Search Results - "McArthur, Robert A."

Aligning physiology with psychology: Translational neuroscience in neuropsychiatric drug discovery by McArthur, Robert A.

“…•Reproducibility of preclinical results, placebo response and publication bias contribute to neuropsychiatric drug attrition.•Emphasis on psychometric…”
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Animal and translational models for CNS drug discovery by McArthur, Robert A, Borsini, Franco

“…Animal and Translational Models for CNS Drug Discovery combines the experience of academic, clinical and pharmaceutical neuroscientists in a unique…”
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Synthesis and Anticonvulsant Activity of a New Class of 2-[(Arylalkyl)amino]alkanamide Derivatives by Pevarello, Paolo, Bonsignori, Alberto, Dostert, Philippe, Heidempergher, Franco, Pinciroli, Vittorio, Colombo, Maristella, McArthur, Robert A, Salvati, Patricia, Post, Claes, Fariello, Ruggero G, Varasi, Mario

“…Although most epilepsies are adequately treated by conventional antiepileptic therapy, there remains an unfulfilled need for safer and more effective…”
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PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat by Maj, Roberto, Fariello, Ruggero G, Ukmar, Giorgio, Varasi, Mario, Pevarello, Paolo, McArthur, Robert A, Salvati, Patricia

“…Kainic acid-induced multifocal status epilepticus in the rat is a model of medically intractable complex partial seizures and neurotoxicity. The exact…”
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Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor by Wong, Erik H.F., Sonders, Mark S., Amara, Susan G., Tinholt, Paula M., Piercey, Montford F.P., Hoffmann, William P., Hyslop, Deborah K., Franklin, Stanley, Porsolt, Roger D., Bonsignori, Alberto, Carfagna, Nicola, McArthur, Robert A.

“…Background: Reboxetine is a potent antidepressant, with efficacy comparable to that of imipramine, desipramine, and fluoxetine, and has improved side-effect…”
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Characterization of energy expenditure in rodents by indirect calorimetry by Alberts, Pēteris, Johansson, Bo G, McArthur, Robert A

“…The need for treatment of obesity and obesity-related diseases, such as type 2 diabetes, has been intensified by the epidemic rise of obesity. Recent advances…”
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Measurement and characterization of energy intake in the mouse by Svartengren, Jan, Modiri, Ali-Reza, McArthur, Robert A

“…Because of the dramatic increase in obesity and related conditions, such as type 2 diabetes, efforts have intensified to develop medications to assist in…”
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Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol by ROBERTS, A. J, MCARTHUR, R. A, HULL, E. E, POST, C, KOOB, G. F

“…Both 5-HT1A and 5-HT2A receptors have been implicated in modulating ethanol self-administration. A novel serotonergic compound, FG 5974, with combined 5-HT1A…”
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Measurement and characterization of energy expenditure as a tool in the development of drugs for metabolic diseases, such as obesity and diabetes by Alberts, Pēteris, Johansson, Bo G, McArthur, Robert A

“…The need for treatment of obesity and obesity-related diseases, such as type 2 diabetes, has been intensified by the epidemic rise of obesity. Recent advances…”
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Structure−Activity Relationship Studies on the 5-HT1A Receptor Affinity of 1-Phenyl-4-[ω-(α- or β-tetralinyl)alkyl]piperazines. 4 by Perrone, Roberto, Berardi, Francesco, Colabufo, Nicola A, Leopoldo, Marcello, Tortorella, Vincenzo, Fornaretto, Maria Gioia, Caccia, Carla, McArthur, Robert A

“…The synthesis of 1-phenylpiperazines, linked in the α or β position of the tetralin moiety on the terminal part of the N-4 alkyl chain, and their radioligand…”
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Anticonvulsant Activity of PNU‐151774E 1 in the Amygdala Kindled Model of Complex Partial Seizures by Maj, Roberto, Fariello, Ruggero G., Pevarello, Paolo, Varasi, Mario, McArthur, Robert A., Salvati, Patricia

