Search Results - "McAndrews, Kathleen M."

The role of extracellular vesicles in cancer by Kalluri, Raghu, McAndrews, Kathleen M.

“…Intercellular communication is a key feature of cancer progression and metastasis. Extracellular vesicles (EVs) are generated by all cells, including cancer…”
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Clinical and therapeutic relevance of cancer-associated fibroblasts by Chen, Yang, McAndrews, Kathleen M., Kalluri, Raghu

“…Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly versatile, plastic and resilient cells that are actively involved in…”
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Mechanisms associated with biogenesis of exosomes in cancer by McAndrews, Kathleen M, Kalluri, Raghu

“…Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer…”
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Enacting national social distancing policies corresponds with dramatic reduction in COVID19 infection rates by McGrail, Daniel J, Dai, Jianli, McAndrews, Kathleen M, Kalluri, Raghu

“…The outbreak the SARS-CoV-2 (CoV-2) virus has resulted in over 6.5 million cases of COVID19, greatly stressing global healthcare infrastructure. Lacking…”
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Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer by Chen, Yang, Yang, Sujuan, Tavormina, Jena, Tampe, Desiree, Zeisberg, Michael, Wang, Huamin, Mahadevan, Krishnan K., Wu, Chang-Jiun, Sugimoto, Hikaru, Chang, Chia-Chi, Jenq, Robert R., McAndrews, Kathleen M., Kalluri, Raghu

“…In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts, pancreatic cancer cells specifically produce unique Col1…”
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Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer by Becker, Lisa M., O’Connell, Joyce T., Vo, Annie P., Cain, Margo P., Tampe, Desiree, Bizarro, Lauren, Sugimoto, Hikaru, McGow, Anna K., Asara, John M., Lovisa, Sara, McAndrews, Kathleen M., Zielinski, Rafal, Lorenzi, Philip L., Zeisberg, Michael, Raza, Sughra, LeBleu, Valerie S., Kalluri, Raghu

“…The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer progression remain to be fully understood. While altered glucose…”
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Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta by Chen, Yang, Yang, Sujuan, Lovisa, Sara, Ambrose, Catherine G., McAndrews, Kathleen M., Sugimoto, Hikaru, Kalluri, Raghu

“…Type I collagen (Col1) is the most abundant protein in mammals. Col1 contributes to 90% of the total organic component of bone matrix. However, the precise…”
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Generation and testing of clinical-grade exosomes for pancreatic cancer by Mendt, Mayela, Kamerkar, Sushrut, Sugimoto, Hikaru, McAndrews, Kathleen M, Wu, Chia-Chin, Gagea, Mihai, Yang, Sujuan, Blanko, Elena V Rodriges, Peng, Qian, Ma, Xiaoyan, Marszalek, Joseph R, Maitra, Anirban, Yee, Cassian, Rezvani, Katayoun, Shpall, Elizabeth, LeBleu, Valerie S, Kalluri, Raghu

“…Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded…”
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Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer by Carstens, Julienne L., Yang, Sujuan, Correa de Sampaio, Pedro, Zheng, Xiaofeng, Barua, Souptik, McAndrews, Kathleen M., Rao, Arvind, Burks, Jared K., Rhim, Andrew D., Kalluri, Raghu

“…Pancreatic ductal adenocarcinoma (PDAC) is therapeutically recalcitrant and metastatic. Partial epithelial to mesenchymal transition (EMT) is associated with…”
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Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity by McAndrews, Kathleen M, Dowlatshahi, Dara P, Dai, Jianli, Becker, Lisa M, Hensel, Janine, Snowden, Laura M, Leveille, Jennifer M, Brunner, Michael R, Holden, Kylie W, Hopkins, Nikolas S, Harris, Alexandria M, Kumpati, Jerusha, Whitt, Michael A, Lee, J Jack, Ostrosky-Zeichner, Luis L, Papanna, Ramesha, LeBleu, Valerie S, Allison, James P, Kalluri, Raghu

“…Evaluation of potential immunity against the novel severe acute respiratory syndrome (SARS) coronavirus that emerged in 2019 (SARS-CoV-2) is essential for…”
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Osmotic Regulation Is Required for Cancer Cell Survival under Solid Stress by McGrail, Daniel J., McAndrews, Kathleen M., Brandenburg, Chandler P., Ravikumar, Nithin, Kieu, Quang Minh N., Dawson, Michelle R.

