Search Results - "Mazzilli, A."
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Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions
Published in Nature communications (23-04-2019)“…Bronchial premalignant lesions (PMLs) are precursors of lung squamous cell carcinoma, but have variable outcome, and we lack tools to identify and treat PMLs…”
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Single-molecule genome-wide mutation profiles of cell-free DNA for non-invasive detection of cancer
Published in Nature genetics (01-08-2023)“…Somatic mutations are a hallmark of tumorigenesis and may be useful for non-invasive diagnosis of cancer. We analyzed whole-genome sequencing data from 2,511…”
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Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression
Published in Clinical cancer research (01-09-2017)“…Lung cancer is the leading cause of cancer-related death in the United States. The molecular events preceding the onset of disease are poorly understood, and…”
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Survey on the interest and commitment of AIFM members to scientific activities (SicAS) – The initiative of the FutuRuS working group
Published in Physica medica (01-06-2023)“…[Display omitted] •We designed a national survey to quantify interest in scientific activities of MPEs.•34.7% of the respondents dedicated <10% of their…”
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Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways
Published in Scientific reports (28-10-2022)“…SARS-CoV-2 infection and disease severity are influenced by viral entry (VE) gene expression patterns in the airway epithelium. The similarities and…”
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Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution
Published in Science advances (01-12-2019)“…The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend against environmental insults. While studies have shown…”
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Latex peptidases of Calotropis procera for dehairing of leather as an alternative to environmentally toxic sodium sulfide treatment
Published in Bioprocess and biosystems engineering (01-09-2017)“…Dehairing of crude leather is a critical stage performed at the beginning of its processing to obtain industrially useful pieces. Tanneries traditionally apply…”
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A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism
Published in iScience (19-07-2024)“…Macrophages are critical for maintenance and repair of mucosal tissues. While functionally distinct subtypes of macrophage are known to have important roles in…”
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Elevated T cell repertoire diversity is associated with progression of lung squamous cell premalignant lesions
Published in Journal for immunotherapy of cancer (01-09-2021)“…ObjectiveThe immune response to invasive carcinoma has been the focus of published work, but little is known about the adaptive immune response to bronchial…”
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Shaping the Future of Research: a perspective from junior scientists [version 2; peer review: 2 approved]
Published in F1000 research (01-01-2014)“…The landscape of scientific research and funding is in flux as a result of tight budgets, evolving models of both publishing and evaluation, and questions…”
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Precancer Atlas to Drive Precision Prevention Trials
Published in Cancer research (Chicago, Ill.) (01-04-2017)“…Cancer development is a complex process driven by inherited and acquired molecular and cellular alterations. Prevention is the holy grail of cancer…”
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Graph Perceiver Network for Lung Tumor and Bronchial Premalignant Lesion Stratification from Histopathology
Published in The American journal of pathology (01-07-2024)“…Bronchial premalignant lesions (PMLs) precede the development of invasive lung squamous cell carcinoma (LUSC), posing a significant challenge in distinguishing…”
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The Case for a Pre-Cancer Genome Atlas (PCGA)
Published in Cancer prevention research (Philadelphia, Pa.) (01-02-2016)“…Understanding the earliest molecular and cellular events associated with cancer initiation remains a key bottleneck to transforming our approach to cancer…”
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Single-Cell Characterization of Pulmonary Nodules Implicates Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma
Published in Cancer research (Chicago, Ill.) (02-10-2023)“…A greater understanding of molecular, cellular, and immunological changes during the early stages of lung adenocarcinoma development could improve diagnostic…”
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Airway-Associated Macrophages in Homeostasis and Repair
Published in Cell reports (Cambridge) (29-12-2020)“…There is an increasing appreciation for the heterogeneity of myeloid lineages in the lung, but relatively little is known about populations specifically…”
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PO-1664 Faster treatment using Halcyon linear accelerator: the experience of Parma University Hospital
Published in Radiotherapy and oncology (01-05-2022)Get full text
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Abstract 896: The airway field of injury reflects gene expression changes associated with the presence of lung squamous premalignant lesions
Published in Cancer research (Chicago, Ill.) (15-07-2016)“…Abstract Lung squamous cell carcinoma (SCC) arises in the epithelial layer of the bronchial airways and is preceded by the development of premalignant lesions…”
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Vitamin D Repletion Reduces the Progression of Premalignant Squamous Lesions in the NTCU Lung Squamous Cell Carcinoma Mouse Model
Published in Cancer prevention research (Philadelphia, Pa.) (01-10-2015)“…The chemopreventive actions of vitamin D were examined in the N-nitroso-tris-chloroethylurea (NTCU) mouse model, a progressive model of lung squamous cell…”
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PD-0728 Knowledge-Based automatic plan optimization for whole breast Radiotherapy with Halcyon
Published in Radiotherapy and oncology (01-05-2022)Get full text
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PO-1651 Inter-institute transferability of KB plan prediction models for FB LWB on DIBH candidates
Published in Radiotherapy and oncology (01-05-2023)Get full text
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