Search Results - "McAtee, Jeff"

Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement by Barton, Linda S., Callahan, James F., Cantizani, Juan, Concha, Nestor O., Cotillo Torrejon, Ignacio, Goodwin, Nicole C., Joshi-Pangu, Amruta, Kiesow, Terry J., McAtee, Jeff J., Mellinger, Mark, Nixon, Christopher J., Padrón-Barthe, Laura, Patterson, Jaclyn R., Pearson, Neil D., Pouliot, Jeffrey J., Rendina, Alan R., Buitrago Santanilla, Alexander, Schneck, Jessica L., Sanz, Olalla, Thalji, Reema K., Ward, Paris, Williams, Shawn P., King, Bryan W.

“…[Display omitted] •P1 analogues with aldehyde warhead prepared and tested against 3CLpro in SARS-CoV-2.•Discovery of 2-THF as P1 residue with potent inhibition…”
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Cassette dosing for pharmacokinetic screening in drug discovery: comparison of clearance, volume of distribution, half-life, mean residence time, and oral bioavailability obtained by cassette and discrete dosing in rats by Nagilla, Rakesh, Nord, Melanie, McAtee, Jeff J, Jolivette, Larry J

“…The purpose of this investigation was to compare selected pharmacokinetic (PK) parameters obtained by cassette and discrete dosing of compounds in rats. The…”
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Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase by Thalji, Reema K., McAtee, Jeff J., Belyanskaya, Svetlana, Brandt, Martin, Brown, Gregory D., Costell, Melissa H., Ding, Yun, Dodson, Jason W., Eisennagel, Steve H., Fries, Rusty E., Gross, Jeffrey W., Harpel, Mark R., Holt, Dennis A., Israel, David I., Jolivette, Larry J., Krosky, Daniel, Li, Hu, Lu, Quinn, Mandichak, Tracy, Roethke, Theresa, Schnackenberg, Christine G., Schwartz, Benjamin, Shewchuk, Lisa M., Xie, Wensheng, Behm, David J., Douglas, Stephen A., Shaw, Ami L., Marino, Joseph P.

“…1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were identified from high through-put screening using encoded library…”
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The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore by Washburn, David G., Holt, Dennis A., Dodson, Jason, McAtee, Jeff J., Terrell, Lamont R., Barton, Linda, Manns, Sharada, Waszkiewicz, Anna, Pritchard, Christina, Gillie, Dan J., Morrow, Dwight M., Davenport, Elizabeth A., Lozinskaya, Irina M., Guss, Jeffrey, Basilla, Jonathan B., Negron, Lorena Kallal, Klein, Michael, Willette, Robert N., Fries, Rusty E., Jensen, Timothy C., Xu, Xiaoping, Schnackenberg, Christine G., Marino, Joseph P.

“…Lead optimization of piperidine amide HTS hits, based on an anilino-thiazole core, led to the identification of analogs which displayed low nanomolar blocking…”
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Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid‑4 (TRPV4) by Brnardic, Edward J, Ye, Guosen, Brooks, Carl, Donatelli, Carla, Barton, Linda, McAtee, Jeff, Sanchez, Robert M, Shu, Arthur, Erhard, Karl, Terrell, Lamont, Graczyk-Millbrandt, Grazyna, He, Yanan, Costell, Melissa H, Behm, David J, Roethke, Theresa, Stoy, Patrick, Holt, Dennis A, Lawhorn, Brian G

“…A novel series of pyrrolidine sulfonamide transient receptor potential vanilloid-4 (TRPV4) antagonists was developed by modification of a previously reported…”
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