Search Results - "Mazure, Nathalie M"

Primary Cilium in Cancer Hallmarks by Fabbri, Lucilla, Bost, Frédéric, Mazure, Nathalie M

“…The primary cilium is a solitary, nonmotile and transitory appendage that is present in virtually all mammalian cells. Our knowledge of its ultrastructure and…”
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Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains by Bellot, Grégory, Garcia-Medina, Raquel, Gounon, Pierre, Chiche, Johanna, Roux, Danièle, Pouysségur, Jacques, Mazure, Nathalie M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hypoxia-inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH by CHICHE, Johanna, LLC, Karine, LAFERRIERE, Julie, TROTTIER, Eric, DAYAN, Frédéric, MAZURE, Nathalie M, BRAHIMI-HORN, M. Christiane, POUYSSEGUR, Jacques

“…Acidosis of the tumor microenvironment is typical of a malignant phenotype, particularly in hypoxic tumors. All cells express multiple isoforms of carbonic…”
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Role of Hypoxia and Metabolism in the Development of Neointimal Hyperplasia in Arteriovenous Fistulas by Sadaghianloo, Nirvana, Contenti, Julie, Dardik, Alan, Mazure, Nathalie M

“…For patients with end-stage renal disease requiring hemodialysis, their vascular access is both their lifeline and their Achilles heel. Despite being…”
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Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia by Mazure, Nathalie M., Pouysségur, Jacques

“…Normal and tumor cells subjected to a hypoxic microenvironment show evidence of autophagy. We hypothesize that cells will sense hypoxia as a warning signal to…”
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Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux by Giuliano, Sandy, Cormerais, Yann, Dufies, Maeva, Grépin, Renaud, Colosetti, Pascal, Belaid, Amine, Parola, Julien, Martin, Anthony, Lacas-Gervais, Sandra, Mazure, Nathalie M, Benhida, Rachid, Auberger, Patrick, Mograbi, Baharia, Pagès, Gilles

“…Metastatic renal cell carcinomas (mRCC) are highly vascularized tumors that are a paradigm for the treatment with antiangiogenesis drugs targeting the vascular…”
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Targeting cancer and immune cell metabolism with the complex I inhibitors metformin and IACS‐010759 by Pujalte‐Martin, Marc, Belaïd, Amine, Bost, Simon, Kahi, Michel, Peraldi, Pascal, Rouleau, Matthieu, Mazure, Nathalie M., Bost, Frédéric

“…Metformin and IACS‐010759 are two distinct antimetabolic agents. Metformin, an established antidiabetic drug, mildly inhibits mitochondrial complex I, while…”
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The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma by Ambrosetti, Damien, Dufies, Maeva, Dadone, Bérengère, Durand, Matthieu, Borchiellini, Delphine, Amiel, Jean, Pouyssegur, Jacques, Rioux-Leclercq, Nathalie, Pages, Gilles, Burel-Vandenbos, Fanny, Mazure, Nathalie M

“…Clear-cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. Although ccRCC is characterized by common recurrent genetic abnormalities,…”
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Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation by Ferecatu, Ioana, Canal, Frédéric, Fabbri, Lucilla, Mazure, Nathalie M, Bouton, Cécile, Golinelli-Cohen, Marie-Pierre

“…Biogenesis of iron-sulfur clusters (ISC) is essential to almost all forms of life and involves complex protein machineries. This process is initiated within…”
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Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival by Pelletier, Joffrey, Bellot, Grégory, Gounon, Pierre, Lacas-Gervais, Sandra, Pouysségur, Jacques, Mazure, Nathalie M

“…The hypoxia-inducible factor 1 (HIF-1), in addition to genetic and epigenetic changes, is largely responsible for alterations in cell metabolism in hypoxic…”
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The marine-derived HIF-1α inhibitor, Yardenone 2, reduces prostate cancer cell proliferation by targeting HIF-1 target genes by Peng, Siyong, Guo, Yingbo, Irondelle, Marie, Mazzu, Abigail, Kahi, Michel, Ferreira Montenegro, Paula, Bost, Frédéric, Mazure, Nathalie M

“…Prostate cancer (PCa) ranks as the second most prevalent cancer in men, with advanced stages posing significant treatment challenges. Given its solid tumor…”
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Immunosuppressive Mesenchymal Stromal Cells Derived from Human-Induced Pluripotent Stem Cells Induce Human Regulatory T Cells In Vitro and In Vivo by Roux, Clémence, Saviane, Gaëlle, Pini, Jonathan, Belaïd, Nourhène, Dhib, Gihen, Voha, Christine, Ibáñez, Lidia, Boutin, Antoine, Mazure, Nathalie M, Wakkach, Abdelilah, Blin-Wakkach, Claudine, Rouleau, Matthieu

