Search Results - "Mazzella, Matthew J"

Combined exposure to lead, cadmium, mercury, and arsenic and kidney health in adolescents age 12–19 in NHANES 2009–2014 by Sanders, Alison P., Mazzella, Matthew J., Malin, Ashley J., Hair, Gleicy M., Busgang, Stefanie A., Saland, Jeffrey M., Curtin, Paul

“…Occupational and environmental exposures to toxic metals are established risk factors for the development of hypertension and kidney disease in adults. There…”
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Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model by Choi, Jennifer H.K, Berger, Jason D, Mazzella, Matthew J, Morales-Corraliza, Jose, Cataldo, Anne M, Nixon, Ralph A, Ginsberg, Stephen D, Levy, Efrat, Mathews, Paul M

“…Individuals with Down syndrome develop β-amyloid deposition characteristic of early-onset Alzheimer's disease (AD) in mid-life, presumably because of an extra…”
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In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice by Morales-Corraliza, Jose, Mazzella, Matthew J, Berger, Jason D, Diaz, Nicole S, Choi, Jennifer H K, Levy, Efrat, Matsuoka, Yasuji, Planel, Emmanuel, Mathews, Paul M

“…The metabolism of the amyloid precursor protein (APP) and tau are central to the pathobiology of Alzheimer's disease (AD). We have examined the in vivo…”
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Modulation of Aβ generation by small ubiquitin-like modifiers does not require conjugation to target proteins by Dorval, Véronique, Mazzella, Matthew J., Mathews, Paul M., Hay, Ronald T., Fraser, Paul E.

“…The sequential processing of the APP (amyloid precursor protein) by the β- and γ-secretase and generation of the Aβ (amyloid-β) peptide is a primary…”
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Dissociated Phenotypes in Presenilin Transgenic Mice Define Functionally Distinct γ-Secretases by Mastrangelo, Peter, Mathews, Paul M., Chishti, M. Azhar, Schmidt, Stephen D., Gu, Yongjun, Yang, Jing, Mazzella, Matthew J., Coomaraswamy, Janaky, Horne, Patrick, Strome, Bob, Pelly, Heather, Levesque, Georges, Ebeling, Chris, Jiang, Ying, Nixon, Ralph A., Rozmahel, Richard, Fraser, Paul E., St George-Hyslop, Peter, Carlson, George A., Westaway, David, Prusiner, Stanley B.

“…γ-secretase depends on presence of presenilins (PS), Nct, Aph-1, and PEN-2 within a core complex. This endoproteolytic activity cleaves within transmembrane…”
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Inflammatory marker levels in children with tobacco smoke exposure by Mahabee-Gittens, E Melinda, Matt, Georg E, Mazzella, Matthew J, Doucette, John T, Ratnani, Parita, Merianos, Ashley L

“…Tobacco smoke exposure (TSE) has inflammatory and immunosuppressive effects which may be associated with altered levels of inflammatory markers and pediatric…”
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Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes by Morales-Corraliza, Jose, Wong, Harrison, Mazzella, Matthew J, Che, Shaoli, Lee, Sang Han, Petkova, Eva, Wagner, Janice D, Hemby, Scott E, Ginsberg, Stephen D, Mathews, Paul M

“…Epidemiological findings suggest that diabetic individuals are at a greater risk for developing Alzheimer's disease (AD). To examine the mechanisms by which…”
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Quality assurance and harmonization for targeted biomonitoring measurements of environmental organic chemicals across the Children's Health Exposure Analysis Resource laboratory network by Kannan, Kurunthachalam, Stathis, Alexa, Mazzella, Matthew J., Andra, Syam S., Barr, Dana Boyd, Hecht, Stephen S., Merrill, Lori S., Galusha, Aubrey L., Parsons, Patrick J.

