Search Results - "McArthur, Mark"
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Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers
Published in Cell (07-03-2019)“…Cancers from sun-exposed skin accumulate “driver” mutations, causally implicated in oncogenesis. Because errors incorporated during translesion synthesis (TLS)…”
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2
Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression
Published in Cancer discovery (01-01-2016)“…The signaling mechanisms between prostate cancer cells and infiltrating immune cells may illuminate novel therapeutic approaches. Here, utilizing a prostate…”
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3
Prolonged myelination in human neocortical evolution
Published in Proceedings of the National Academy of Sciences - PNAS (09-10-2012)“…Nerve myelination facilitates saltatory action potential conduction and exhibits spatiotemporal variation during development associated with the acquisition of…”
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4
Preclinical Mammalian Safety Studies of EPHARNA (DOPC Nanoliposomal EphA2-Targeted siRNA)
Published in Molecular cancer therapeutics (01-06-2017)“…To address the need for efficient and biocompatible delivery systems for systemic siRNA delivery, we developed 1,2-Dioleoyl-sn-Glycero-3-Phosphatidylcholine…”
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5
Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein
Published in Genes & development (15-09-2017)“…is the most frequently mutated gene in human cancer. Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that contribute to metastasis,…”
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Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast Cancer
Published in Molecular cancer therapeutics (01-04-2016)“…Triple-negative breast cancer (TNBC) is an aggressive malignancy in which the tumors lack expression of estrogen receptor, progesterone receptor, and HER2…”
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Synaptogenesis and development of pyramidal neuron dendritic morphology in the chimpanzee neocortex resembles humans
Published in Proceedings of the National Academy of Sciences - PNAS (18-06-2013)“…Neocortical development in humans is characterized by an extended period of synaptic proliferation that peaks in mid-childhood, with subsequent pruning through…”
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8
Direct electrochemical regeneration of enzymatic cofactor 1,4‐NADH on a cathode composed of multi‐walled carbon nanotubes decorated with nickel nanoparticles
Published in Canadian journal of chemical engineering (01-01-2018)“…Multi‐walled carbon nanotubes (MWCNTs) were grown on a stainless steel mesh and decorated with nickel nanoparticles (Ni NPs). The developed Ni NP‐MWCNT…”
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9
Iridium-ruthenium-oxide coatings for supercapacitors
Published in Canadian journal of chemical engineering (01-11-2015)“…Electrochemical, topographical, and morphological properties of thermally‐prepared Irx‐Ru1‐x‐oxide coatings of various compositions (0 < x ≤ 1), formed on a Ti…”
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10
Rare primary hepatic malignancies: A case-based review
Published in Clinical imaging (01-01-2021)“…The two most common primary liver malignancies that radiologists encounter in clinical practice are hepatocellular carcinoma (HCC) and intrahepatic…”
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11
Dendritic morphology of pyramidal neurons in the chimpanzee neocortex: regional specializations and comparison to humans
Published in Cerebral cortex (New York, N.Y. 1991) (01-10-2013)“…The primate cerebral cortex is characterized by regional variation in the structure of pyramidal neurons, with more complex dendritic arbors and greater spine…”
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12
Safety and Efficacy of an Absorbable Filter in the Inferior Vena Cava to Prevent Pulmonary Embolism in Swine
Published in Radiology (01-12-2017)“…Purpose To evaluate the immediate and long-term safety as well as thrombus-capturing efficacy for 5 weeks after implantation of an absorbable inferior vena…”
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13
Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma
Published in Cancer prevention research (Philadelphia, Pa.) (01-03-2021)“…We have previously demonstrated that PD-1 blockade decreased the incidence of high-grade dysplasia in a carcinogen-induced murine model of oral squamous cell…”
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A binder‐free Ir0.4Ru0.6‐oxide/functionalized multi‐walled carbon nanotube electrode for possible applications in supercapacitors
Published in Canadian journal of chemical engineering (01-01-2018)“…An initial study on a simple and inexpensive method to form an Ir0.4Ru0.6‐oxide (MMO) coating onto high‐area plasma functionalized multi‐walled carbon…”
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15
The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis
Published in BMC cancer (22-09-2008)“…Overexpression of the bZip transcription factor, ATF3, in basal epithelial cells of transgenic mice under the control of the bovine cytokeratin-5 (CK5)…”
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16
Developmental changes in the spatial organization of neurons in the neocortex of humans and common chimpanzees
Published in Journal of comparative neurology (1911) (15-12-2013)“…ABSTRACT In adult humans the prefrontal cortex possesses wider minicolumns and more neuropil space than other cortical regions. These aspects of prefrontal…”
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17
In vivo biocompatibility and in vitro efficacy of antimicrobial gendine-coated central catheters
Published in Antimicrobial agents and chemotherapy (01-09-2015)“…Antimicrobial peripherally inserted central catheters (PICCs) might reduce the incidence of central line-associated bloodstream infections (CLABSI). We tested…”
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18
ATM Promotes Apoptosis and Suppresses Tumorigenesis in Response to Myc
Published in Proceedings of the National Academy of Sciences - PNAS (31-01-2006)“…Overexpression of the c-myc oncogene contributes to the development of a significant number of human cancers. In response to deregulated Myc activity, the p53…”
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19
Progressive Metaplastic and Dysplastic Changes in Mouse Pancreas Induced by Cyclooxygenase-2 Overexpression
Published in Neoplasia (New York, N.Y.) (01-08-2008)“…Cyclooxygenase-2 (COX-2) overexpression is an established factor linking chronic inflammation with metaplastic and neoplastic change in various tissues. We…”
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20
Mouse Models for the p53 R72P Polymorphism Mimic Human Phenotypes
Published in Cancer research (Chicago, Ill.) (15-07-2010)“…The p53 tumor suppressor gene contains a common single nucleotide polymorphism (SNP) that results in either an arginine or proline at position 72 of the p53…”
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