Search Results - "Mazzola, Anne"

Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists by Toy, Weiyi, Weir, Hazel, Razavi, Pedram, Lawson, Mandy, Goeppert, Anne U, Mazzola, Anne Marie, Smith, Aaron, Wilson, Joanne, Morrow, Christopher, Wong, Wai Lin, De Stanchina, Elisa, Carlson, Kathryn E, Martin, Teresa S, Uddin, Sharmeen, Li, Zhiqiang, Fanning, Sean, Katzenellenbogen, John A, Greene, Geoffrey, Baselga, José, Chandarlapaty, Sarat

“…Recent studies have identified somatic mutations in patients with metastatic breast cancer and found some of them to promote estrogen-independent activation of…”
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GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy by Kasiewicz, Lisa N., Biswas, Souvik, Beach, Aaron, Ren, Huilan, Dutta, Chaitali, Mazzola, Anne Marie, Rohde, Ellen, Chadwick, Alexandra, Cheng, Christopher, Garcia, Sara P., Iyer, Sowmya, Matsumoto, Yuri, Khera, Amit V., Musunuru, Kiran, Kathiresan, Sekar, Malyala, Padma, Rajeev, Kallanthottathil G., Bellinger, Andrew M.

“…Lipid nanoparticles have demonstrated utility in hepatic delivery of a range of therapeutic modalities and typically deliver their cargo via low-density…”
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Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib by Williamson, Mark J, Blank, Jonathan L, Bruzzese, Frank J, Cao, Yueying, Daniels, J Scott, Dick, Lawrence R, Labutti, Jason, Mazzola, Anne M, Patil, Ashok D, Reimer, Corinne L, Solomon, Marjorie S, Stirling, Matthew, Tian, Yuan, Tsu, Christopher A, Weatherhead, Gabriel S, Zhang, Julie X, Rolfe, Mark

“…Strains within the genus Salinospora have been shown to produce complex natural products having antibiotic and antiproliferative activities. The biochemical…”
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Whole transcriptome profiling of patient-derived xenograft models as a tool to identify both tumor and stromal specific biomarkers by Bradford, James R, Wappett, Mark, Beran, Garry, Logie, Armelle, Delpuech, Oona, Brown, Henry, Boros, Joanna, Camp, Nicola J, McEwen, Robert, Mazzola, Anne Marie, D'Cruz, Celina, Barry, Simon T

“…The tumor microenvironment is emerging as a key regulator of cancer growth and progression, however the exact mechanisms of interaction with the tumor are…”
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Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models by Lee, Richard G., Mazzola, Anne Marie, Braun, Maurine C., Platt, Colin, Vafai, Scott B., Kathiresan, Sekar, Rohde, Ellen, Bellinger, Andrew M., Khera, Amit V.

“…VERVE-101 is an investigational in vivo CRISPR base-editing medicine designed to alter a single DNA base in the gene, permanently turn off hepatic protein…”
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In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates by Musunuru, Kiran, Chadwick, Alexandra C., Mizoguchi, Taiji, Garcia, Sara P., DeNizio, Jamie E., Reiss, Caroline W., Wang, Kui, Iyer, Sowmya, Dutta, Chaitali, Clendaniel, Victoria, Amaonye, Michael, Beach, Aaron, Berth, Kathleen, Biswas, Souvik, Braun, Maurine C., Chen, Huei-Mei, Colace, Thomas V., Ganey, John D., Gangopadhyay, Soumyashree A., Garrity, Ryan, Kasiewicz, Lisa N., Lavoie, Jennifer, Madsen, James A., Matsumoto, Yuri, Mazzola, Anne Marie, Nasrullah, Yusuf S., Nneji, Joseph, Ren, Huilan, Sanjeev, Athul, Shay, Madeleine, Stahley, Mary R., Fan, Steven H. Y., Tam, Ying K., Gaudelli, Nicole M., Ciaramella, Giuseppe, Stolz, Leslie E., Malyala, Padma, Cheng, Christopher J., Rajeev, Kallanthottathil G., Rohde, Ellen, Bellinger, Andrew M., Kathiresan, Sekar

