Search Results - "Mazzoni, Maria R"

Pharmacological intervention at CCR1 and CCR5 as an approach for cancer: help or hindrance by Karash, Angela, Mazzoni, Maria R, Gilchrist, Annette

“…While a number of agents directed at chemokine receptors have entered clinic trials, the vast majority of these have failed, and the enthusiasm for this class…”
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The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved by Giusti, Laura, Tesi, Marta, Ciregia, Federica, Marselli, Lorella, Zallocco, Lorenzo, Suleiman, Mara, De Luca, Carmela, Del Guerra, Silvia, Zuccarini, Mariachiara, Trerotola, Marco, Eizirik, Decio L, Cnop, Miriam, Mazzoni, Maria R, Marchetti, Piero, Lucacchini, Antonio, Ronci, Maurizio

“…Metformin, a drug widely used in type 2 diabetes (T2D), has been shown to protect human β-cells exposed to gluco- and/or lipotoxic conditions and those in…”
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Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors by Nencetti, Susanna, Mazzoni, Maria R., Ortore, Gabriella, Lapucci, Annalina, Giuntini, Janette, Orlandini, Elisabetta, Banti, Irene, Nuti, Elisa, Lucacchini, Antonio, Giannaccini, Gino, Rossello, Armando

“…With the aim of obtaining compounds possessing high SERT selectivity, in the present work we synthesized and studied the inhibition of serotonin (SERT),…”
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Thrombin Modulates the Expression of a Set of Genes Including Thrombospondin-1 in Human Microvascular Endothelial Cells by McLaughlin, Joseph N., Mazzoni, Maria R., Cleator, John H., Earls, Laurie, Perdigoto, Ana Luisa, Brooks, Joshua D., Muldowney, James A.S., Vaughan, Douglas E., Hamm, Heidi E.

“…Thrombospondin-1 (THBS1) is a large extracellular matrix glycoprotein that affects vasculature systems such as platelet activation, angiogenesis, and wound…”
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Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets by Ciregia, Federica, Bugliani, Marco, Ronci, Maurizio, Giusti, Laura, Boldrini, Claudia, Mazzoni, Maria R, Mossuto, Sandra, Grano, Francesca, Cnop, Miriam, Marselli, Lorella, Giannaccini, Gino, Urbani, Andrea, Lucacchini, Antonio, Marchetti, Piero

“…Type 2 diabetes is characterized by progressive β cell dysfunction, with lipotoxicity playing a possible pathogenetic role. Palmitate is often used to examine…”
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Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype by Giusti, Laura, Ciregia, Federica, Bonotti, Alessandra, Da Valle, Ylenia, Donadio, Elena, Boldrini, Claudia, Foddis, Rudy, Giannaccini, Gino, Mazzoni, Maria R., Canessa, Pier Aldo, Cristaudo, Alfonso, Lucacchini, Antonio

“…[Display omitted] ⿢We performed a comparative proteomic analysis of biphasic pleural mesothelioma (BPM) by 2D/MS approach.⿢Twenty-two proteins were found…”
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Putative salivary biomarkers useful to differentiate patients with fibromyalgia by Ciregia, Federica, Giacomelli, Camillo, Giusti, Laura, Boldrini, Claudia, Piga, Isabella, Pepe, Pasquale, Consensi, Arianna, Gori, Sara, Lucacchini, Antonio, Mazzoni, Maria R., Bazzichi, Laura

“…Fibromyalgia (FM) is a chronic pain disorder characterized by widespread pain and associated with unspecific symptoms. So far, no laboratory tests have been…”
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Proteomic analysis of fine-needle aspiration in differential diagnosis of thyroid nodules by Ciregia, Federica, Giusti, Laura, Molinaro, Angelo, Niccolai, Filippo, Mazzoni, Maria R, Rago, Teresa, Tonacchera, Massimo, Vitti, Paolo, Giannaccini, Gino, Lucacchini, Antonio

“…Thyroid nodules are common in the general population and vary widely in their propensity to harbor thyroid malignancies. The category of follicular lesion of…”
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Insights into G Protein Structure, Function, and Regulation by Cabrera-Vera, Theresa M, Vanhauwe, Jurgen, Thomas, Tarita O, Medkova, Martina, Preininger, Anita, Mazzoni, Maria R, Hamm, Heidi E

“…In multicellular organisms from Caenorhabditis elegans to Homo sapiens, the maintenance of homeostasis is dependent on the continual flow and processing of…”
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Modulation of A1 adenosine receptor signaling by peroxynitrite by GIUNTINI, Janette, GIUSTI, Laura, LUCACCHINI, Antonio, MAZZONI, Maria R

