Search Results - "McArthur, Colin"

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 by Gordon, Anthony C, Mouncey, Paul R, Al-Beidh, Farah, Rowan, Kathryn M, Nichol, Alistair D, Arabi, Yaseen M, Annane, Djillali, Beane, Abi, van Bentum-Puijk, Wilma, Berry, Lindsay R, Bhimani, Zahra, Bonten, Marc J M, Bradbury, Charlotte A, Brunkhorst, Frank M, Buzgau, Adrian, Cheng, Allen C, Detry, Michelle A, Duffy, Eamon J, Estcourt, Lise J, Fitzgerald, Mark, Goossens, Herman, Haniffa, Rashan, Higgins, Alisa M, Hills, Thomas E, Horvat, Christopher M, Lamontagne, Francois, Lawler, Patrick R, Leavis, Helen L, Linstrum, Kelsey M, Litton, Edward, Lorenzi, Elizabeth, Marshall, John C, Mayr, Florian B, McAuley, Daniel F, McGlothlin, Anna, McGuinness, Shay P, McVerry, Bryan J, Montgomery, Stephanie K, Morpeth, Susan C, Murthy, Srinivas, Orr, Katrina, Parke, Rachael L, Parker, Jane C, Patanwala, Asad E, Pettilä, Ville, Rademaker, Emma, Santos, Marlene S, Saunders, Christina T, Seymour, Christopher W, Shankar-Hari, Manu, Sligl, Wendy I, Turgeon, Alexis F, Turner, Anne M, van de Veerdonk, Frank L, Zarychanski, Ryan, Green, Cameron, Lewis, Roger J, Angus, Derek C, McArthur, Colin J, Berry, Scott, Webb, Steve A, Derde, Lennie P G

“…The interleukin-6 receptor blockers tocilizumab and sarilumab were tested against standard care in a randomized trial involving patients newly admitted to the…”
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Early Sedation with Dexmedetomidine in Critically Ill Patients by Shehabi, Yahya, Howe, Belinda D, Bellomo, Rinaldo, Arabi, Yaseen M, Bailey, Michael, Bass, Frances E, Bin Kadiman, Suhaini, McArthur, Colin J, Murray, Lynnette, Reade, Michael C, Seppelt, Ian M, Takala, Jukka, Wise, Matt P, Webb, Steven A

“…In a randomized trial involving 4000 patients in the ICU who required sedation for mechanical ventilation, dexmedetomidine had no benefit on 90-day mortality…”
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The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design by Angus, Derek C, Berry, Scott, Lewis, Roger J, Al-Beidh, Farah, Arabi, Yaseen, van Bentum-Puijk, Wilma, Bhimani, Zahra, Bonten, Marc, Broglio, Kristine, Brunkhorst, Frank, Cheng, Allen C, Chiche, Jean-Daniel, De Jong, Menno, Detry, Michelle, Goossens, Herman, Gordon, Anthony, Green, Cameron, Higgins, Alisa M, Hullegie, Sebastiaan J, Kruger, Peter, Lamontagne, Francois, Litton, Edward, Marshall, John, McGlothlin, Anna, McGuinness, Shay, Mouncey, Paul, Murthy, Srinivas, Nichol, Alistair, O'Neill, Genevieve K, Parke, Rachael, Parker, Jane, Rohde, Gernot, Rowan, Kathryn, Turner, Anne, Young, Paul, Derde, Lennie, McArthur, Colin, Webb, Steven A

“…There is broad interest in improved methods to generate robust evidence regarding best practice, especially in settings where patient conditions are…”
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Glucocorticoid Dose in COVID-19: Lessons for Clinical Trials During a Pandemic by Webb, Steven A, Higgins, Alisa M, McArthur, Colin J

“…In this issue of JAMA, the COVID STEROID 2 Trial Group0 reports the results of an international, multicenter randomized clinical trial that compared 2…”
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Early intensive care sedation predicts long-term mortality in ventilated critically ill patients by Shehabi, Yahya, Bellomo, Rinaldo, Reade, Michael C, Bailey, Michael, Bass, Frances, Howe, Belinda, McArthur, Colin, Seppelt, Ian M, Webb, Steve, Weisbrodt, Leonie

“…Choice and intensity of early (first 48 h) sedation may affect short- and long-term outcome. To investigate the relationships between early sedation and time…”
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Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care by Myburgh, John A, Finfer, Simon, Bellomo, Rinaldo, Billot, Laurent, Cass, Alan, Gattas, David, Glass, Parisa, Lipman, Jeffrey, Liu, Bette, McArthur, Colin, McGuinness, Shay, Rajbhandari, Dorrilyn, Taylor, Colman B, Webb, Steven A.R

