Search Results - "Mazur, S J"

The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis by Lu, X, Mazur, S J, Lin, T, Appella, E, Xu, Y

“…Nanog is a transcription factor required for maintaining the pluripotency of embryonic stem cells, and is not expressed in most normal adult tissues. However,…”
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p53 N-terminal phosphorylation: a defining layer of complex regulation by MILLER JENKINS, Lisa M, DURELL, Stewart R, MAZUR, Sharlyn J, APPELLA, Ettore

“…The p53 tumor suppressor is a critical component of the cellular response to stress. As it can inhibit cell growth, p53 is mutated or functionally inactivated…”
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Repair of oxidative DNA base lesions induced by fluorescent light is defective in xeroderma pigmentosum group A cells by Leonora J., Lipinski, Hoehr, Nelci, Mazur, Sharlyn J., Dianov, Grigory L., Sentürker, Sema, Dizdaroglu, Miral, Bohr, Vilhelm A.

“…Fluorescent light (FL) has been shown to generate free radicals within cells, however, the specific chemical nature of DNA damage induced by FL has not…”
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Dimerization of Escherichia coli UvrA and its binding to undamaged and ultraviolet light damaged DNA by Mazur, Sharlyn J, Grossman, Lawrence

“…The initial stages in the repair of damaged DNA by the Escherichia coli uvr system involve the recognition of damage by UvrA. We have examined in detail the…”
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Repair of DNA-containing pyrimidine dimers by Grossman, L, Caron, P R, Mazur, S J, Oh, E Y

“…Ultraviolet light-induced pyrimidine dimers in DNA are recognized and repaired by a number of unique cellular surveillance systems. The most direct biochemical…”
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The Processing of Holliday Junctions by BLM and WRN Helicases Is Regulated by p53 by Yang, Qin, Zhang, Ran, Wang, Xin Wei, Spillare, Elisa A, Linke, Steven P, Subramanian, Deepa, Griffith, Jack D, Li, Ji Liang, Hickson, Ian D, Shen, Jiang Cheng, Loeb, Lawrence A, Mazur, Sharlyn J, Appella, Ettore, Brosh, Jr, Robert M, Karmakar, Parimal, Bohr, Vilhelm A, Harris, Curtis C

“…BLM, WRN, and p53 are involved in the homologous DNA recombination pathway. The DNA structure-specific helicases, BLM and WRN, unwind Holliday junctions (HJ),…”
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Studies on the Mechanism of Inactivation of the HIV-1 Nucleocapsid Protein NCp7 with 2-Mercaptobenzamide Thioesters by Miller Jenkins, Lisa M, Byrd, J. Calvin, Hara, Toshiaki, Srivastava, Pratibha, Mazur, Sharlyn J, Stahl, Stephen J, Inman, John K, Appella, Ettore, Omichinski, James G, Legault, Pascale

“…The HIV-1 nucleocapsid protein (NCp7) is a small basic protein with two CysCysHisCys zinc-binding domains that specifically recognizes the Ψ-site of the viral…”
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Double Helical DNA: Conformations, Physical Properties, and Interactions with Ligands by Record, M T, Mazur, S J, Melancon, P, Roe, J H, Shaner, S L, Unger, L

“…Substantial progress has been made recently in understanding the unique physical features of double helical DNA and their implications for its interactions…”
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Inhibition of RNA Polymerase II Transcription in Human Cell Extracts by Cisplatin DNA Damage by Cullinane, Carleen, Mazur, Sharlyn J, Essigmann, John M, Phillips, Don R, Bohr, Vilhelm A

“…The anticancer drug cisplatin induces a spectrum of lesions in DNA. The effect of such DNA damage on transcription by RNA polymerase II (RNA pol II) in human…”
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Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action by Basrur, V, Song, Y, Mazur, S J, Higashimoto, Y, Turpin, J A, Rice, W G, Inman, J K, Appella, E

“…The synthesis and antiviral properties of pyridinioalkanoyl thioester (PATE) compounds that target nucleocapsid p7 protein (NCp7) of the human immunodeficiency…”
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Efficient in vitro repair of 7-hydro-8-oxodeoxyguanosine by human cell extracts: Involvement of multiple pathways by Jaiswal, Meeta, Lipinski, Leonora J., Bohr, Vilhelm A., Mazur, Sharlyn J.

“…To investigate the repair of oxidative damage in DNA, we have established an in vitro assay utilizing human lymphoblastoid whole cell extracts and plasmid DNA…”
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Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain by Mazur, S J, Sakaguchi, K, Appella, E, Wang, X W, Harris, C C, Bohr, V A

“…The C-terminal domain of the tumor suppressor protein p53 is the site of non-specific DNA binding. Purified p53 produced from baculovirus-infected insect cells…”
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Kinetics of nonspecific binding reactions of proteins with DNA flexible coils: site-based and molecule-based association reactions by Mazur, S J, Record, Jr, M T

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Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites by Rossi, Matteo, Demidov, Oleg N, Anderson, Carl W, Appella, Ettore, Mazur, Sharlyn J

“…PPM1D (Wip1), a type PP2C phosphatase, is expressed at low levels in most normal tissues but is overexpressed in several types of cancers. In cells containing…”
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Fmoc-based chemical synthesis and selective binding to supercoiled DNA of the p53 C-terminal segment and its phosphorylated and acetylated derivatives by Teruya, Kenta, Murphy, Angela C., Burlin, Tom, Appella, Ettore, Mazur, Sharlyn J.

“…The C‐terminal domain of p53 comprises a linker, the tetramerization domain and the regulatory domain, and contains at least seven sites of potential…”
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p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression by Xu, Yang, Lin, Tongxiang, Chao, Connie, Saito, Shin'ichi, Mazur, Sharlyn J, Murphy, Maureen E, Appella, Ettore

“…The tumour suppressor p53 becomes activated in response to upstream stress signals, such as DNA damage, and causes cell-cycle arrest or apoptosis. Here we…”
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Association kinetics of site-specific protein-DNA interactions: roles of nonspecific DNA sites and of the molecular location of the specific site by Mazur, S J, Record, Jr, M T

“…We have applied the formalism developed previously for the kinetics of domain-localized reactions [S. Mazur and M. T. Record, Jr. (1986) Biopolymers 25,…”
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Dynamics of the Escherichia coli nucleotide excision repair system by Grossman, L, Caron, P R, Mazur, S J, Oh, E Y

“…Ultraviolet light induced pyrimidine dimers in DNA are recognized and repaired by a number of unique cellular surveillance systems. At the highest level of…”
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Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression by Horikawa, Izumi, Cable, P LouAnn, Mazur, Sharlyn J, Appella, Ettore, Afshari, Cynthia A, Barrett, J Carl

“…Regulation of the hTERT gene encoding the telomerase catalytic subunit plays an important role in human cell senescence, immortalization, and carcinogenesis…”
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Stereospecific Differences in Repair by Human Cell Extracts of Synthesized Oligonucleotides Containing trans-Opened 7,8,9,10-Tetrahydrobenzo[a]pyrene 7,8-Diol 9,10-Epoxide N super(2)-dG Adduct Stereoisomers Located within the Human K-ras Codon 12 Sequence by Custer, L, Zajc, B, Sayer, J M, Cullinane, C, Phillips, DR, Cheh, A M, Jerina, D M, Bohr, V A, Mazur, S J

“…The potent environmental carcinogen benzo[a]pyrene (BaP), following enzymatic activation to enantiomeric pairs of bay-region 7,8-diol 9,10-epoxides (the…”
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