Search Results - "Mazzolini, G"

A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma by Sangro, B, Mazzolini, G, Ruiz, M, Ruiz, J, Quiroga, J, Herrero, I, Qian, C, Benito, A, Larrache, J, Olagüe, C, Boan, J, Peñuelas, I, Sádaba, B, Prieto, J

“…The aim of this phase I clinical trial was to assess the feasibility and safety of intratumoral administration of a first-generation adenoviral vector encoding…”
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Mesenchymal stem cells as therapeutic tools and gene carriers in liver fibrosis and hepatocellular carcinoma by Aquino, J B, Bolontrade, M F, García, M G, Podhajcer, O L, Mazzolini, G

“…Mesenchymal stem (stromal) cells (MSCs) are a source of circulating progenitors that are able to generate cells of all mesenchymal lineages and to cover…”
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Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice by Piccioni, Flavia, Malvicini, Mariana, Garcia, Mariana G, Rodriguez, Andrés, Atorrasagasti, Catalina, Kippes, Nestor, Piedra Buena, Ignacio T, Rizzo, Manglio M, Bayo, Juan, Aquino, Jorge, Viola, Manuela, Passi, Alberto, Alaniz, Laura, Mazzolini, Guillermo

“…Liver cirrhosis is characterized by an excessive accumulation of extracellular matrix components, including hyaluronan (HA). In addition, cirrhosis is…”
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SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage by Peixoto, E, Atorrasagasti, C, Aquino, J B, Militello, R, Bayo, J, Fiore, E, Piccioni, F, Salvatierra, E, Alaniz, L, García, M G, Bataller, R, Corrales, F, Gidekel, M, Podhajcer, O, Colombo, M I, Mazzolini, G

“…Secreted protein, acidic and rich in cysteine (SPARC) is involved in many biological process including liver fibrogenesis, but its role in acute liver damage…”
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Combination of 4-Methylumbelliferone and Adenoviral Gene Transfer of Interleukin-12 Reduced the Expression of Cancer Stem Cells Markers, and Showed a Potent Antitumor Effect in an Experimental Hepatocellular Carcinoma Model with Fibrosis by Rodriguez, M.M, Malvicini, M, Fiore, E, Bustillo, S.G, Piccioni, F, Peixoto, E, Atorrasagasti, C, Garcia, M, Alaniz, L, Mazzolini, G

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Inhibition of Hyaluronic Acid in Hepatocarcinogenesis: A Novel Approach to Target CD44 and Other Cancer Stem Cell Populations by Sukowati, C.H.C, Anfuso, B, Ie, S, Avellini, C, Radillo, O, Raseni, A, Fiore, E, Mazzolini, G, Tiribelli, C

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O143 SPARC (SECRETED PROTEIN ACIDIC AND RICH IN CYSTEINE) DEFICIENCY PROTECTS FROM CONCANAVALIN A-INDUCED HEPATITIS IN MICE by Peixoto, E, Atorrasagasti, C, Aquino, J, Militello, R, Bayo, J, Fiore, E, Piccioni, F, Salvatierra, E, Alaniz, L, Garcia, M.G, Bataller, R, Corrales, F, Gidekel, M, Podhajcer, O, Colombo, M.I, Mazzolini, G

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Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12 by Barajas, Miguel, Mazzolini, Guillermo, Genové, Guillem, Bilbao, Roberto, Narvaiza, Iñigo, Schmitz, Volker, Sangro, Bruno, Melero, Ignacio, Qian, Cheng, Prieto, Jesús

“…The use of gene therapy to enhance antitumor immunity has emerged as a promising procedure to fight cancer. In this study we have tested the ability of an…”
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Intratumoral injection of bone-marrow derived dendritic cells engineered to produce interleukin-12 induces complete regression of established murine transplantable colon adenocarcinomas by MELERO, I, DUARTE, M, RUIZ, J, SANGRO, B, GALOFRE, J. C, MAZZOLINI, G, BUSTOS, M, QIAN, C, PRIETO, J

“…Stimulation of the antitumor immune response by dendritic cells (DC) is critically dependent on their tightly regulated ability to produce interleukin-12…”
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The promise of gene therapy in gastrointestinal and liver diseases by Prieto, J, Herraiz, M, Sangro, B, Qian, C, Mazzolini, G, Melero, I, Ruiz, J