“…For a solid tumor to grow, it must be able to support the compressive stress that is generated as it presses against the surrounding tissue. Although the…”
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Biomechanical analysis predicts decreased human mesenchymal stem cell function before molecular differences by McGrail, Daniel J., McAndrews, Kathleen M., Dawson, Michelle R.

“…Multipotent human mesenchymal stem cells (hMSCs) are uniquely suited for the growing field of regenerative medicine due to their ease of isolation, expansion,…”
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Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells by Don-Salu-Hewage, Ayesha S, Chan, Siu Yuen, McAndrews, Kathleen M, Chetram, Mahandranauth A, Dawson, Michelle R, Bethea, Danaya A, Hinton, Cimona V

“…The G-protein coupled receptor (GPCR), Cysteine (C)-X-C Receptor 4 (CXCR4), plays an important role in prostate cancer metastasis. CXCR4 is generally regarded…”
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High throughput and rapid isolation of extracellular vesicles and exosomes with purity using size exclusion liquid chromatography by Kapoor, Kshipra S., Harris, Kristen, Arian, Kent A., Ma, Lihua, Schueng Zancanela, Beatriz, Church, Kaira A., McAndrews, Kathleen M., Kalluri, Raghu

“…Extracellular vesicles (EVs) have emerged as potential biomarkers for diagnosing a range of diseases without invasive procedures. Extracellular vesicles also…”
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Enhanced Adhesion of Stromal Cells to Invasive Cancer Cells Regulated by Cadherin 11 by McAndrews, Kathleen M, Yi, Jaeyoon, McGrail, Daniel J, Dawson, Michelle R

“…Cancer-associated fibroblasts (CAFs) are known to promote tumor growth and metastasis; however their differential accumulation in invasive and noninvasive…”
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Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker by Kugeratski, Fernanda G., Hodge, Kelly, Lilla, Sergio, McAndrews, Kathleen M., Zhou, Xunian, Hwang, Rosa F., Zanivan, Sara, Kalluri, Raghu

“…Exosomes are extracellular vesicles derived from the endosomal compartment that are potentially involved in intercellular communication. Here, we found that…”
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Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer by Zhou, Xunian, Kurywchak, Paul, Wolf-Dennen, Kerri, Che, Sara P.Y., Sulakhe, Dinanath, D’Souza, Mark, Xie, Bingqing, Maltsev, Natalia, Gilliam, T. Conrad, Wu, Chia-Chin, McAndrews, Kathleen M., LeBleu, Valerie S., McConkey, David J., Volpert, Olga V., Pretzsch, Shanna M., Czerniak, Bogdan A., Dinney, Colin P., Kalluri, Raghu

“…Bladder cancer (BC), a heterogeneous disease characterized by high recurrence rates, is diagnosed and monitored by cystoscopy. Accurate clinical staging based…”
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Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis by Tang, Min, Chen, Yang, Li, Bingrui, Sugimoto, Hikaru, Yang, Sujuan, Yang, Changqing, LeBleu, Valerie S., McAndrews, Kathleen M., Kalluri, Raghu

“…Hepatic fibrosis is a wound healing response that results in excessive extracellular matrix (ECM) accumulation in response to chronic hepatic injury. Signal…”
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Stromal Cells Exhibit Prevalent Genetic Aberrations in Colorectal Cancer by McAndrews, Kathleen M., Chen, Yang, Kalluri, Raghu

“…Cells within the tumor microenvironment can influence tumor progression; however, genetic alterations in stromal cell populations remain largely unexplored. In…”
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Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer by Kugeratski, Fernanda G, McAndrews, Kathleen M, Kalluri, Raghu

“…Abstract Extracellular vesicles (EVs) are key players of intercellular communication in the physiological and pathological setting. In cancer, EVs mediate…”
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