“…Nitric oxide (NO) is a gaseous free radical involved in many pathophysiological processes. During oxidative stress, NO, its derivatives and adenosine are…”
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Driving Forces in the Delivery of Penetratin Conjugated G Protein Fragment by Albrizio, Stefania, Giusti, Laura, D'Errico, Gerardino, Esposito, Cinzia, Porchia, Francesca, Caliendo, Gabriella, Novellino, Ettore, Mazzoni, Maria R, Rovero, Paolo, D'Ursi, Anna M

“…A42 is a chimera peptide consisting of Gαs(374-394)C379Athe 21-mer C terminus of the Gαs protein, able of adenosine inhibitory activityand penetratinthe 16…”
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Allosteric inhibition of [(125I)] ET-1 binding to ET(A) receptors by aldoxime and hydroxamic acid derivatives by Ahmed, Musa, Nencetti, Susanna, Mazzoni, Maria R, Porchia, Francesca, Antonelli, Federica, Lapucci, Annalina

“…Endothelin-1 (ET-1), a potent vasoconstrictor peptide, exerts its physiological effects by binding and activating specific G protein-coupled receptors, named…”
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Proteolytic fragmentation for epitope mapping by Mazzoni, Maria R, Porchia, Francesca, Hamm, Heidi E

“…The use of antigen fragments generated by specific proteolytic cleavage is a relatively simple "library" approach for epitope mapping in which possible…”
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Morphiceptin Analogues Containing a Dipeptide Mimetic Structure:  An Investigation on the Bioactive Topology at the μ-Receptor by Grieco, Paolo, Giusti, Laura, Carotenuto, Alfonso, Campiglia, Pietro, Calderone, Vincenzo, Lama, Teresa, Gomez-Monterrey, Isabel, Tartaro, Gianpaolo, Mazzoni, R, Novellino, Ettore

“…We describe the design, the conformational behavior, and the biological activity at the μ-opioid receptor of new morphiceptin analogues. In these analogues a…”
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2‘-C-Methyl Analogues of Selective Adenosine Receptor Agonists:  Synthesis and Binding Studies by Franchetti, Palmarisa, Cappellacci, Loredana, Marchetti, Stefano, Trincavelli, Letizia, Martini, Claudia, Mazzoni, Maria R, Lucacchini, Antonio, Grifantini, Mario

“…2‘-C-Methyl analogues of selective adenosine receptor agonists such as (R)-PIA, CPA, CCPA, NECA, and IB-MECA were synthesized in order to further investigate…”
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Interaction of Transducin with Light-activated Rhodopsin Protects It from Proteolytic Digestion by Trypsin by Mazzoni, Maria R., Hamm, Heidi E.

“…The tryptic cleavage pattern of transducin (Gt) in solution was compared with that in the presence of phospholipid vesicles, rod outer segment (ROS) membranes…”
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ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells by CECCARELLI, Francesca, SCAVUZZO, Maria C, GIUSTI, Laura, BIGINI, Gianni, COSTA, Barbara, CARNICELLI, Vittoria, ZUCCHI, Riccardo, LUCACCHINI, Antonio, MAZZONI, Maria R

“…Expression and pharmacological properties of endothelin receptors (ETRs) were investigated in H9c2 cardiomyoblasts. The mechanism of receptor-mediated…”
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A structure activity relationship study on position-2 of the Gαs C-terminal peptide able to inhibit Gs activation by A2A adenosine receptor by GRIECO, Paolo, ALBRIZIO, Stefania, D'URI, Anna Maria, GIUSTI, Laura, MAZZONI, Maria R, NOVELLINO, Ettore, ROVERO, Paolo

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Conformational analysis of the Gαs protein C-terminal region by D'ursi, Anna Maria, Albrizio, Stefania, Greco, Giovanni, Mazzeo, Sonia, Mazzoni, Maria R., Novellino, Ettore, Rovero, Paolo

“…The C‐terminal domain of the heterotrimeric G protein α‐subunits plays a key role in selective activation of G proteins by their cognate receptors. Several…”
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Increased inhibitory activity of protein kinase C on the serotonin transporter in OCD by Marazziti, D, Masala, I, Rossi, A, Hollander, E, Presta, S, Giannaccini, G, Mazzoni, M R, Dell'Osso, L, Lucacchini, A, Cassano, G B

“…Different observations show a reduced functionality of the serotonin (5-HT) transporter in obsessive-compulsive disorder (OCD) that might be due to a…”
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