Search Results - "Mazzio, Elizabeth A."

Basic concepts of epigenetics: Impact of environmental signals on gene expression by Mazzio, Elizabeth A., Soliman, Karam F.A.

“…Through epigenetic modifications, specific long-term phenotypic consequences can arise from environmental influence on slowly evolving genomic DNA. Heritable…”
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Therapeutic Potential of Thymoquinone in Triple-Negative Breast Cancer Prevention and Progression through the Modulation of the Tumor Microenvironment by Adinew, Getinet M, Taka, Equar, Mochona, Bereket, Badisa, Ramesh B, Mazzio, Elizabeth A, Elhag, Rashid, Soliman, Karam F A

“…To date, the tumor microenvironment (TME) has gained considerable attention in various areas of cancer research due to its role in driving a loss of immune…”
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Transcriptome Profile Analysis of Triple-Negative Breast Cancer Cells in Response to a Novel Cytostatic Tetrahydroisoquinoline Compared to Paclitaxel by Gangapuram, Madhavi, Mazzio, Elizabeth A., Redda, Kinfe K., Soliman, Karam F. A.

“…The absence of chemotherapeutic target hormone receptors in breast cancer is descriptive of the commonly known triple-negative breast cancer (TNBC) subtype…”
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Pericellular pH homeostasis is a primary function of the Warburg effect: Inversion of metabolic systems to control lactate steady state in tumor cells by Mazzio, Elizabeth A., Boukli, Nawal, Rivera, Nery, Soliman, Karam F. A.

“…The Warburg effect describes a heightened propensity of tumor cells to produce lactic acid in the presence or absence of O2. A generally held notion is that…”
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The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease by Mazzio, Elizabeth A, Close, Fran, Soliman, Karam F A

“…Future therapeutic intervention that could effectively decelerate the rate of degeneration within the substantia nigra pars compacta (SNc) could add years of…”
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The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro by Mazzio, Elizabeth A., Reams, Renee R., Soliman, Karam F.A.

“…The neurotoxin, 6-hydroxydopamine (6-OHDA) has been implicated in the neurodegenerative process of Parkinson's disease. The current study was designed to…”
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Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival by Mack, Nzinga, Mazzio, Elizabeth A, Bauer, David, Flores-Rozas, Hernan, Soliman, Karam F A

“…In the US, African Americans have a high death rate from triple-negative breast cancer (TNBC), characterized by lack of hormone receptors (ER, PR, HER2/ERRB2)…”
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Anti-inflammatory effects of thymoquinone in activated BV-2 microglial cells by Taka, Equar, Mazzio, Elizabeth A, Goodman, Carl B, Redmon, Natalie, Flores-Rozas, Hernan, Reams, Renee, Darling-Reed, Selina, Soliman, Karam F.A

“…Abstract Thymoquinone (TQ), the main pharmacological active ingredient within the black cumin seed ( Nigella sativa ) is believed to be responsible for the…”
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In vitro screening for the tumoricidal properties of international medicinal herbs by Mazzio, Elizabeth A, Soliman, Karam F.A

“…There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety…”
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Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2− in LPS/IFNγ activated glioma cells by Mazzio, Elizabeth A, Bauer, David, Mendonca, Patricia, Taka, Equar, Soliman, Karam F.A.

“…Chronic and acute central nervous system (CNS) inflammation are contributors toward neurological injury associated with head trauma, stroke, infection,…”
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The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated resistant glioma cell lines by Elhag, Rashid, Mazzio, Elizabeth A, Soliman, Karam F A

“…Glioblastoma multiforme (GBM) is an intractable brain tumor, associated with poor prognosis and low survival rate. Combination therapy such as surgery,…”
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Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A by MAZZIO, ELIZABETH A., SOLIMAN, KARAM F.A.

“…Background: Malignant melanoma cells can rapidly acquire phenotypic properties making them resistant to radiation and mainline chemotherapies such as…”
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Epigenetics and Nutritional Environmental Signals by Mazzio, Elizabeth A., Soliman, Karam F. A.

“…All terrestrial life is influenced by multi-directional flows of information about its environment, enabling malleable phenotypic change through signals,…”
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Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-Β-Boswellic Acid; ER/UPR Mediated Programmed Cell Death by MAZZIO, ELIZABETH A, LEWIS, CHARLES A, SOLIMAN, KARAM F.A

“…Background/Aim: Triple-negative breast cancer (TNBC) is characterized by the absence of hormone receptors (estrogen, progesterone and human epidermal growth…”
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Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response by Mazzio, Elizabeth A, Lewis, Charles A, Elhag, Rashid, Soliman, Karam F

“…Sepantronium bromide (YM-155) is believed to elicit apoptosis and mitotic arrest in tumor cells by reducing (BIRC5, survivin) mRNA. In this study, we monitored…”
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HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells by Mazzio, Elizabeth A, Soliman, Karam F A

“…Aggressive tumor malignancies are a consequence of delayed diagnosis, epigenetic/phenotype changes and chemo-radiation resistance. Histone deacetylases (HDACs)…”
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Synthesis of "neoprofen", a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances by Ramsubhag, Ron R, Massaro, Chelsea L, Dadich, Christina M, Janeczek, Andrew J, Hoang, Tung T, Mazzio, Elizabeth A, Eyunni, Suresh, Soliman, Karam F A, Dudley, Gregory B

“…3,3-Dimethylcyclopentanes (neopentylenes) are ubiquitous in Nature but largely absent from synthetic pharmaceutical libraries. Neopentylenes define a…”
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Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B by Eyunni, Suresh, Messeha, Samia S., Elshami, Faisel, Mazzio, Elizabeth, Zarmouh, Najla O., Soliman, Karam F. A.

“…Monoamine oxidase B inhibitors (MAO-BIs) are used in the early management of Parkinson’s disease (PD). Long-term suspected side effects of MAO-B classical…”
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In vitro screening of tumoricidal properties of international medicinal herbs: part II by Mazzio, Elizabeth A, Soliman, Karam F.A

“…With growing use of anticancer complementary and alternative medicines (CAMs) worldwide, there is a need to assess and screen commercially available natural…”
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Evaluation of endogenous acidic metabolic products associated with carbohydrate metabolism in tumor cells by Mazzio, Elizabeth A, Smith, Bruce, Soliman, Karam F. A

“…Tumor cells have a high tolerance for acidic and hypoxic microenvironments, also producing abundant lactic acid through accelerated glycolysis in the presence…”
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