrest, Ian, Gibbons, Michael A, Hart, Nicholas, Jenkins, R Gisli, McAuley, Danny F, Patel, Brijesh V, Thwaite, Erica, Spencer, Lisa G

“…The COVID-19 pandemic has led to an unprecedented surge in hospitalised patients with viral pneumonia. The most severely affected patients are older men,…”
Get more information

Mechanical Ventilation for Acute Respiratory Distress Syndrome during Extracorporeal Life Support. Research and Practice by Abrams, Darryl, Schmidt, Matthieu, Pham, Tài, Beitler, Jeremy R, Fan, Eddy, Goligher, Ewan C, McNamee, James J, Patroniti, Nicolò, Wilcox, M Elizabeth, Combes, Alain, Ferguson, Niall D, McAuley, Danny F, Pesenti, Antonio, Quintel, Michael, Fraser, John, Hodgson, Carol L, Hough, Catherine L, Mercat, Alain, Mueller, Thomas, Pellegrino, Vin, Ranieri, V Marco, Rowan, Kathy, Shekar, Kiran, Brochard, Laurent, Brodie, Daniel

“…Ventilator-induced lung injury remains a key contributor to the morbidity and mortality of acute respiratory distress syndrome (ARDS). Efforts to minimize this…”
Get full text

Respiratory viral infection: a potential "missing link" in the pathogenesis of COPD by Linden, Dermot, Guo-Parke, Hong, Coyle, Peter V, Fairley, Derek, McAuley, Danny F, Taggart, Clifford C, Kidney, Joe

“…Chronic obstructive pulmonary disease (COPD) is currently the third most common cause of global mortality. Acute exacerbations of COPD frequently necessitate…”
Get full text

Acute Respiratory Distress Syndrome Subphenotypes beyond the Syndrome: A Step toward Treatable Traits? by Reddy, Kiran, Calfee, Carolyn S., McAuley, Danny F.

“…Reddy et al discuss the study by Heijnen and colleagues which support the concept that treatable traits in critical illness are independent of syndromic…”
Get full text

A minimal common outcome measure set for COVID-19 clinical research by Marshall, John C, Murthy, Srinivas, Diaz, Janet, Adhikari, N K, Angus, Derek C, Arabi, Yaseen M, Baillie, Kenneth, Bauer, Michael, Berry, Scott, Blackwood, Bronagh, Bonten, Marc, Bozza, Fernando, Brunkhorst, Frank, Cheng, Allen, Clarke, Mike, Dat, Vu Quoc, de Jong, Menno, Denholm, Justin, Derde, Lennie, Dunning, Jake, Feng, Xiaobin, Fletcher, Tom, Foster, Nadine, Fowler, Rob, Gobat, Nina, Gomersall, Charles, Gordon, Anthony, Glueck, Thomas, Harhay, Michael, Hodgson, Carol, Horby, Peter, Kim, YaeJean, Kojan, Richard, Kumar, Bharath, Laffey, John, Malvey, Denis, Martin-Loeches, Ignacio, McArthur, Colin, McAuley, Danny, McBride, Stephen, McGuinness, Shay, Merson, Laura, Morpeth, Susan, Needham, Dale, Netea, Mihai, Oh, Myoung-Don, Phyu, Sabai, Piva, Simone, Qiu, Ruijin, Salisu-Kabara, Halima, Shi, Lei, Shimizu, Naoki, Sinclair, Jorge, Tong, Steven, Turgeon, Alexis, Uyeki, Tim, van de Veerdonk, Frank, Webb, Steve, Williamson, Paula, Wolf, Timo, Zhang, Junhua

“…Clinical research is necessary for an effective response to an emerging infectious disease outbreak. However, research efforts are often hastily organised and…”
Get full text

Fool’s gold? Why blinded trials are not always best by Anand, Rohan, Norrie, John, Bradley, Judy M, McAuley, Danny F, Clarke, Mike

“…Blinding is intended to reduce bias but can make studies unnecessarily complex or lead to results that no longer address the clinical question, argue Rohan…”
Get full text

Extracorporeal carbon dioxide removal compared to ventilation alone in patients with acute hypoxaemic respiratory failure: cost-utility analysis of the REST RCT by Agus, Ashley, McNamee, James J., Jackson, Colette, McAuley, Danny F.