“…Gene-editing technologies, which include the CRISPR–Cas nucleases 1 – 3 and CRISPR base editors 4 , 5 , have the potential to permanently modify…”
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Abstract 11274: VERVE-101—An Investigational Single-Course Gene Editing Medicine Targeting PCSK9—Durably and Potently Lowers PCSK9 and LDL-C Concentrations in Non-Human Primates by Lee, Richard, Mazzola, Anne M, Braun, Maurine, Platt, Colin, Vafai, Scott, Kathiresan, Sekar, rohde, ellen, Bellinger, Andrew M, Khera, Amit V

“…IntroductionVERVE-101 is an in vivo CRISPR base editing therapy designed to alter a single DNA base in the PCSK9 gene, permanently inactivate hepatic…”
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AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models by Weir, Hazel M, Bradbury, Robert H, Lawson, Mandy, Rabow, Alfred A, Buttar, David, Callis, Rowena J, Curwen, Jon O, de Almeida, Camila, Ballard, Peter, Hulse, Michael, Donald, Craig S, Feron, Lyman J L, Karoutchi, Galith, MacFaul, Philip, Moss, Thomas, Norman, Richard A, Pearson, Stuart E, Tonge, Michael, Davies, Gareth, Walker, Graeme E, Wilson, Zena, Rowlinson, Rachel, Powell, Steve, Sadler, Claire, Richmond, Graham, Ladd, Brendon, Pazolli, Ermira, Mazzola, Anne Marie, D'Cruz, Celina, De Savi, Chris

“…Fulvestrant is an estrogen receptor (ER) antagonist administered to breast cancer patients by monthly intramuscular injection. Given its present limitations of…”
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An investigational in vivo base editing medicine targeting ANGPTL3, VERVE-201, achieves precise and durable liver editing in nonclinical studies by Lee, Richard, Mazzola, Anne, Denizio, Jamie, Mizoguchi, Taiji, Clendaniel, Victoria, Garrity, Ryan, Cox, Nicholas, Glass, Zachary, Chamarthi, Hareesh, Flannigan, Sydney, Matsumoto, Yuri, Braun, Maurine, Kathiresan, Sekar, Biedenkapp, Joseph, Rohde, Ellen, Bellinger, Andrew, Khera, Amit

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Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers by Bihani, Teeru, Ezell, Scott A, Ladd, Brendon, Grosskurth, Shaun E, Mazzola, Anne Marie, Pietras, Mark, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M

“…Acquired resistance to PI3K/mTOR/Akt pathway inhibitors is often associated with compensatory feedback loops involving the activation of oncogenes. Here, we…”
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Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations by Ladd, Brendon, Mazzola, Anne Marie, Bihani, Teeru, Lai, Zhongwu, Bradford, James, Collins, Michael, Barry, Evan, Goeppert, Anne U, Weir, Hazel M, Hearne, Kelly, Renshaw, Jonathan G, Mohseni, Morvarid, Hurt, Elaine, Jalla, Sanjoo, Bao, Haifeng, Hollingsworth, Robert, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M

“…Although endocrine therapy is successfully used to treat patients with estrogen receptor (ER) positive breast cancer, a substantial proportion of this…”
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Abstract 3572: AZ5576, a novel potent and selective CDK9 inhibitor, induces rapid cell death and achieves efficacy in multiple preclinical hematological models by Cidado, Justin, Shen, Minhui, Grondine, Michael, Boiko, Scott, Wang, Haiyun, Borodovsky, Alexandra, Mazzola, Anne Marie, Wu, Alan, Lawson, Deborah, Ferguson, Douglas, Gao, Beirong, Cui, Andy, D’Cruz, Celina, Drew, Lisa

“…Abstract Cyclin-dependent kinase 9 (Cdk9) is a serine/threonine kinase that regulates elongation of transcription through phosphorylation of RNA polymerase II…”
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Abstract A146: Preclinical models relevant to the treatment of post-menopausal breast cancer by Pazolli, Ermira, Mazzola, Anne Marie, Curwen, Jon, Weir, Hazel, Kiessel, Casey, Grondine, Michael, D'Cruz, Celina, Zinda, Mike