“…In a study of fluid resuscitation, patients received 6% hydroxyethyl starch (HES; 130/0.4) or saline until ICU discharge or death or for 90 days. There was no…”
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Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial by Young, Paul J, Bagshaw, Sean M, Forbes, Andrew B, Nichol, Alistair D, Wright, Stephen E, Bailey, Michael, Bellomo, Rinaldo, Beasley, Richard, Brickell, Kathy, Eastwood, Glenn M, Gattas, David J, van Haren, Frank, Litton, Edward, Mackle, Diane M, McArthur, Colin J, McGuinness, Shay P, Mouncey, Paul R, Navarra, Leanlove, Opgenorth, Dawn, Pilcher, David, Saxena, Manoj K, Webb, Steve A, Wiley, Daisy, Rowan, Kathryn M

“…IMPORTANCE: Proton pump inhibitors (PPIs) or histamine-2 receptor blockers (H2RBs) are often prescribed for patients as stress ulcer prophylaxis drugs in the…”
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Glycaemic control in diabetic ketoacidosis: Too much of a good thing? by McArthur, Colin

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Prehospital Tranexamic Acid for Severe Trauma by Gruen, Russell L, Mitra, Biswadev, Bernard, Stephen A, McArthur, Colin J, Burns, Brian, Gantner, Dashiell C, Maegele, Marc, Cameron, Peter A, Dicker, Bridget, Forbes, Andrew B, Hurford, Sally, Martin, Catherine A, Mazur, Stefan M, Medcalf, Robert L, Murray, Lynnette J, Myles, Paul S, Ng, Sze J, Pitt, Veronica, Rashford, Stephen, Reade, Michael C, Swain, Andrew H, Trapani, Tony, Young, Paul J

“…In this trial involving adults with major trauma, treatment with tranexamic acid did not result in a greater number of patients surviving with a favorable…”
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Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults by Cooper, D. James, McQuilten, Zoe K, Nichol, Alistair, Ady, Bridget, Aubron, Cécile, Bailey, Michael, Bellomo, Rinaldo, Gantner, Dashiell, Irving, David O, Kaukonen, Kirsi-Maija, McArthur, Colin, Murray, Lynne, Pettilä, Ville, French, Craig

“…In a large, blinded, randomized trial involving critically ill adults, no significant difference in 90-day mortality was noted between those who received red…”
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Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial by Nichol, Alistair, Prof, French, Craig, Dr, Little, Lorraine, MBioethics, Haddad, Samir, MD, Presneill, Jeffrey, PhD, Arabi, Yaseen, MD, Bailey, Michael, PhD, Cooper, D James, Prof, Duranteau, Jacques, Prof, Huet, Olivier, Prof, Mak, Anne, BScPharm, McArthur, Colin, MBChB, Pettilä, Ville, Prof, Skrifvars, Markus, PhD, Vallance, Shirley, MPH, Varma, Dinesh, MBBS, Wills, Judy, DMU, Bellomo, Rinaldo, Prof

“…Summary Background Erythropoietin might have neurocytoprotective effects. In this trial, we studied its effect on neurological recovery, mortality, and venous…”
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Platform trials for anaesthesia and perioperative medicine: a narrative review by Myles, Paul S, Yeung, Joyce, Beattie, W Scott, Ryan, Elizabeth G, Heritier, Stephane, McArthur, Colin J

“…Large randomised trials provide the most reliable evidence of effectiveness of new treatments in clinical practice. However, the time and resources required to…”
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Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units by Finfer, Simon, Liu, Bette, Taylor, Colman, Bellomo, Rinaldo, Billot, Laurent, Cook, Deborah, Du, Bin, McArthur, Colin, Myburgh, John

“…Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients. We conducted a cross-sectional study…”
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Comparative effectiveness of albumin versus no albumin on renal replacement therapy and mortality in patients with septic shock and renal impairment by Patanwala, Asad E, Flannery, Alexander H, Mehta, Hemalkumar B, Hills, Thomas E, McArthur, Colin J, Erstad, Brian L

