Search Results - "Mazzon, Michela"

Targeting viral entry as a strategy for broad-spectrum antivirals [version 1; peer review: 3 approved] by Mazzon, Michela, Marsh, Mark

“…The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our…”
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KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides by Ficarelli, Mattia, Wilson, Harry, Pedro Galão, Rui, Mazzon, Michela, Antzin-Anduetza, Irati, Marsh, Mark, Neil, Stuart Jd, Swanson, Chad M

“…CpG dinucleotides are suppressed in most vertebrate RNA viruses, including HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication. The…”
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Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers by Penny, Christopher J., Vassileva, Kristin, Jha, Archana, Yuan, Yu, Chee, Xavier, Yates, Elizabeth, Mazzon, Michela, Kilpatrick, Bethan S., Muallem, Shmuel, Marsh, Mark, Rahman, Taufiq, Patel, Sandip

“…Two-pore channels (TPCs) are Ca2+-permeable ion channels localised to the endo-lysosomal system where they regulate trafficking of various cargoes including…”
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Pathogenesis of flavivirus infections: using and abusing the host cell by Fernandez-Garcia, Maria-Dolores, Mazzon, Michela, Jacobs, Michael, Amara, Ali

“…Flaviviruses, such as the dengue virus and the West Nile virus, are emerging arthropod-borne viruses that represent an immense global health problem…”
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Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes by Mazzon, Michela, Castro, Cecilia, Thaa, Bastian, Liu, Lifeng, Mutso, Margit, Liu, Xiang, Mahalingam, Suresh, Griffin, Julian L, Marsh, Mark, McInerney, Gerald M

“…Virus reprogramming of cellular metabolism is recognised as a critical determinant for viral growth. While most viruses appear to activate central energy…”
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DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing by Scutts, Simon R., Ember, Stuart W., Ren, Hongwei, Ye, Chao, Lovejoy, Christopher A., Mazzon, Michela, Veyer, David L., Sumner, Rebecca P., Smith, Geoffrey L.

“…Virus infection is sensed by pattern recognition receptors (PRRs) detecting virus nucleic acids and initiating an innate immune response. DNA-dependent protein…”
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A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus by Peters, Nicholas E, Ferguson, Brian J, Mazzon, Michela, Fahy, Aodhnait S, Krysztofinska, Ewelina, Arribas-Bosacoma, Raquel, Pearl, Laurence H, Ren, Hongwei, Smith, Geoffrey L

“…The innate immune system is critical in the response to infection by pathogens and it is activated by pattern recognition receptors (PRRs) binding to pathogen…”
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A mechanism for induction of a hypoxic response by vaccinia virus by Mazzon, Michela, Peters, Nicholas E., Loenarz, Christoph, Krysztofinska, Ewelina M., Ember, Stuart W. J., Ferguson, Brian J., Smith, Geoffrey L.

“…Viruses have evolved sophisticated strategies to exploit host cell function for their benefit. Here we show that under physiologically normal oxygen levels…”
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Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry by Mazzon, Michela, Ortega-Prieto, Ana Maria, Imrie, Douglas, Luft, Christin, Hess, Lena, Czieso, Stephanie, Grove, Joe, Skelton, Jessica Katy, Farleigh, Laura, Bugert, Joachim J, Wright, Edward, Temperton, Nigel, Angell, Richard, Oxenford, Sally, Jacobs, Michael, Ketteler, Robin, Dorner, Marcus, Marsh, Mark

“…Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised…”
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MFGM-enriched whey displays antiviral activity against common pediatric viruses in vitro by Kramer, Evelien, Patil, Ketki, Triantis, Vassilis, Bastiaans, Jan A H, Mazzon, Michela, Ramani, Sasirekha, Lambers, Tim T

“…Among the most common mucosal viral infections in infants are rotavirus, one of the main causes of severe gastroenteritis in infants and children up to 5…”
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Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus Strategy to Suppress Innate and Adaptive Immunity and Alter Virus Virulence by Strnadova, Pavla, Ren, Hongwei, Valentine, Robert, Mazzon, Michela, Sweeney, Trevor R, Brierley, Ian, Smith, Geoffrey L

“…Vaccinia virus (VACV) is the prototypic orthopoxvirus and the vaccine used to eradicate smallpox. Here we show that VACV strain Western Reserve protein 169 is…”
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The Nef Protein of the Macrophage Tropic HIV-1 Strain AD8 Counteracts Human BST-2/Tetherin by Giese, Sebastian, Lawrence, Scott P, Mazzon, Michela, Nijmeijer, Bernadien M, Marsh, Mark

“…Bone Marrow Stromal Cell Antigen 2 (BST-2)/tetherin inhibits the release of numerous enveloped viruses by physically tethering nascent particles to infected…”
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Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases by Riccio, Federica, Talapatra, Sandeep K, Oxenford, Sally, Angell, Richard, Mazzon, Michela, Kozielski, Frank

“…Members of the family constitute a severe risk to human health. Whilst effective drugs have been developed against the HCV, no antiviral therapy is currently…”
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Dengue Virus Replicon Expressing the Nonstructural Proteins Suffices To Enhance Membrane Expression of HLA Class I and Inhibit Lysis by Human NK Cells by Hershkovitz, Oren, Zilka, Alon, Bar-Ilan, Ahuva, Abutbul, Shai, Davidson, Andrew, Mazzon, Michela, Kümmerer, Beate M, Monsoengo, Alon, Jacobs, Michael, Porgador, Angel

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Lipid interactions during virus entry and infection by Mazzon, Michela, Mercer, Jason

“…Summary For entry and infection viruses have developed numerous strategies to subjugate indispensable cellular factors and functions. Host cell lipids and…”
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Dengue Virus NS5 Inhibits Interferon-α Signaling by Blocking Signal Transducer and Activator of Transcription 2 Phosphorylation by Mazzon, Michela, Jones, Meleri, Davidson, Andrew, Chain, Benjamin, Jacobs, Michael

“…Type I interferons (interferon [IFN]–α/β) are key mediators of innate antiviral responses. Inhibition of IFN-mediated signal transduction by dengue viruses…”
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Lipid interactions during virus entry and infection: Lipids and Viruses by Mazzon, Michela, Mercer, Jason

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Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity by Smith, Geoffrey L, Benfield, Camilla T O, Maluquer de Motes, Carlos, Mazzon, Michela, Ember, Stuart W J, Ferguson, Brian J, Sumner, Rebecca P

“…Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and…”
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A role for vaccinia virus protein C16 in reprogramming cellular energy metabolism by Mazzon, Michela, Castro, Cecilia, Roberts, Lee D, Griffin, Julian L, Smith, Geoffrey L

“…Vaccinia virus (VACV) is a large DNA virus that replicates in the cytoplasm and encodes about 200 proteins of which approximately 50 % may be non-essential for…”
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Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus Strategy to Suppress Innate and Adaptive Immunity and Alter Virus Virulence: e1005151 by Strnadova, Pavla, Ren, Hongwei, Valentine, Robert, Mazzon, Michela, Sweeney, Trevor R, Brierley, Ian, Smith, Geoffrey L

“…Vaccinia virus (VACV) is the prototypic orthopoxvirus and the vaccine used to eradicate smallpox. Here we show that VACV strain Western Reserve protein 169 is…”
Get full text