“…Purpose: PNU‐151774E [(S)‐(+)‐2‐(4‐(3‐fluoro‐benzyloxy) benzylamino) propanamide, methanesulfonate] is a novel antiepileptic drug (AED) with a broad spectrum…”
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1-Aryl-4-[(1-tetralinyl)alkyl]piperazines:  Alkylamido and Alkylamino Derivatives. Synthesis, 5-HT1A Receptor Affinity, and Selectivity. 3 by Perrone, Roberto, Berardi, Francesco, Leopoldo, Marcello, Tortorella, Vincenzo, Fornaretto, Maria Gioia, Caccia, Carla, McArthur, Robert A

“…The synthesis and binding profile on 5-HT1A, 5-HT2, D-1, D-2, α1, and α2 receptors of the N-4 long-chain arylpiperazines 22−40 are reported, where an amino or…”
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Selective Inhibition of Alcohol Intake in Diverse Alcohol-Preferring Rat Strains by the 5-HT2A Antagonists Amperozide and FG 5974 by Overstreet, David H., McArthur, Robert A., Rezvani, Amir H., Post, Claes

“…The present studies sought to elucidate the role of 5‐HT2A receptor antagonists in suppressing alcohol intake by comparing the effects of amperozide and FG…”
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Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures by MAJ, R, FARIELLO, R. G, PEVARELLO, P, VARASI, M, MCARTHUR, R. A, SALVATI, P

“…PNU-151774E [(S)-(+)-2-(4-(3-fluorobenzyloxy) benzylamino) propanamide, methanesulfonate] is a novel antiepileptic drug (AED) with a broad spectrum of activity…”
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Anticonvulsant Activity of PNU‐151774E1 in the Amygdala Kindled Model of Complex Partial Seizures by Maj, Roberto, Fariello, Ruggero G., Pevarello, Paolo, Varasi, Mario, McArthur, Robert A., Salvati, Patricia

“…Purpose: PNU‐151774E [(S)‐(+)‐2‐(4‐(3‐fluoro‐benzyloxy) benzylamino) propanamide, methanesulfonate] is a novel antiepileptic drug (AED) with a broad spectrum…”
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Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants by Pevarello, Paolo, Bonsignori, Alberto, Caccia, Carla, Amici, Raffaella, McArthur, Robert A., Fariello, Ruggero G., Salvati, Patricia, Varasi, Mario

“…Sodium channel blocking, anticonvulsant activity, and sigma (σ) binding of selected leads in a series of α-amino amide anticonvulsants were examined. While…”
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Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4 by Perrone, R, Berardi, F, Colabufo, N A, Leopoldo, M, Tortorella, V, Fornaretto, M G, Caccia, C, McArthur, R A

“…The synthesis of 1-phenylpiperazines, linked in the alpha or beta position of the tetralin moiety on the terminal part of the N-4 alkyl chain, and their…”
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Synthesis and preliminary biological evaluation of new α-amino amide anticonvulsants incorporating a dextromethorphan moiety by Pevarello, Paolo, Traquandi, Gabriella, Bonsignori, Alberto, McArthur, Robert A., Maj, Roberto, Caccia, Carla, Salvati, Patricia, Varasi, Mario

“…Dextromethorphan 1 is an effective neuroprotectant in animal models of epilepsy and ischemia but showed side-effects during clinical trials limiting its…”
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Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials by McArthur, Robert A, Gray, Julian, Schreiber, Rudy

“…The limited effect of AChE inhibitors and NMDA receptor antagonists for the treatment of the cognitive symptoms of Alzheimer's disease has prompted the search…”
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Selective Inhibition of Alcohol Intake in Diverse Alcohol‐Preferring Rat Strains by the 5‐HT 2A Antagonists Amperozide and FG 5974 by Overstreet, David H., McArthur, Robert A., Rezvani, Amir H., Post, Claes

“…The present studies sought to elucidate the role of 5‐HT 2A receptor antagonists in suppressing alcohol intake by comparing the effects of amperozide and FG…”
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