“…Albumin infusions may be renally protective or harmful in patients with septic shock who have kidney impairment. This can affect the need for renal replacement…”
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Comparative Effectiveness of Baricitinib Versus Tocilizumab in Hospitalized Patients With COVID-19: A Retrospective Cohort Study of the National Covid Collaborative by Patanwala, Asad E, Xiao, Xuya, Hills, Thomas E, Higgins, Alisa M, McArthur, Colin J, Alexander, G Caleb, Mehta, Hemalkumar B

“…COVID-19 treatment guidelines recommend baricitinib or tocilizumab for the management of hospitalized patients with COVID-19. We compared the effectiveness of…”
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The Effect of a Liberal Approach to Glucose Control in Critically Ill Patients with Type 2 Diabetes: A multicenter, parallel-group, open-label, randomized clinical trial by Poole, Alexis P, Finnis, Mark E, Anstey, James, Bellomo, Rinaldo, Bihari, Shailesh, Birardar, Vishwanath, Doherty, Sarah, Eastwood, Glenn, Finfer, Simon, French, Craig J, Heller, Simon, Horowitz, Michael, Kar, Palash, Kruger, Peter S, Maiden, Matthew J, Mårtensson, Johan, McArthur, Colin J, McGuinness, Shay P, Secombe, Paul J, Tobin, Antony E, Udy, Andrew A, Young, Paul J, Deane, Adam M

“…Rationale Blood glucose concentrations affect outcomes in critically ill patients but the optimal target blood glucose range in those with type 2 diabetes is…”
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Sedation Intensity in the First 48 Hours of Mechanical Ventilation and 180-Day Mortality: A Multinational Prospective Longitudinal Cohort Study by Shehabi, Yahya, Bellomo, Rinaldo, Kadiman, Suhaini, Ti, Lian Kah, Howe, Belinda, Reade, Michael C., Khoo, Tien Meng, Alias, Anita, Wong, Yu-Lin, Mukhopadhyay, Amartya, McArthur, Colin, Seppelt, Ian, Webb, Steven A., Green, Maja, Bailey, Michael J.

“…OBJECTIVES:In the absence of a universal definition of light or deep sedation, the level of sedation that conveys favorable outcomes is unknown. We quantified…”
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Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial by Collins, Michael G, Fahim, Magid A, Pascoe, Elaine M, Hawley, Carmel M, Johnson, David W, Varghese, Julie, Hickey, Laura E, Clayton, Philip A, Dansie, Kathryn B, McConnochie, Rachael C, Vergara, Liza A, Kiriwandeniya, Charani, Reidlinger, Donna, Mount, Peter F, Weinberg, Laurence, McArthur, Colin J, Coates, P Toby, Endre, Zoltan H, Goodman, David, Howard, Kirsten, Howell, Martin, Jamboti, Jagadish S, Kanellis, John, Laurence, Jerome M, Lim, Wai H, McTaggart, Steven J, O'Connell, Philip J, Pilmore, Helen L, Wong, Germaine, Chadban, Steven J, Chadban, Steven J, Ying, Tracey, Gracey, David, Aouad, Leyla, Wyburn, Kate, Habijanec, Beatriz, Yeo, Hee-eun (Ellen), Lin, Lin, Rosales, Brenda, Hudaly, Julia, Rodrigues, Vera, Wong, Germaine, O'Connell, Philip, Murie, Penelope, Endre, Zoltan, Gray, Zuzana, Spicer, Rebecca, Durkan, Anne, Fahim, Magid A, Jegatheesan, Dev, Leary, Diana, Guo, Yujing (Sarah), Coburn, Amanda, Irvine, Rachael, McTaggart, Steven, Crawford, Aimee, Coates, P Toby, Hockley, Bronwyn, Fischer, Karen, Weinberg, Laurence, Mount, Peter, Baulch, Sarah, Claxton, Gayle, Harris, Saskia, Sidiropoulos, Sofia, Veenendal, Marieke, Kanellis, John, Barbis, Rita, Goodman, David, Brahmbhatt, Anjalee, Le Page, Amelia, Jamboti, Jagadish, Chiam, Anna, Warger, Anne, Lim, Wai H, Collins, Michael, Pilmore, Helen, Dittmer, Ian, Manley, Paul, Ahmed, Jafar, McConnochie, Rachael, Newby, Lynette, Chen, Yan, Simmonds, Catherine, Irvine, John, Usher, Jenny, Clark, Carolyn, Beckett, Claire, Prestidge, Chanel, Erickson, Robin, Rea, Miriam, Scherring, Claire

