Search Results - "Mbaze, Luc Meva’a"

AfroDb: a select highly potent and diverse natural product library from African medicinal plants by Ntie-Kang, Fidele, Zofou, Denis, Babiaka, Smith B, Meudom, Rolande, Scharfe, Michael, Lifongo, Lydia L, Mbah, James A, Mbaze, Luc Meva'a, Sippl, Wolfgang, Efange, Simon M N

“…Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability of such is vital for drug discovery…”
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B3LYP, M06 and B3PW91 DFT assignment of nd8 metal-bis-(N-heterocyclic carbene) complexes by Moto Ongagna, Jean, Tamafo Fouegue, Aymard Didier, Ateba Amana, Baruch, Mouzong D’ambassa, Gaël, Zobo Mfomo, Joseph, Mbaze Meva’A, Luc, Bikele Mama, Désiré

“…This paper is focused on the examination of the bonding properties of a series of [M(NHC) 2 X 2 ] (M = nd 8 transition metal; X = Cl, Br and I) complexes in…”
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Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae) by Mbaze, Luc Meva’a, Lado, Jean Alexandre, Wansi, Jean Duplex, Shiao, Tze Chieh, Chiozem, David Dako, Mesaik, Muhammad Ahmed, Choudhary, Muhammad Iqbal, Lacaille-Dubois, Marie-Aleth, Wandji, Jean, Roy, René, Sewald, Norbert

“…Two amides, heitziamide A ( 1) and heitziamide B ( 2) and two phenylethanoids, heitziethanoid A ( 3) and heitziethanoid B ( 4) were isolated from the stem bark…”
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α-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae) by Mbaze, Luc Meva’a, Poumale, Herve Martial P., Wansi, Jean Duplex, Lado, Jean Alexandre, Khan, Shamsun Nahar, Iqbal, Muhammad Choudhary, Ngadjui, Bonaventure Tchaleu, Laatsch, Hartmut

“…Two pentacyclic triterpene acetates derivatives were isolated from Fagara tessmannii Engl. Compounds 1 and 3a showed significant inhibition of α-glucosidase…”
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α-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae) by Wansi, Jean Duplex, Lallemand, Marie-Christine, Chiozem, David Daco, Toze, Flavien Aristide A., Mbaze, Luc Meva’a, Naharkhan, Shamsun, Iqbal, Muhammad Choudhary, Tillequin, François, Wandji, Jean, Fomum, Zacharias Tanee

“…The CH 2Cl 2/CH 3OH (1/1) extract of the stem bark of Terminalia superba afforded two compounds, (7 S,8 R,7′ R,8′ S)-4′-hydroxy-4-methoxy-7,7′-epoxylignan 1…”
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The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids by Ntie-Kang, Fidele, Onguéné, Pascal Amoa, Lifongo, Lydia L, Ndom, Jean Claude, Sippl, Wolfgang, Mbaze, Luc Meva'a

“…Malaria is currently a public health concern in many countries in the world due to various factors which are not yet under check. Drug discovery projects…”
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Molecular Modeling of Potential Anticancer Agents from African Medicinal Plants by Ntie-Kang, Fidele, Nwodo, Justina Ngozi, Ibezim, Akachukwu, Simoben, Conrad Veranso, Karaman, Berin, Ngwa, Valery Fuh, Sippl, Wolfgang, Adikwu, Michael Umale, Mbaze, Luc Meva’a

“…Naturally occurring anticancer compounds represent about half of the chemotherapeutic drugs which have been put in the market against cancer until date…”
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Virtualizing the p-ANAPL library: a step towards drug discovery from African medicinal plants by Ntie-Kang, Fidele, Amoa Onguéné, Pascal, Fotso, Ghislain W, Andrae-Marobela, Kerstin, Bezabih, Merhatibeb, Ndom, Jean Claude, Ngadjui, Bonaventure T, Ogundaini, Abiodun O, Abegaz, Berhanu M, Meva'a, Luc Mbaze

“…Natural products play a key role in drug discovery programs, both serving as drugs and as templates for the synthesis of drugs, even though the quantities and…”
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The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids by Amoa Onguéné, Pascal, Ntie-Kang, Fidele, Lifongo, Lydia Likowo, Ndom, Jean Claude, Sippl, Wolfgang, Mbaze, Luc Meva'a

“…Traditional medicine caters for about 80% of the health care needs of many rural populations around the world, especially in developing countries. In addition,…”
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DFT/B3LYP and BP86 examination of mononuclear half-sandwich nd7 metallo drug complexes based on N∩O dendritic scaffolds by Simon Claude, Ndika Ngomb, Didier, Tamafo Fouegue Aymard, Baruch, Ateba Amana, Joseph, Zobo Mfomo, Luc, Mbaze Meva’a, Désiré, Bikele Mama

“…In this paper, we have explored the bonding properties of a series of mononuclear half-sandwich nd7 anticancer complexes based on N∩O dendritic scaffolds (L)…”
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α-Glucosidase Inhibitory and Antioxidant Acridone Alkaloids from the Stem Bark of Oriciopsis glaberrima ENGL. (Rutaceae) by Wansi, Jean Duplex, Wandji, Jean, Meva'a, Luc Mbaze, Waffo, Alain François Kamdem, Ranjit, Rose, Khan, Shamsun Nahar, Asma, Azaz, Iqbal, Choudhary Muhammad, Lallemand, Marie-Christine, Tillequin, François, Tanee, Zacharias Fomum

