Search Results - "Mazumder, Shibnath"

TLRs in Mycobacterial Pathogenesis: Black and White or Shades of Gray by Mehta, Priyanka, Ray, Atish, Mazumder, Shibnath

“…Toll-like receptors (TLRs) play critical role in the innate recognition of pathogens besides orchestrating innate and adaptive immune responses. These…”
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Role of UPRmt and mitochondrial dynamics in host immunity: it takes two to tango by Kumar, Manmohan, Sharma, Shagun, Mazumder, Shibnath

“…The immune system of a host contains a group of heterogeneous cells with the prime aim of restraining pathogenic infection and maintaining homeostasis. Recent…”
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Aeromonas hydrophila inhibits autophagy triggering cytosolic translocation of mtDNA which activates the pro-apoptotic caspase-1/IL-1β-nitric oxide axis in headkidney macrophages by Kumar, Manmohan, Shelly, Asha, Dahiya, Priyanka, Ray, Atish, Mazumder, Shibnath

“…The molecular mechanisms underlying Aeromonas hydrophila-pathogenesis are not well understood. Using head kidney macrophages (HKM) of Clarias gariepinus, we…”
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mtROS Induced via TLR-2-SOCE Signaling Plays Proapoptotic and Bactericidal Role in Mycobacterium fortuitum -Infected Head Kidney Macrophages of Clarias gariepinus by Dahiya, Priyanka, Hussain, Md Arafat, Mazumder, Shibnath

“…The mechanisms underlying -induced mycobacteriosis remain unexplored. Using head kidney macrophages (HKM) from catfish ( ), we report that Ca surge across…”
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TLR22-Induced Pro-Apoptotic mtROS Abets UPRmt-Mediated Mitochondrial Fission in Aeromonas hydrophila-Infected Headkidney Macrophages of Clarias gariepinus by Kumar, Manmohan, Sharma, Shagun, Haque, Munira, Kumar, Jai, Hathi, Umesh Prasad Sah, Mazumder, Shibnath

“…Toll-like receptors (TLRs) are epitomized as the first line of defense against pathogens. Amongst TLRs, TLR22 is expressed in non-mammalian aquatic…”
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β-Catenin Elicits Drp1-Mediated Mitochondrial Fission Activating the Pro-Apoptotic Caspase-1/IL-1β Signalosome in Aeromonas hydrophila -Infected Zebrafish Macrophages by Sharma, Shagun, Kumar, Manmohan, Kumar, Jai, Mazumder, Shibnath

“…Canonical Wnt signaling plays a major role in regulating microbial pathogenesis. However, to date, its involvement in infection is not well known. Using…”
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miR-155-Induced Activation of Pro-Inflammatory Stat1/TBX21 Pathway and M1-Signature Genes Incite Macrophage Apoptosis and Clearance of Mycobacterium fortuitum in Zebrafish by Mehta, Priyanka, Datta, Debika, Dahiya, Priyanka, Mazumder, Shibnath

“…The role of microRNAs (miRNAs) in Mycobacterium fortuitum pathogenesis is not well illustrated. Using zebrafish kidney macrophages (ZFKM) we observed that M…”
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Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response by Kumar, Manmohan, Sharma, Shagun, Kumar, Jai, Barik, Sailen, Mazumder, Shibnath

“…Macrophages restrain microbial infection and reinstate tissue homeostasis. The mitochondria govern macrophage metabolism and serve as pivot in innate immunity,…”
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Role of calmodulin-calmodulin kinase II, cAMP/protein kinase A and ERK 1/2 on Aeromonas hydrophila-induced apoptosis of head kidney macrophages by Banerjee, Chaitali, Khatri, Preeti, Raman, Rajagopal, Bhatia, Himanshi, Datta, Malabika, Mazumder, Shibnath

“…The role of calcium (Ca2+) and its dependent protease calpain in Aeromonas hydrophila-induced head kidney macrophage (HKM) apoptosis has been reported. Here,…”
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Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection by Majumdar, Tanmay, Sharma, Shagun, Kumar, Manmohan, Hussain, Md. Arafat, Chauhan, Namita, Kalia, Inderjeet, Sahu, Amit Kumar, Rana, Vipin Singh, Bharti, Ruchi, Haldar, Arun Kumar, Singh, Agam P., Mazumder, Shibnath

