Search Results - "Mazzotta, M."

One Actor, Multiple Roles: The Performances of Cryptochrome in Drosophila by Damulewicz, Milena, Mazzotta, Gabriella M

“…Cryptochromes (CRYs) are flavoproteins that are sensitive to blue light, first identified in and then in and mice. They are evolutionarily conserved and play…”
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KEAP1-driven co-mutations in lung adenocarcinoma unresponsive to immunotherapy despite high tumor mutational burden by Marinelli, D., Mazzotta, M., Scalera, S., Terrenato, I., Sperati, F., D'Ambrosio, L., Pallocca, M., Corleone, G., Krasniqi, E., Pizzuti, L., Barba, M., Carpano, S., Vici, P., Filetti, M., Giusti, R., Vecchione, A., Occhipinti, M., Gelibter, A., Botticelli, A., De Nicola, F., Ciuffreda, L., Goeman, F., Gallo, E., Visca, P., Pescarmona, E., Fanciulli, M., De Maria, R., Marchetti, P., Ciliberto, G., Maugeri-Saccà, M.

“…Immune checkpoint inhibitors (ICIs) have demonstrated significant overall survival (OS) benefit in lung adenocarcinoma (LUAD). Nevertheless, a remarkable…”
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Immunotherapy in HER2-positive breast cancer: state of the art and future perspectives by Krasniqi, E, Barchiesi, G, Pizzuti, L, Mazzotta, M, Venuti, A, Maugeri-Saccà, M, Sanguineti, G, Massimiani, G, Sergi, D, Carpano, S, Marchetti, P, Tomao, S, Gamucci, T, De Maria, R, Tomao, F, Natoli, C, Tinari, N, Ciliberto, G, Barba, M, Vici, P

“…Breast cancer (BC) is a complex disease with primary or acquired incurability characteristics in a significant part of patients. Immunotherapeutical agents…”
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Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster by Cusumano, Paola, Biscontin, Alberto, Sandrelli, Federica, Mazzotta, Gabriella M, Tregnago, Claudia, De Pittà, Cristiano, Costa, Rodolfo

“…Single microRNAs are usually associated with hundreds of putative target genes that can influence multiple phenotypic traits in Drosophila, ranging from…”
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Effects of active cancer treatment on safety and immunogenicity of COVID-19 mRNA-BNT162b2 vaccine: preliminary results from the prospective observational Vax-On study by Nelli, F., Fabbri, A., Onorato, A., Giannarelli, D., Silvestri, M.A., Giron Berrios, J.R., Virtuoso, A., Marrucci, E., Signorelli, C., Chilelli, M.G., Primi, F., Schirripa, M., Mazzotta, M., Ruggeri, E.M.

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Alpha Synuclein Toxicity and Non-Motor Parkinson's by Mazzotta, Gabriella M, Conte, Carmela

“…Parkinson's disease (PD) is a common multisystem neurodegenerative disorder affecting 1% of the population over the age of 60 years. The main neuropathological…”
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Non-monetary valuation using Multi-Criteria Decision Analysis: Sensitivity of additive aggregation methods to scaling and compensation assumptions by Martin, D.M., Mazzotta, M.

“…•MCDA supports the non-monetary valuation of ecosystem services.•Additive aggregation methods have important scaling and compensation assumptions.•Results are…”
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Set-theoretical solutions of the pentagon equation on groups by Catino, F., Mazzotta, M., Miccoli, M. M.

“…Let M be a set. A set-theoretical solution of the pentagon equation on M is a map such that where and and τ is the flip map, i.e., the permutation on M × M…”
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Synucleinopathies Take Their Toll: Are TLRs a Way to Go? by Mazzotta, Gabriella M, Ceccato, Nadia, Conte, Carmela

“…The misfolding and subsequent abnormal accumulation and aggregation of α-Synuclein (αSyn) as insoluble fibrils in Lewy bodies and Lewy neurites is the…”
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Better Sleep at Night: How Light Influences Sleep in Drosophila by Mazzotta, Gabriella M, Damulewicz, Milena, Cusumano, Paola

“…Sleep-like states have been described in and the mechanisms and factors that generate and define sleep-wake profiles in this model organism are being…”
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Usp14 down-regulation corrects sleep and circadian dysfunction of a Drosophila model of Parkinson's disease by Favaro, Mariavittoria, Mauri, Sofia, Bernardo, Greta, Zordan, Mauro A, Mazzotta, Gabriella M, Ziviani, Elena

“…PD is a complex, multifactorial neurodegenerative disease, which occurs sporadically in aged population, with some genetically linked cases. Patients develop a…”
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Corrigendum: One Actor, Multiple Roles: The Performances of Cryptochrome in Drosophila by Damulewicz, Milena, Mazzotta, Gabriella M.