“…The CH2Cl2/MeOH extract of the stem bark of Oriciopsis glaberrima ENGL. afforded four new acridone alkaloids namely oriciacridone C, D, E and F along with six…”
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Xylatolides A and B, new 10-membered macrolides from the endophytic fungus Xylaria sp by Koliye, Pierre Roger, Nouga Bissoue, Achille, Ngoh Misse Mouelle, Eitel, Kwanga Nguikwie, Sylvie, Zambo Owona, Claudine Victoire, Simons, Viktor Emanuel, Akone, Sergi Herve, Mbaze Meva’a, Luc, Kalscheuer, Rainer

“…Chemical investigation of the fungal endophyte sp. isolated from leaves of , collected in Cameroon, resulted in the previously undescribed 10-membered…”
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Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors by Tietjen, Ian, Ntie-Kang, Fidele, Mwimanzi, Philip, Onguéné, Pascal Amoa, Scull, Margaret A, Idowu, Thomas Oyebode, Ogundaini, Abiodun Oguntuga, Meva'a, Luc Mbaze, Abegaz, Berhanu M, Rice, Charles M, Andrae-Marobela, Kerstin, Brockman, Mark A, Brumme, Zabrina L, Fedida, David

“…The continued burden of HIV in resource-limited regions such as parts of sub-Saharan Africa, combined with adverse effects and potential risks of resistance to…”
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In silico toxicity profiling of natural product compound libraries from African flora with anti-malarial and anti-HIV properties by Onguéné, Pascal Amoa, Simoben, Conrad V., Fotso, Ghislain W., Andrae-Marobela, Kerstin, Khalid, Sami A., Ngadjui, Bonaventure T., Mbaze, Luc Meva’a, Ntie-Kang, Fidele

“…[Display omitted] •The manuscript discusses toxicity predictions for three datasets of naturally occurring metabolites.•One dataset includes about 500…”
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CamMedNP: building the Cameroonian 3D structural natural products database for virtual screening by Ntie-Kang, Fidele, Mbah, James A, Mbaze, Luc Meva'a, Lifongo, Lydia L, Scharfe, Michael, Hanna, Joelle Ngo, Cho-Ngwa, Fidelis, Onguéné, Pascal Amoa, Owono Owono, Luc C, Megnassan, Eugene, Sippl, Wolfgang, Efange, Simon M N

“…Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability of such is vital for drug discovery…”
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Identification of potential dipeptidyl peptidase IV inhibitors from the ConMedNP library by virtual screening, and molecular dynamics methods by Tsahnang Fofack, Hans Merlin, Mbah Bake, Maraf, Petry, Simon, Ateba, Baruch A., Amoa Onguéné, Pascal, Mohammad-Salim, Haydar, Ntie-Kang, Fidele, Mbaze, Luc Meva'a, Vakal, Serhii, Kenfack, Cyril A

“…In this study, we screened novel dipeptidyl peptidase IV (DPP4) inhibitors from the ConMedNP library consisting of 3507 molecules. Interestingly, molecular…”
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Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants by Ntie-Kang, Fidele, Simoben, Conrad Veranso, Karaman, Berin, Ngwa, Valery Fuh, Judson, Philip Neville, Sippl, Wolfgang, Mbaze, Luc Meva'a

“…Molecular modeling has been employed in the search for lead compounds of chemotherapy to fight cancer. In this study, pharmacophore models have been generated…”
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Afzeliixanthones A and B, Two New Prenylated Xanthones from Garcinia afzelii ENGL. (Guttiferae) by Waffo, Alain François Kamdem, Mulholland, Dulcie, Wansi, Jean Duplex, Mbaze, Luc Meva'a, Powo, Robert, Mpondo, Theophile Ngando, Fomum, Zacharias Tanee, König, Wilfried, Nkengfack, Augustin Ephrem

“…Two new prenylated xanthones, afzeliixanthones A (1) and B (2), together with three known xanthones (3—5) and two phytosterols, β-sitosterol and stigmasterol,…”
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Thermodynamics-antioxidant activity relationships of some 4-benzylidenamino-4, 5-dihydro-1h-1,2,4-triazol-5-one derivatives: Theoretical evaluation by Zobo Mfomo, Joseph, Bikele Mama, Désiré, Lissouck, Daniel, Younang, Elie, N'sikabaka, Samuel, Mbouombouo Ndassa, Ibrahim, Mbaze Meva'à, Luc

“…Density functional methods were used to predict the antioxidative efficiency of thirteen 4-benzylidenamino-4, 5-dihydro-1H-1,2,4-triazol-5-one derivatives in…”
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Amides from the stem bark of Fagara macrophylla by Wansi, Jean Duplex, Nwozo, Sarah Onyenibe, Mbaze, Luc Meva'a, Devkota, Krishna Prasad, Donkwe Moladje, Suzye Mireille, Fomum, Zacharias Tanee, Sewald, Norbert

“…Five new amide alkaloids, N-(4-hydroxyphenethyl)octacosanamide (1), N-(4-hydroxyphenethyl)hexacosanamide (2), N-(4-hydroxyphenethyl)decanamide (3),…”
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