“…Despite mesenchymal stromal cells (MSCs) are considered as a promising source of cells to modulate immune functions on cells from innate and adaptive immune…”
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LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition by Proteau, Sarah, Krossa, Imène, Husser, Chrystel, Guéguinou, Maxime, Sella, Federica, Bille, Karine, Irondelle, Marie, Dalmasso, Mélanie, Barouillet, Thibault, Cheli, Yann, Pisibon, Céline, Arrighi, Nicole, Nahon‐Estève, Sacha, Martel, Arnaud, Gastaud, Lauris, Lassalle, Sandra, Mignen, Olivier, Brest, Patrick, Mazure, Nathalie M, Bost, Frédéric, Baillif, Stéphanie, Landreville, Solange, Turcotte, Simon, Hasson, Dan, Carcamo, Saul, Vandier, Christophe, Bernstein, Emily, Yvan‐Charvet, Laurent, Levesque, Mitchell P, Ballotti, Robert, Bertolotto, Corine, Strub, Thomas

“…Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout…”
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The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells by Loubiere, Camille, Clavel, Stephan, Gilleron, Jerome, Harisseh, Rania, Fauconnier, Jeremy, Ben-Sahra, Issam, Kaminski, Lisa, Laurent, Kathiane, Herkenne, Stephanie, Lacas-Gervais, Sandra, Ambrosetti, Damien, Alcor, Damien, Rocchi, Stephane, Cormont, Mireille, Michiels, Jean-François, Mari, Bernard, Mazure, Nathalie M., Scorrano, Luca, Lacampagne, Alain, Gharib, Abdallah, Tanti, Jean-François, Bost, Frederic

“…Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the…”
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Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies by Mancini, Stéphane J C, Balabanian, Karl, Corre, Isabelle, Gavard, Julie, Lazennec, Gwendal, Le Bousse-Kerdilès, Marie-Caroline, Louache, Fawzia, Maguer-Satta, Véronique, Mazure, Nathalie M, Mechta-Grigoriou, Fatima, Peyron, Jean-François, Trichet, Valérie, Herault, Olivier

“…Knowledge about the hematopoietic niche has evolved considerably in recent years, in particular through analyzes, mouse models and the use of xenografts. Its…”
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Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli by Chiche, Johanna, Rouleau, Matthieu, Gounon, Pierre, Brahimi-Horn, M. Christiane, Pouysségur, Jacques, Mazure, Nathalie M.

“…It is well established that cells exposed to the limiting oxygen microenvironment (hypoxia) of tumors acquire resistance to chemotherapy, through mechanisms…”
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Overexpression of carbonic anhydrase XII in tissues from resectable non‐small cell lung cancers is a biomarker of good prognosis by Ilie, Marius I., Hofman, Véronique, Ortholan, Cécile, Ammadi, Reda El, Bonnetaud, Christelle, Havet, Katia, Venissac, Nicolas, Mouroux, Jerôme, Mazure, Nathalie M., Pouysségur, Jacques, Hofman, Paul

“…The pattern of protein expression in tumors is under the influence of nutrient stress, hypoxia and low pH, which determines the survival of neoplastic cells…”
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Oxygen shortage: Himalayan adventures in an incubator by Mazure, Nathalie M

“…Every day, cells face hypoxic conditions without anyone realizing it. New research by Tan et al ( 2024 ) reveals that differentiated cells in standard cell…”
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Local Mitochondrial-Endolysosomal Microfusion Cleaves Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia by Brahimi-Horn, M. Christiane, Lacas-Gervais, Sandra, Adaixo, Ricardo, Ilc, Karine, Rouleau, Matthieu, Notte, Annick, Dieu, Marc, Michiels, Carine, Voeltzel, Thibault, Maguer-Satta, Véronique, Pelletier, Joffrey, Ilie, Marius, Hofman, Paul, Manoury, Bénédicte, Schmidt, Alexander, Hiller, Sebastian, Pouysségur, Jacques, Mazure, Nathalie M.

“…The oxygen-limiting (hypoxic) microenvironment of tumors induces metabolic reprogramming and cell survival, but the underlying mechanisms involving…”
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Hypoxia-induced autophagy: cell death or cell survival? by Mazure, Nathalie M, Pouysségur, Jacques

“…Hypoxia (∼3–0.1% oxygen) is capable of rapidly inducing, via the hypoxia-inducible factor (HIF-1), a cell survival response engaging autophagy. This process is…”
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