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MicroRNA expression profiling of oral carcinoma identifies new markers of tumor progression by Scapoli, L, Palmieri, A, Lo Muzio, L, Pezzetti, F, Rubini, C, Girardi, A, Farinella, F, Mazzotta, M, Carinci, F

“…Oral squamous cell carcinoma, the most frequently occurring malignant head and neck tumour, generally exhibits poor prognosis and metastases are the main cause…”
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Malignant Chondroid Syringoma of the Face With Distant Metastasis by Miranda, J A, Mazzotta, M M, Zalazar, É V

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Spatial multi-criteria analysis based on food web model results: application to a marine conservation area by Donati, E., Ponti, M., Turicchia, E., Airoldi, L., Mazzotta, M., Bernardi, J., Calì, F., Mazzoldi, C., Russo, E., Pranovi, F., Fabbri, F., Brigolin, D.

“…•Spatialised food web model allowed to derive multiple ecosystem indicators.•Spatial multi-criteria analysis allowed synthesising indicators into a final…”
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Mitochondrial autophagy in the sleeping brain by Mauri, Sofia, Favaro, Mariavittoria, Bernardo, Greta, Mazzotta, Gabriella M., Ziviani, Elena

“…A significant percentage of the mitochondrial mass is replaced on a daily basis via mechanisms of mitochondrial quality control. Through mitophagy (a selective…”
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AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis by Guo, Deliang, Hildebrandt, Isabel J, Prins, Robert M, Soto, Horacio, Mazzotta, Mary M, Dang, Julie, Czernin, Johannes, Shyy, John Y.-J, Watson, Andrew D, Phelps, Michael, Radu, Caius G, Cloughesy, Timothy F, Mischel, Paul S

“…The EGFR/PI3K/Akt/mTOR signaling pathway is activated in many cancers including glioblastoma, yet mTOR inhibitors have largely failed to show efficacy in the…”
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Clonal KEAP1 mutations with loss of heterozygosity share reduced immunotherapy efficacy and low immune cell infiltration in lung adenocarcinoma by Scalera, S., Ricciuti, B., Mazzotta, M., Calonaci, N., Alessi, J.V., Cipriani, L., Bon, G., Messina, B., Lamberti, G., Di Federico, A., Pecci, F., Milite, S., Krasniqi, E., Barba, M., Vici, P., Vecchione, A., De Nicola, F., Ciuffreda, L., Goeman, F., Fanciulli, M., Buglioni, S., Pescarmona, E., Sharma, B., Felt, K.D., Lindsay, J., Rodig, S.J., De Maria, R., Caravagna, G., Cappuzzo, F., Ciliberto, G., Awad, M.M., Maugeri-Saccà, M.

“…KEAP1 mutations have been associated with reduced survival in lung adenocarcinoma (LUAD) patients treated with immune checkpoint inhibitors (ICIs),…”
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Immunogenicity and early clinical outcome after two or three doses of SARS-CoV-2 mRNA-BNT162b2 vaccine in actively treated cancer patients: results from the prospective observational Vax-On-Third study by Nelli, F., Giannarelli, D., Fabbri, A., Silvestri, M.A., Berrios, J. R. Giron, Virtuoso, A., Marrucci, E., Schirripa, M., Mazzotta, M., Onorato, A., Panichi, V., Topini, G., Pessina, G., Natoni, F., Signorelli, C., Chilelli, M.G., Primi, F., Ruggeri, E.M.

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New Drosophila Circadian Clock Mutants Affecting Temperature Compensation Induced by Targeted Mutagenesis of Timeless by Singh, Samarjeet, Giesecke, Astrid, Damulewicz, Milena, Fexova, Silvie, Mazzotta, Gabriella M, Stanewsky, Ralf, Dolezel, David

“…has served as an excellent genetic model to decipher the molecular basis of the circadian clock. Two key proteins, PERIOD (PER) and TIMELESS (TIM), are…”
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