Search Results - "Mazur, Pawel Karol"
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METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis
Published in Cell (24-01-2019)“…Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A…”
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Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment
Published in Gut (01-04-2023)“…Many cancers engage embryonic genes for rapid growth and evading the immune system. SOX9 has been upregulated in many tumours, yet the role of SOX9 in…”
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Comprehensive molecular phenotyping of ARID1A -deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities
Published in Gut (01-09-2023)“…Gastric cancer (GC) is a leading cause of cancer mortality, with being the second most frequently mutated driver gene in GC. We sought to decipher -specific GC…”
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FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
Published in Molecular cell (02-05-2024)“…eEF2 post-translational modifications (PTMs) can profoundly affect mRNA translation dynamics. However, the physiologic function of eEF2K525 trimethylation…”
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Abstract P28: Comprehensive Molecular Phenotyping of ARID1A -deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities
Published in Cancer research (Chicago, Ill.) (15-04-2024)“…Objective Gastric cancer (GC) is a leading cause of cancer mortality, with ARID1A being the second most frequently mutated driver gene in GC. We sought to…”
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