“…Gene therapy consists of the transfer of genetic material to cells to achieve a therapeutic goal. In the field of gastroenterology and hepatology gene therapy…”
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Gene therapy for liver diseases: recent strategies for treatment of viral hepatitis and liver malignancies by Schmitz, V, Qian, C, Ruiz, J, Sangro, B, Melero, I, Mazzolini, G, Narvaiza, I, Prieto, J

“…Gene therapy has emerged as a powerful and very plastic tool to regulate biological functions in diseased tissues with application in virtually all medical…”
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Gene therapy of liver diseases by Prieto, Jesus, Qian, Cheng, Hernandez-Alcoceba, Ruben, Gonzalez-Aseguinolaza, Gloria, Mazzolini, Guillermo, Sangro, Bruno, Kramer, M Gabriela

“…Many liver diseases lack satisfactory treatment and alternative therapeutic options are urgently needed. Gene therapy is a new mode of treatment for both…”
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Genetic heterogeneity in the toxicity to systemic adenoviral gene transfer of interleukin-12 by MAZZOLINI, G, NARVAIZA, I, PEREZ-DIEZ, A, RODRIGUEZ-CALVILLO, M, QIAN, C, SANGRO, B, RUIZ, J, PRIETO, J, MELERO, I

“…Despite the efficacy of IL-12 in cancer experimental models, clinical trials with systemic recombinant IL-12 showed unacceptable toxicity related to endogenous…”
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Pancreatic cancer escape variants that evade immunogene therapy through loss of sensitivity to IFNγ-induced apoptosis by MAZZOLINI, G, NARVAIZA, I, MARTINEZ-CRUZ, L. A, ARINA, A, BARAJAS, M, GALOFRE, J. C, QIAN, C, MATO, J. M, PRIETO, J, MELERO, I

“…Combined injections into experimental tumor nodules of adenovirus encoding IL-12 and certain chemokines are capable to induce immune-mediated complete…”
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Evaluation of 16 adult Disposable manual resuscitators by MAZZOLINI, Daniel G, MARSHALL, Nancy A

“…Disposable manual resuscitators are commonly used to ventilate patients during cardiopulmonary resuscitation, suctioning, and intrahospital transport, and…”
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Cytokine gene transfer into dendritic cells for cancer treatment by Tirapu, I, Rodriguez-Calvillo, M, Qian, C, Duarte, M, Smerdou, C, Palencia, B, Mazzolini, G, Prieto, J, Melero, I

“…Bone marrow-derived dendritic cells have been used to treat established experimental tumors by unleashing a cellular immune response against tumor antigens…”
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4Mu Decreases CD47 Expression on Hepatic Cancer Stem Cells and Primes a Potent Antitumor T Cell Response Induced by Interleukin-12 by Rodríguez, Marcelo M., Fiore, Esteban, Bayo, Juan, Atorrasagasti, Catalina, García, Mariana, Onorato, Agostina, Domínguez, Luciana, Malvicini, Mariana, Mazzolini, Guillermo

“…The tumor microenvironment (TME) represents a complex interplay between different cellular components, including tumor cells and cancer stem cells (CSCs), with…”
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Gene therapy of primary and metastatic liver tumors by Prieto, J, Qian, C, Melero, I, Sangro, B, Mazzolini, G, Narvaiza, I, Barajas, M

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FRI-037 - Inhibition of Hyaluronic Acid in Hepatocarcinogenesis: A Novel Approach to Target CD44 and Other Cancer Stem Cell Populations by Sukowati, C.H.C., Anfuso, B., Ie, S., Avellini, C., Radillo, O., Raseni, A., Fiore, E., Mazzolini, G., Tiribelli, C.

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FRI-067 - Combination of 4-Methylumbelliferone and Adenoviral Gene Transfer of Interleukin-12 Reduced the Expression of Cancer Stem Cells Markers, and Showed a Potent Antitumor Effect in an Experimental Hepatocellular Carcinoma Model with Fibrosis by Rodriguez, M.M., Malvicini, M., Fiore, E., Bustillo, S.G., Piccioni, F., Peixoto, E., Atorrasagasti, C., Garcia, M., Alaniz, L., Mazzolini, G.

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