“…Recent studies have documented the diverse role of host immunity in infection by the protozoan parasite, Toxoplasma gondii . However, the contribution of the…”
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Aeromonas hydrophila induced head kidney macrophage apoptosis in Clarias batrachus involves the activation of calpain and is caspase-3 mediated by Banerjee, Chaitali, Goswami, Ramansu, Verma, Gaurav, Datta, Malabika, Mazumder, Shibnath

“…► Altered Ca2+ homeostasis initiates A. hydrophila-induced HKM apoptosis. ► Calpain-2 activation is a major event in the process. ► Calpain-2 activation leads…”
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Calcium and Superoxide-Mediated Pathways Converge to Induce Nitric Oxide-Dependent Apoptosis in Mycobacterium fortuitum-Infected Fish Macrophages by Datta, Debika, Khatri, Preeti, Banerjee, Chaitali, Singh, Ambika, Meena, Ramavatar, Saha, Dhira Rani, Raman, Rajagopal, Rajamani, Paulraj, Mitra, Abhijit, Mazumder, Shibnath

“…Mycobacterium fortuitum causes 'mycobacteriosis' in wide range of hosts although the mechanisms remain largely unknown. Here we demonstrate the role of calcium…”
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Arsenic-induced alteration in intracellular calcium homeostasis induces head kidney macrophage apoptosis involving the activation of calpain-2 and ERK in Clarias batrachus by Banerjee, Chaitali, Goswami, Ramansu, Datta, Soma, Rajagopal, R., Mazumder, Shibnath

“…We had earlier shown that exposure to arsenic (0.50 μM) caused caspase-3 mediated head kidney macrophage (HKM) apoptosis involving the p38-JNK pathway in…”
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Characterization of a galactose binding serum lectin from the Indian catfish, Clarias batrachus: Possible involvement of fish lectins in differential recognition of pathogens by Dutta, Suvendu, Sinha, Biswajit, Bhattacharya, Bidisha, Chatterjee, Bishnupada, Mazumder, Shibnath

“…A lectin with molecular mass around 200 kDa was isolated from the serum of the Indian catfish Clarias batrachus. The bioactivity of this serum lectin was Ca 2+…”
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Virulence plasmid of Aeromonas hydrophila induces macrophage apoptosis and helps in developing systemic infection in mice by Majumdar, Tanmay, Chattopadhyay, Pritam, Saha, Dhira Rani, Sau, Subrato, Mazumder, Shibnath

“…Pathogenic Aeromonas hydrophila Strain AO1 bears a 21 kb plasmid encoding several virulence determinants. Infection studies revealed that this isolate induced…”
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Arsenic induced alteration in Mrp-1 like activity leads to zebrafish hepatocyte apoptosis: The cellular GSH connection by Ray, Atish, Shelly, Asha, Roy, Sonali, Mazumder, Shibnath

“…[Display omitted] •Arsenic exposure results in early induction of GSH and MRP-1ATPase activity in ZFH (Zebrafish hepatocytes).•Cellular GSH content of ZFH…”
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Th1–Th2 and M1-M2 interplay sculpt Aeromonas hydrophila pathogenesis in zebrafish (Danio rerio) by Kumar, Jai, Kumar, Manmohan, Sharma, Shagun, Srivastava, Nidhi, Singh, Rashmi, Hussain, Md Arafat, Mazumder, Shibnath

“…Aeromonas hydrophila is an important aquatic zoonotic pathogen that causes septicemia, necrotizing fasciitis and gastroenteritis in various aquatic and…”
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Identification of novel signature genes attesting arsenic-induced immune alterations in adult zebrafish (Danio rerio) by Ray, Atish, Bhaduri, Asani, Srivastava, Nidhi, Mazumder, Shibnath

“…[Display omitted] •Novel signature genes of arsenic induced immunotoxicity are identified.•Ahead of tissue specific response probable mechanism is predicted at…”
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Role of UPR mt and mitochondrial dynamics in host immunity: it takes two to tango by Kumar, Manmohan, Sharma, Shagun, Mazumder, Shibnath

“…The immune system of a host contains a group of heterogeneous cells with the prime aim of restraining pathogenic infection and maintaining homeostasis. Recent…”
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Chronic endosulfan exposure impairs immune response rendering Clarias gariepinus susceptible to microbial infection by Kumari, Usha, Singh, Rashmi, Mazumder, Shibnath

“…•Endosulfan impairs phagocytic and bactericidal potential of headkidney macrophages.•Endosulfan abrogates T-cell proliferation and antibody production in…”
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