Search Results - "McAinsh, Andrew D"

Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles by Drechsler, Hauke, McAinsh, Andrew D.

“…Human Kinesin-12 (hKif15) plays a crucial role in assembly and maintenance of the mitotic spindle. These functions of hKif15 are partially redundant with…”
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KNL1-Bubs and RZZ Provide Two Separable Pathways for Checkpoint Activation at Human Kinetochores by Silió, Virginia, McAinsh, Andrew D., Millar, Jonathan B.

“…The spindle assembly checkpoint (SAC) ensures the accurate segregation of sister chromatids during mitosis. Activation of the SAC occurs through a series of…”
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The first mitotic division of human embryos is highly error prone by Currie, Cerys E., Ford, Emma, Benham Whyte, Lucy, Taylor, Deborah M., Mihalas, Bettina P., Erent, Muriel, Marston, Adele L., Hartshorne, Geraldine M., McAinsh, Andrew D.

“…Human beings are made of ~50 trillion cells which arise from serial mitotic divisions of a single cell - the fertilised egg. Remarkably, the early human embryo…”
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Building an integrated model of chromosome congression by Auckland, Philip, McAinsh, Andrew D

“…A universal feature of mitosis is that all chromosomes become aligned at the spindle equator--the halfway point between the two spindle poles--prior to…”
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CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes by Auckland, Philip, Roscioli, Emanuele, Coker, Helena Louise Elvidge, McAinsh, Andrew D

“…Accurate chromosome segregation demands efficient capture of microtubules by kinetochores and their conversion to stable bioriented attachments that can…”
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Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments by Dudka, Damian, Noatynska, Anna, Smith, Chris A., Liaudet, Nicolas, McAinsh, Andrew D., Meraldi, Patrick

“…Kinetochores are multi-protein complexes that power chromosome movements by tracking microtubules plus-ends in the mitotic spindle. Human kinetochores bind up…”
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Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment by Auckland, Philip, Clarke, Nicholas I, Royle, Stephen J, McAinsh, Andrew D

“…Kinetochores mediate chromosome congression by either sliding along the lattice of spindle microtubules or forming end-on attachments to their depolymerizing…”
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Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80 by Pesenti, Marion E., Prumbaum, Daniel, Auckland, Philip, Smith, Charlotte M., Faesen, Alex C., Petrovic, Arsen, Erent, Muriel, Maffini, Stefano, Pentakota, Satyakrishna, Weir, John R., Lin, Yu-Chih, Raunser, Stefan, McAinsh, Andrew D., Musacchio, Andrea

“…The approximately thirty core subunits of kinetochores assemble on centromeric chromatin containing the histone H3 variant CENP-A and connect chromosomes with…”
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Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways by Bancroft, James, Auckland, Philip, Samora, Catarina P, McAinsh, Andrew D

“…A key step of mitosis is the congression of chromosomes to the spindle equator. Congression is driven by at least two distinct mechanisms: (1) kinetochores…”
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Bayesian inference of multi-point macromolecular architecture mixtures at nanometre resolution by Embacher, Peter A, Germanova, Tsvetelina E, Roscioli, Emanuele, McAinsh, Andrew D, Burroughs, Nigel J

“…Gaussian spot fitting methods have significantly extended the spatial range where fluorescent microscopy can be used, with recent techniques approaching…”
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Cdk1 Inactivation Terminates Mitotic Checkpoint Surveillance and Stabilizes Kinetochore Attachments in Anaphase by Vázquez-Novelle, María Dolores, Sansregret, Laurent, Dick, Amalie E., Smith, Christopher A., McAinsh, Andrew D., Gerlich, Daniel W., Petronczki, Mark

“…Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate…”
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Mps1 Regulates Kinetochore-Microtubule Attachment Stability via the Ska Complex to Ensure Error-Free Chromosome Segregation by Maciejowski, John, Drechsler, Hauke, Grundner-Culemann, Kathrin, Ballister, Edward R., Rodriguez-Rodriguez, Jose-Antonio, Rodriguez-Bravo, Veronica, Jones, Mathew J.K., Foley, Emily, Lampson, Michael A., Daub, Henrik, McAinsh, Andrew D., Jallepalli, Prasad V.

“…The spindle assembly checkpoint kinase Mps1 not only inhibits anaphase but also corrects erroneous attachments that could lead to missegregation and…”
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Evidence for a HURP/EB free mixed-nucleotide zone in kinetochore-microtubules by Castrogiovanni, Cédric, Inchingolo, Alessio V., Harrison, Jonathan U., Dudka, Damian, Sen, Onur, Burroughs, Nigel J., McAinsh, Andrew D., Meraldi, Patrick

“…Current models infer that the microtubule-based mitotic spindle is built from GDP-tubulin with small GTP caps at microtubule plus-ends, including those that…”
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MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis by Straube, Anne, McAinsh, Andrew D, Samora, Catarina P, Mogessie, Binyam, Conway, Leslie, Ross, Jennifer L

“…Correct positioning of the mitotic spindle is critical to establish the correct cell-division plane. Spindle positioning involves capture of astral…”
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Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors by Roscioli, Emanuele, Germanova, Tsvetelina E., Smith, Christopher A., Embacher, Peter A., Erent, Muriel, Thompson, Amelia I., Burroughs, Nigel J., McAinsh, Andrew D.

“…Kinetochores are multi-protein machines that form dynamic attachments to microtubules and control chromosome segregation. High fidelity is ensured because…”
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How Kinetochores CCAN resist force by McAinsh, Andrew D

“…Kinetochores orchestrate chromosome segregation during mitosis and must cope with dynamic forces generated by attached microtubules. In this issue of…”
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Kif15 functions as an active mechanical ratchet by McHugh, Toni, Drechsler, Hauke, McAinsh, Andrew D, Carter, Nicolas J, Cross, Robert A

“…Kif15 is a kinesin-12 that contributes critically to bipolar spindle assembly in humans. Here we use force-ramp experiments in an optical trap to probe the…”
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The CCAN complex: Linking centromere specification to control of kinetochore–microtubule dynamics by McAinsh, Andrew D., Meraldi, Patrick

“…For over 70 years, chromosomes have been known to oscillate back-and-forth on the metaphase plate. These movements are directed by kinetochores, the…”
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Nonautonomous Movement of Chromosomes in Mitosis by Vladimirou, Elina, Mchedlishvili, Nunu, Gasic, Ivana, Armond, Jonathan W., Samora, Catarina P., Meraldi, Patrick, McAinsh, Andrew D.

“…Kinetochores are the central force-generating machines that move chromosomes during cell division. It is generally assumed that kinetochores move in an…”
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Molecular control of kinetochore-microtubule dynamics and chromosome oscillations by Alonso, Maria, Wang, Enxiu, Lampson, Michael, Kingston, Isabel J, McAinsh, Andrew D, Meraldi, Patrick, Amaro, Ana C, Holtackers, René, Samora, Catarina P

“…The core kinetochore protein CENP-H is shown to be required for the organization of the metaphase plate. CENP-H regulates microtubule plus-end dynamics, and…”
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