“…Abstract The past decades have witnessed immense progress in the treatment of hormone-sensitive breast cancer. However, despite the success of agents targeting…”
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Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling by Michaud, Neil R, Wang, Youzhen, McEachern, Kristen A, Jordan, Jerold J, Mazzola, Anne Marie, Hernandez, Axel, Jalla, Sanjoo, Chesebrough, Jon W, Hynes, Mark J, Belmonte, Matthew A, Wang, Lidong, Kang, Jaspal S, Jovanovic, Jelena, Laing, Naomi, Jenkins, David W, Hurt, Elaine, Liang, Meina, Frantz, Christopher, Hollingsworth, Robert E, Simeone, Diane M, Blakey, David C, Bedian, Vahe

“…The hedgehog pathway has been implicated in the tumorigenesis, tumor progression, and metastasis of numerous human cancers. We generated the first fully human…”
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Abstract DDT01-03: Discovery and pre-clinical pharmacology of AZD9496: An oral, selective estrogen receptor down-regulator (SERD) by Weir, Hazel, Lawson, Mandy, Callis, Rowena, Hulse, Michael, Tonge, Michael, Davies, Gareth, Walker, Graeme, Rowlinson, Rachel, Curwen, Jon, Wilson, Zena, Powell, Steve, Bradbury, Robert, Rabow, Alfred, Donald, Craig, Buttar, David, Norman, Richard, de Almeida, Camila, Ballard, Peter, Currie, Gordon, Andrews, David, Richmond, Graham, Mazzola, Anne Marie, Pazolli, Ermira, Ladd, Brendon, D'Cruz, Celina, De Savi, Chris

“…Abstract With over 70% of breast cancers expressing estrogen receptor alpha protein (ERα), treatment with either anti-hormonal therapies that directly block…”
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Abstract 5462: MEDI3185, a potent anti-CXCR4 antibody, inhibits tumor cell migration, signaling and tumor growth in preclinical models by Kamal, Adeela, Wang, Youzhen, Steiner, Philipp, Mazzola, Anne-Marie, Wetzel, Leslie, Passino, Melissa, McDermott, Brenda, Huang, Keven, Bedian, Vahe, Greenberg, Norman

“…Abstract The chemokine receptor CXCR4 is a seven-transmembrane G-protein coupled receptor that mediates chemotaxis and cell migration upon stimulation via its…”
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Abstract 3910: Lead optimization of a series of 5-aminopyrazol-imidazopyridine compounds as potent anaplastic lymphoma kinase inhibitors active against clinically relevant ALK mutations by Yang, Bin, Saeh, Jamal C., Peng, Bo, Kamhi, Victor, Harrison, Rane, Harish, Reema, Wu, Allan, Whitston, David, Wang, Haiyun, Ye, Minwei, Wang, Suping, Code, Erin, Rivard, Caroline, Drew, Lisa, Mazzola, Anne Marie, Russell, Daniel J.

“…Abstract Despite the success of Crizotinib in treating NSCLC patients with EML4-ALK fusions, cancers eventually develop resistance via a variety of mechanisms…”
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Understanding the reasons for delayed referral for intrathecal baclofen therapy in pediatric patients with severe spasticity by Berman, Casey Melissa, Eppinger, Melissa Ann, Mazzola, Catherine Anne

“…Objective Intrathecal baclofen therapy (ITB) has been used in the treatment of spasticity and dystonia. In our pediatric movement disorder clinic, we noted a…”
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Imaging of congenital torticollis in infants: a retrospective study of an institutional protocol by Boyko, Nicholas, Eppinger, Melissa Ann, Straka-DeMarco, Deborah, Mazzola, Catherine Anne

“…OBJECTIVE The authors' objectives in this study were to evaluate their institutional protocol and create recommendations for radiographic imaging in infants…”
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Selective dorsal rhizotomy for spastic diplegia secondary to stroke in an adult patient by Eppinger, MelissaAnn, Berman, CaseyMelissa, Mazzola, CatherineAnne

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