Search Results - "Mazurier, F"

Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells by Caillot, M., Bourgeais, J., Dakik, H., Costé, É., Mazure, N. M., Lelièvre, É., Coqueret, O., Hérault, O., Mazurier, F., Sola, B.

“…Cancer cells are characterized by the Warburg effect, a shift from mitochondrial respiration to oxidative glycolysis. We report here the crucial role of cyclin…”
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Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment by Mazurier, Frédéric, Gan, Olga I., McKenzie, Joby L., Doedens, Monica, Dick, John E.

“…Knowledge of the composition and interrelationship of the various hematopoietic stem cells (HSCs) that comprise the human HSC pool and the consequence of…”
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The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A by Dedieu, S, Canron, X, Rezvani, H R, Bouchecareilh, M, Mazurier, F, Sinisi, R, Zanda, M, Moenner, M, Bikfalvi, A, North, S

“…Amifostine (WR-2721, delivered as Ethyol) is a phosphorylated aminothiol compound clinically used in addition to cis-platinum to reduce the toxic side effects…”
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Steady state peripheral blood stem cells fate depends on HIF expression and antioxydants by Brunet de la Grange, P, Chevaleyre, J, Vlaski, M, Duchez, P, Lapostolle, V, Mazurier, F, Villacreces, A, Praloran, V, Ivanovic, Z

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A knock-in mouse model of congenital erythropoietic porphyria by Ged, C., Mendez, M., Robert, E., Lalanne, M., Lamrissi-Garcia, I., Costet, P., Daniel, J.Y., Dubus, P., Mazurier, F., Moreau-Gaudry, F., de Verneuil, H.

“…Congenital erythropoietic porphyria (CEP) is a recessive autosomal disorder characterized by a deficiency in uroporphyrinogen III synthase (UROS), the fourth…”
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Control of transgene expression using local hyperthermia in combination with a heat-sensitive promoter by Vekris, A., Maurange, C., Moonen, C., Mazurier, F., De Verneuil, H., Canioni, P., Voisin, P.

“…Background Local production of therapeutic proteins, e.g. for cancer treatments, is based on gene therapy approaches and requires tight spatial and temporal…”
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Successful therapeutic effect in a mouse model of erythropoietic protoporphyria by partial genetic correction and fluorescence-based selection of hematopoietic cells by FONTANELLAS, A, MENDEZ, M, ENRIQUEZ DE SALAMANCA, R, DE VERNEUIL, H, MAZURIER, F, CARIO-ANDRE, M, NAVARRO, S, GED, C, TAINE, L, GERONIMI, F, RICHARD, E, MOREAU-GAUDRY, F

“…Erythropoietic protoporphyria is characterized clinically by skin photosensitivity and biochemically by a ferrochelatase deficiency resulting in an excessive…”
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Gene transfer of the uroporphyrinogen III synthase cDNA into haematopoietic progenitor cells in view of a future gene therapy in congenital erythropoietic porphyria by Mazurier, F., Moreau‐Gaudry, F., Salesse, S., Barbot, C., Ged, C., Reiffers, J., Verneuil, H.

“…Congenital erythropoietic porphyria (CEP) is an inherited metabolic disorder characterized by an overproduction and accumulation of porphyrins in bone marrow…”
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Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression by Wang, Lisheng, Menendez, Pablo, Shojaei, Farbod, Li, Li, Mazurier, Frederick, Dick, John E, Cerdan, Chantal, Levac, Krysta, Bhatia, Mickie

“…Despite the need for alternative sources of human hematopoietic stem cells (HSCs), the functional capacity of hematopoietic cells generated from human…”
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Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells by Dick, John E, Mazurier, Frédéric, Doedens, Monica, Gan, Olga I

“…A major problem hampering effective stem cell-based therapies is the absence of a clear understanding of the human hematopoietic stem cell (HSC) pool…”
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Rapid analysis and efficient selection of human transduced primitive hematopoietic cells using the humanized S65T green fluorescent protein by MAZURIER, F, MOREAU-GAUDRY, F, DE VERNEUIL, H, MAGUER-SATTA, V, SALESSE, S, PIGEONNIER-LAGARDE, V, GED, C, BELLOC, F, LACOMBE, F, MAHON, F. X, REIFFERS, J