“…Delayed graft function (DGF) is a major adverse complication of deceased donor kidney transplantation. Intravenous fluids are routinely given to patients…”
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Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials by Adhikari, Neill K. J, Hashmi, Madiha, Tirupakuzhi Vijayaraghavan, Bharath Kumar, Haniffa, Rashan, Beane, Abi, Webb, Steve A, Angus, Derek C, Gordon, Anthony C, Cook, Deborah J, Guyatt, Gordon H, Berry, Lindsay R, Lorenzi, Elizabeth, Mouncey, Paul R, Au, Carly, Pinto, Ruxandra, Ménard, Julie, Sprague, Sheila, Masse, Marie-Hélène, Huang, David T, Heyland, Daren K, Nichol, Alistair D, McArthur, Colin J, de Man, Angelique, Al-Beidh, Farah, Annane, Djillali, Anstey, Matthew, Arabi, Yaseen M, Battista, Marie-Claude, Berry, Scott, Bhimani, Zahra, Bonten, Marc J. M, Bradbury, Charlotte A, Brant, Emily B, Brunkhorst, Frank M, Burrell, Aidan, Buxton, Meredith, Cecconi, Maurizio, Cheng, Allen C, Cohen, Dian, Cove, Matthew E, Day, Andrew G, Derde, Lennie P. G, Detry, Michelle A, Estcourt, Lise J, Fagbodun, Elizabeth O, Fitzgerald, Mark, Goossens, Herman, Green, Cameron, Higgins, Alisa M, Hills, Thomas E, Horvat, Christopher, Ichihara, Nao, Jayakumar, Devachandran, Kanji, Salmaan, Khoso, Muhammad Nasir, Lawler, Patrick R, Lewis, Roger J, Litton, Edward, Marshall, John C, McAuley, Daniel F, McGlothlin, Anna, McGuinness, Shay P, McQuilten, Zoe K, McVerry, Bryan J, Murthy, Srinivas, Parke, Rachael L, Parker, Jane C, Reyes, Luis Felipe, Rowan, Kathryn M, Saito, Hiroki, Salahuddin, Nawal, Santos, Marlene S, Saunders, Christina T, Seymour, Christopher W, Shankar-Hari, Manu, Tolppa, Timo, Trapani, Tony, Turgeon, Alexis F, Turner, Anne M, Udy, Andrew A, van de Veerdonk, Frank L, Zarychanski, Ryan, Lamontagne, François

“…IMPORTANCE: The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain. OBJECTIVE: To determine whether vitamin C improves outcomes for…”
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Simvastatin in Critically Ill Patients with Covid-19 by Hills, Thomas E, Lorenzi, Elizabeth, Berry, Lindsay R, Shyamsundar, Murali, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen, Aryal, Diptesh, Au, Carly, Beane, Abigail, Bhimani, Zahra, Bonten, Marc, Bradbury, Charlotte A, Brunkhorst, Frank M, Burrell, Aidan, Buxton, Meredith, Calfee, Carolyn S, Cecconi, Maurizio, Cheng, Allen C, Cove, Matthew E, Detry, Michelle A, Estcourt, Lise J, Fitzgerald, Mark, Goligher, Ewan C, Goossens, Herman, Green, Cameron, Haniffa, Rashan, Harrison, David A, Hashmi, Madiha, Higgins, Alisa M, Huang, David T, Ichihara, Nao, Jayakumar, Deva, Kruger, Peter S, Lamontagne, François, Lampro, Lamprini, Lawler, Patrick R, Marshall, John C, Mason, Alexina J, McGlothlin, Anna, McGuinness, Shay, McQuilten, Zoe K, McVerry, Bryan J, Mouncey, Paul R, Murthy, Srinivas, Neal, Matthew D, Nichol, Alistair D, O'Kane, Cecilia M, Parke, Rachael L, Parker, Jane C, Rabindrarajan, Ebenezer, Reyes, Luis F, Rowan, Kathryn M, Saito, Hiroki, Santos, Marlene, Saunders, Christina T, Seymour, Christopher W, Shankar-Hari, Manu, Sinha, Pratik, Thompson, B Taylor, Turgeon, Alexis F, Turner, Anne M, van de Veerdonk, Frank, Weis, Sebastian, Young, Ian S, Zarychanski, Ryan, Lewis, Roger J, McArthur, Colin J, Angus, Derek C, Berry, Scott M, Derde, Lennie P G, Webb, Steve A, Gordon, Anthony C, McAuley, Daniel F

“…In this trial of simvastatin involving critically ill patients with Covid-19, which was stopped owing to reduced cases, simvastatin did not meet the…”
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