“…Background Acute hypoxaemic respiratory failure requiring mechanical ventilation is a major cause of morbidity and mortality and has significant resource…”
Get full text

A New Global Definition of Acute Respiratory Distress Syndrome by Matthay, Michael A, Arabi, Yaseen, Arroliga, Alejandro C, Bernard, Gordon, Bersten, Andrew D, Brochard, Laurent J, Calfee, Carolyn S, Combes, Alain, Daniel, Brian M, Ferguson, Niall D, Gong, Michelle N, Gotts, Jeffrey E, Herridge, Margaret S, Laffey, John G, Liu, Kathleen D, Machado, Flavia R, Martin, Thomas R, McAuley, Danny F, Mercat, Alain, Moss, Marc, Mularski, Richard A, Pesenti, Antonio, Qiu, Haibo, Ramakrishnan, Nagarajan, Ranieri, V Marco, Riviello, Elisabeth D, Rubin, Eileen, Slutsky, Arthur S, Thompson, B Taylor, Twagirumugabe, Theogene, Ware, Lorraine B, Wick, Katherine D

“…Since publication of the 2012 Berlin definition of acute respiratory distress syndrome (ARDS), several developments have supported the need for an expansion of…”
Get full text

Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children: a cochrane systematic review and meta-analysis by Rose, Louise, Schultz, Marcus J, Cardwell, Chris R, Jouvet, Philippe, McAuley, Danny F, Blackwood, Bronagh

“…Automated weaning systems may improve adaptation of mechanical support for a patient's ventilatory needs and facilitate systematic and early recognition of…”
Get full text

Reply to Aberegg and Wolfe: Aspergillosis in the ICU: Hidden Enemy or Bogeyman? by Loughlin, Laura, McAuley, Danny F, Simpson, A John, McMullan, Ronan

Get full text

Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study by van Haren, Frank, Pham, Tài, Brochard, Laurent, Bellani, Giacomo, Laffey, John, Dres, Martin, Fan, Eddy, Goligher, Ewan C., Heunks, Leo, Lynch, Joan, Wrigge, Hermann, McAuley, Danny

“…OBJECTIVES:To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to…”
Get full text

Pulmonary Aspergillosis in Patients with Suspected Ventilator-associated Pneumonia in UK ICUs by Loughlin, Laura, Hellyer, Thomas P, White, P Lewis, McAuley, Danny F, Conway Morris, Andrew, Posso, Raquel B, Richardson, Malcolm D, Denning, David W, Simpson, A John, McMullan, Ronan

“…infection in patients with suspected ventilator-associated pneumonia remains uncharacterized because of the absence of a disease definition and limited access…”
Get full text

The effect of blood pressure on mortality following out-of-hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database by McGuigan, Peter J, Giallongo, Elisa, Blackwood, Bronagh, Doidge, James, Harrison, David A, Nichol, Alistair D, Rowan, Kathryn M, Shankar-Hari, Manu, Skrifvars, Markus B, Thomas, Karen, McAuley, Danny F

“…Hypotension following out-of-hospital cardiac arrest (OHCA) may cause secondary brain injury and increase mortality rates. Current guidelines recommend…”
Get full text

High-volume haemofiltration for sepsis in adults by Borthwick, Emma Mj, Hill, Christopher J, Rabindranath, Kannaiyan S, Maxwell, Alexander P, McAuley, Danny F, Blackwood, Bronagh

“…Severe sepsis and septic shock are leading causes of death in the intensive care unit (ICU), despite advances in the treatment of patients with severe sepsis…”
Get more information

Evidence for chemokine synergy during neutrophil migration in ARDS by Williams, Andrew E, José, Ricardo J, Mercer, Paul F, Brealey, David, Parekh, Dhruv, Thickett, David R, O'Kane, Cecelia, McAuley, Danny F, Chambers, Rachel C

“…Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterised by pulmonary oedema, respiratory failure and severe inflammation. ARDS…”
Get more information

Variation in Definition of Prolonged Mechanical Ventilation by Rose, Louise, McGinlay, Michael, Amin, Reshma, Burns, Karen Ea, Connolly, Bronwen, Hart, Nicholas, Jouvet, Philippe, Katz, Sherri, Leasa, David, Mawdsley, Cathy, McAuley, Danny F, Schultz, Marcus J, Blackwood, Bronagh

“…Consistency of definitional criteria for terminology applied to describe subject cohorts receiving mechanical ventilation within ICU and post-acute care…”
Get full text

Management of new onset atrial fibrillation in critically unwell adult patients: a systematic review and narrative synthesis by Johnston, Brian W, Chean, Chung S, Duarte, Rui, Hill, Ruaraidh, Blackwood, Bronagh, McAuley, Danny F, Welters, Ingeborg D

“…New onset atrial fibrillation (NOAF) is the most common arrhythmia affecting critically unwell patients. NOAF can lead to worsening haemodynamic compromise,…”
Get more information

The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study by McGuigan, Peter J, Shankar-Hari, Manu, Harrison, David A, Laffey, John G, McAuley, Danny F

“…Outcomes following out of hospital cardiac arrest (OHCA) are poor. The optimal arterial oxygen and carbon dioxide (PaCO ) levels for managing patients…”
Get full text

Delivery of a novel intervention to facilitate liberation from mechanical ventilation in paediatric intensive care: A process evaluation by Jordan, Joanne, Tume, Lyvonne, Clarke, Mike, McAuley, Danny, McDowell, Cliona, McIlmurray, Lisa, Morris, Kevin, Peters, Mark, Walsh, Timothy, Blackwood, Bronagh

“…Background Prolonged mechanical ventilation increases the risk of mortality and morbidity. Optimising sedation and early testing for possible liberation from…”
Get full text