“…A consortium of laboratories established under the Children's Health Exposure Analysis Resource (CHEAR) used a multifaceted quality assurance program to…”
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Evaluating inter-study variability in phthalate and trace element analyses within the Children’s Health Exposure Analysis Resource (CHEAR) using multivariate control charts by Mazzella, Matthew J., Barr, Dana Boyd, Kannan, Kurunthachalam, Amarasiriwardena, Chitra, Andra, Syam S., Gennings, Chris

“…Background The Children’s Health Exposure Analysis Resource (CHEAR) program allows researchers to expand their research goals by offering the assessment of…”
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A cross-validation based approach for estimating specific gravity in elementary-school aged children using a nonlinear model by Busgang, Stefanie A., Andra, Syam S., Curtin, Paul, Colicino, Elena, Mazzella, Matthew J., Bixby, Moira, Sanders, Alison P., Meeker, John D., Hauptman, Marissa, Yelamanchili, Shirisha, Phipatanakul, Wanda, Gennings, Chris

“…Environmental research often relies on urinary biomarkers which require dilution correction to accurately measure exposures. Specific gravity (SG) and…”
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Comparison of Liquid Chromatography Mass Spectrometry and Enzyme-Linked Immunosorbent Assay Methods to Measure Salivary Cotinine Levels in Ill Children by Mahabee-Gittens, E Melinda, Mazzella, Matthew J, Doucette, John T, Merianos, Ashley L, Stone, Lara, Wullenweber, Chase A, A Busgang, Stefanie, Matt, Georg E

“…: Cotinine is the preferred biomarker to validate levels of tobacco smoke exposure (TSE) in children. Compared to enzyme-linked immunosorbent assay methods…”
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Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice by Choi, Jennifer H K, Kaur, Gurjinder, Mazzella, Matthew J, Morales-Corraliza, Jose, Levy, Efrat, Mathews, Paul M

“…Early endosomal changes, a prominent pathology in neurons early in Alzheimer's disease, also occur in neurons and peripheral tissues in Down syndrome. While in…”
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Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model by Morales-Corraliza, Jose, Schmidt, Stephen D, Mazzella, Matthew J, Berger, Jason D, Wilson, Donald A, Wesson, Daniel W, Jucker, Mathias, Levy, Efrat, Nixon, Ralph A, Mathews, Paul M

“…Abstract Although anti-human β-amyloid (Aβ) immunotherapy clears brain β-amyloid plaques in Alzheimer's disease (AD), targeting additional brain plaque…”
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Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model by Wesson, Daniel W., Morales-Corraliza, Jose, Mazzella, Matthew J., Wilson, Donald A., Mathews, Paul M.

“…► Olfaction is dysfunctional in mouse models of the Alzheimer's disease (AD). ► Chronic anti-murine amyloid-β immunization preserved odor habituation behavior…”
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Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice by Mahler, Jasmin, Morales-Corraliza, Jose, Stolz, Julia, Skodras, Angelos, Radde, Rebecca, Duma, Carmen C, Eisele, Yvonne S, Mazzella, Matthew J, Wong, Harrison, Klunk, William E, Nilsson, K. Peter R, Staufenbiel, Matthias, Mathews, Paul M, Jucker, Mathias, Wegenast-Braun, Bettina M

“…Abstract Endogenous murine amyloid-β peptide (Aβ) is expressed in most Aβ precursor protein (APP) transgenic mouse models of Alzheimer's disease but its…”
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Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice by Morales-Corraliza, Jose, Berger, Jason D, Mazzella, Matthew J, Veeranna, Neubert, Thomas A, Ghiso, Jorge, Rao, Mala V, Staufenbiel, Matthias, Nixon, Ralph A, Mathews, Paul M

“…Abstract We report that neuronal overexpression of the endogenous inhibitor of calpains, calpastatin (CAST), in a mouse model of human Alzheimer's disease (AD)…”
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Aβ measurement by enzyme-linked immunosorbent assay by Schmidt, Stephen D, Mazzella, Matthew J, Nixon, Ralph A, Mathews, Paul M

“…The neuritic plaque in the brain of Alzheimer's disease patients consists of an amyloid composed primarily of Aβ, an approximately 4-kDa peptide derived from…”
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In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: Greater stability of sAPP in the β-amyloid-depositing mice by Morales-Corraliza, Jose, Mazzella, Matthew J, Berger, Jason D, Diaz, Nicole S, Choi, Jennifer H.K, Levy, Efrat, Matsuoka, Yasuji, Planel, Emmanuel, Mathews, Paul M

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O2-02-01: Endogenous Aβ enhances memory retention in the rat by Mathews, Paul M, Garcia-Osta, Ana, Mazzella, Matthew J, Alberini, Cristina M

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P1-079: Calpain inhibition by calpastatin overexpression reduces β-amyloid deposition in an APP transgenic mouse by Morales-Corraliza, Jose, Berger, Jason D, Mazzella, Matthew J, Staufenbiel, Matthias, Rao, Mala V, Nixon, Ralph A, Mathews, Paul M

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