Search Results - "McArdle, A"
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Biomaterials for Craniofacial Bone Engineering
Published in Journal of Dental Research (01-12-2014)“…Conditions such as congenital anomalies, cancers, and trauma can all result in devastating deficits of bone in the craniofacial skeleton. This can lead to…”
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2
Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential
Published in Stem Cells International (01-01-2015)“…Human skin is a remarkable organ that sustains insult and injury throughout life. The ability of skin to expeditiously repair wounds is paramount to survival…”
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3
Ketamine modulates hippocampal neurochemistry and functional connectivity: a combined magnetic resonance spectroscopy and resting-state fMRI study in healthy volunteers
Published in Molecular psychiatry (01-04-2017)“…A growing body of evidence suggests glutamate excess in schizophrenia and that N -methyl- d -aspartate receptor (NMDAR) hypofunction on γ-aminobutyric acid…”
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4
Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders
Published in The Journal of clinical investigation (01-12-2020)“…BACKGROUNDKisspeptin is a key regulator of hypothalamic gonadotropin-releasing hormone (GnRH) neurons and is essential for reproductive health. A specific…”
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Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies
Published in Frontiers in endocrinology (Lausanne) (2013)“…Obesity and associated chronic inflammation initiate a state of insulin resistance (IR). The secretion of chemoattractants such as MCP-1 and MIF and of…”
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6
Information transfer by leaky, heterogeneous, protein kinase signaling systems
Published in Proceedings of the National Academy of Sciences - PNAS (21-01-2014)“…Cells must sense extracellular signals and transfer the information contained about their environment reliably to make appropriate decisions. To perform these…”
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7
Atrioventricular Block as the Initial Manifestation of Cardiac Sarcoidosis in Middle-Aged Adults
Published in Journal of cardiovascular electrophysiology (01-08-2014)“…Cardiac Sarcoidosis Presenting as Atrioventricular Block Introduction Atrioventricular block (AVB) can be caused by several conditions, including cardiac…”
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8
Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader
Published in Nature communications (20-02-2019)“…Normal reproductive functioning is critically dependent on pulsatile secretion of luteinising hormone (LH). Assessment of LH pulsatility is important for the…”
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Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide
Published in Free radical biology & medicine (01-01-2015)“…Reactive oxygen and nitrogen species have been implicated in the loss of skeletal muscle mass and function that occurs during aging. Nitric oxide (NO) and…”
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10
Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function
Published in Cell metabolism (06-10-2010)“…Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is characterized by albuminuria and abnormal glomerular function and is…”
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Digital process control of multi-step assays on centrifugal platforms using high-low-high rotational-pulse triggered valving
Published in PloS one (08-09-2023)“…Due to their capability for comprehensive sample-to-answer automation, the interest in centrifugal microfluidic systems has greatly increased in industry and…”
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Gonadotropin-releasing hormone receptor signaling: biased and unbiased
Published in Mini reviews in medicinal chemistry (01-08-2012)“…Gonadotropin-releasing hormone is a neuropeptide that acts via Gq coupled G-protein coupled receptors in the pituitary that mediate central control of…”
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13
Agonist-induced internalization and desensitization of the apelin receptor
Published in Molecular and cellular endocrinology (05-12-2016)“…Apelin acts via the G protein-coupled apelin receptor (APJ) to mediate effects on cardiovascular and fluid homeostasis. G protein-coupled receptor (GPCR)…”
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14
Pharmacological and Genetic Disruption of C-Type Natriuretic Peptide (nppcl) Expression in Zebrafish (Danio rerio) Causes Stunted Growth during Development
Published in International journal of molecular sciences (18-08-2023)“…Human patients with mutations within NPPC or NPR2 genes (encoding C-type natriuretic peptide (CNP) and guanylyl cyclase-B (GC-B), respectively) display…”
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15
Meta-analysis of complication rates of the tubularized incised plate (TIP) repair
Published in Journal of pediatric urology (01-04-2015)“…Summary Objective To determine overall complication rates of the tubularized incised plate (TIP) repair and assess the effects of technical modifications,…”
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16
HyPer2 imaging reveals temporal and heterogeneous hydrogen peroxide changes in denervated and aged skeletal muscle fibers in vivo
Published in Scientific reports (08-10-2019)“…To determine the role of denervation and motor unit turnover in the age-related increase in skeletal muscle oxidative stress, the hydrogen peroxide (H 2 O 2 )…”
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Lifelong training preserves some redox-regulated adaptive responses after an acute exercise stimulus in aged human skeletal muscle
Published in Free radical biology & medicine (01-05-2014)“…Several redox-regulated responses to an acute exercise bout fail in aged animal skeletal muscle, including the ability to upregulate the expression of…”
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An assessment of psychological distress and professional burnout in mental health professionals in Australia during the COVID-19 pandemic
Published in Australasian psychiatry : bulletin of the Royal Australian and New Zealand College of Psychiatrists (01-12-2021)“…Objective: To examine psychological distress and professional burnout in a cohort of Australian mental healthcare workers during the COVID-19 pandemic Methods:…”
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A role for NPY-NPY2R signaling in albuminuric kidney disease
Published in Proceedings of the National Academy of Sciences - PNAS (07-07-2020)“…Albuminuria is an independent risk factor for the progression to end-stage kidney failure, cardiovascular morbidity, and premature death. As such, discovering…”
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Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing
Published in Skeletal muscle (29-01-2022)“…Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The efficiency of this process declines with age contributing…”
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