“…We have developed an efficient and rapid method to analyze transduction in human hematopoietic cells and to select them. We constructed two retroviral vectors…”
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Correction of the enzyme defect in cultured congenital erythropoietic porphyria disease cells by retrovirus-mediated gene transfer by Moreau-Gaudry, F, Ged, C, Barbot, C, Mazurier, F, Boiron, J M, Bensidhoum, M, Reiffers, J, de Verneuil, H

“…Congenital erythropoietic porphyria (CEP) is a genetic disease characterized by an overproduction and accumulation of porphyrins in bone marrow. The enzyme…”
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Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells by Caillot, M., Bourgeais, J., Dakik, H., Costé, É., Mazure, Nathalie M, Lelièvre, É., Coqueret, O., Hérault, O., Mazurier, F., Sola, B.

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Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells by Caillot, M., Bourgeais, J., Dakik, H., Costé, É., Mazure, Nathalie M, Lelièvre, É., Coqueret, O., Hérault, O., Mazurier, F., Sola, B.

“…Abstract Cancer cells are characterized by the Warburg effect, a shift from mitochondrial respiration to oxidative glycolysis. We report here the crucial role…”
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Correction of the enzyme deficit of bone marrow cells in congenital erythropoietic porphyria by retroviral gene transfer by Moreau-Gaudry, F, Barbot, C, Mazurier, F, Mahon, F X, Reiffers, J, Ged, C, de Verneuil, H

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Horizontal meta-analysis identifies common deregulated genes across AML subgroups providing a robust prognostic signature by Nehme, Ali, Dakik, Hassan, Picou, Frédéric, Cheok, Meyling, Preudhomme, Claude, Dombret, Hervé, Lambert, Juliette, Gyan, Emmanuel, Pigneux, Arnaud, Récher, Christian, Béné, Marie C., Gouilleux, Fabrice, Zibara, Kazem, Herault, Olivier, Mazurier, Frédéric

“…Advances in transcriptomics have improved our understanding of leukemic development and helped to enhance the stratification of patients. The tendency of…”
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PS989 ABNORMAL DNA METHYLATION MODIFIES HOX GENES EXPRESSION IN BONE MARROW MESENCHYMAL STROMAL CELLS OF MYELODYSPLASIAS AND DE NOVO ACUTE MYELOID LEUKEMIAS by Roux, B., Picou, F., Vignon, C., Debeissat, C., Gallay, N., Koubi, M., Hirsch, P., Ducrocq, E., Foucault, A., Ravalet, N., Mazurier, F., Rouleux‐Bonnin, F., Gouilleux, F., Hunault, M., Mosser, J., Etcheverry, A., Le Nail, L.‐R., Delhommeau, F., Gyan, E., Domenech, J., Herault, O.

“…Background: In the context of myelodysplasias (MDS) and acute mydeloid leukemias (AML), the discovery in hematopoietic cells of aberrant DNA methylation…”
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PF200 CARBENOXOLONE REVERSES MICROENVIRONMENT‐INDUCED CHEMORESISTANCE OF ACUTE MYELOID LEUKEMIA by Kouzi, F., Zibara, K., Picou, F., Bourgeais, J., Gallay, N., Dakik, H., Roux, B., Hamard, S., Le Nail, L.‐R., Hleihel, R., Foucault, A., Ravalet, N., Rouleux‐Bonnin, F., Gouilleux, F., Mazurier, F., Gyan, E., Domenech, J., El‐Sabban, M., Herault, O.

“…Background: Bone marrow niche of acute myeloid leukemia (AML) regulates leukemic progression by favoring leukemic cell quiescence and chemoresistance. Niche…”
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Human cell engraftment after busulfan or irradiation conditioning of NOD/SCID mice by Robert-Richard, E, Ged, C, Ortet, J, Santarelli, X, Lamrissi-Garcia, I, de Verneuil, H, Mazurier, F

“…INSERM E217, Bordeaux cedex, France. Human hematopoietic stem cell (HSC) xenotransplantation in NOD/SCID mice requires recipient conditioning, classically…”
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Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion by Madlambayan, Gerard J., Rogers, Ian, Kirouac, Daniel C., Yamanaka, Nobuko, Mazurier, Frèdèric, Doedens, Monica, Casper, Robert F., Dick, John E., Zandstra, Peter W.

“…The absence of effective strategies for the ex vivo expansion of human hematopoietic stem cells (HSCs) limits the development of many cell-based therapies…”
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