Search Results - "Mazucanti, Caio Henrique"

Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration by Mazucanti, Caio Henrique, Cabral-Costa, João Victor, Vasconcelos, Andrea Rodrigues, Andreotti, Diana Zukas, Scavone, Cristoforo, Kawamoto, Elisa Mitiko

“…Recent data from epidemiologic studies have shown that the majority of the public health costs are related to age-related disorders, and most of these diseases…”
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Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal culture by Nakao, Vinicius Wanatable, Mazucanti, Caio Henrique Yokowama, de Sá Lima, Larissa, de Mello, Paloma Segura, de Souza Port’s, Natacha Medeiros, Kinoshita, Paula Fernanda, Leite, Jacqueline Alves, Kawamoto, Elisa Mitiko, Scavone, Cristoforo

“…The α-Klotho is an anti-aging protein that, when overexpressed, extends the life span in humans and mice. It has an anti-inflammatory and protective action on…”
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SARS-CoV-2 disease severity and diabetes: why the connection and what is to be done? by Mazucanti, Caio Henrique, Egan, Josephine Mary

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus responsible for the current coronavirus disease 2019 (COVID-19) pandemic, has…”
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The relevance of α-KLOTHO to the central nervous system: Some key questions by Lopes-Cararo, Marina Minto, Mazucanti, Caio Henrique Yokoyama, Scavone, Cristoforo, Kawamoto, Elisa Mitiko, Berwick, Daniel Charles

“…Highlights • α-Klotho is essential for maintaining cognitive function and brain health. • “Brain α-Klotho” is proposed as a distinct and vital pool of…”
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Klotho increases antioxidant defenses in astrocytes and ubiquitin–proteasome activity in neurons by Orellana, Ana Maria, Mazucanti, Caio Henrique, dos Anjos, Leticia Pavan, de Sá Lima, Larissa, Kawamoto, Elisa Mitiko, Scavone, Cristoforo

“…Klotho is an antiaging protein, and its levels decline with age and chronic stress. The exogenous administration of Klotho can enhance cognitive performance in…”
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Insulin and Autophagy in Neurodegeneration by de Mello, Natália Prudente, Orellana, Ana Maria, Mazucanti, Caio Henrique, de Morais Lima, Geovanni, Scavone, Cristoforo, Kawamoto, Elisa Mitiko

“…Crosstalk in the pathophysiological processes underpinning metabolic diseases and neurodegenerative disorders have been the subject of extensive investigation,…”
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AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences by Mazucanti, Caio Henrique, Kennedy, Vernon, Premathilake, Hasitha U., Doyle, Maire E., Tian, Jane, Liu, Qing-Rong, O’Connell, Jennifer, Camandola, Simonetta, Egan, Josephine M.

“…The choroid plexus (CP) is a source of trophic factors for the developing and mature brain. Insulin is produced in epithelial cells of the CP (EChPs), and its…”
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Release of insulin produced by the choroid plexis is regulated by serotonergic signaling by Mazucanti, Caio Henrique, Liu, Qing-Rong, Lang, Doyle, Huang, Nicholas, O'Connell, Jennifer F, Camandola, Simonetta, Egan, Josephine M

“…The choroid plexus (ChP) is a highly vascularized tissue found in the brain ventricles, with an apical epithelial cell layer surrounding fenestrated…”
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Early and late neurodegeneration and memory disruption after intracerebroventricular streptozotocin by Santos, Taisa de Oliveira, Mazucanti, Caio Henrique Yokoyama, Xavier, Gilberto Fernando, Torrão, Andréa da Silva

“…Abstract Glucose metabolism and insulin signaling disruptions in the brain have been proposed as a likely etiology of Alzheimer's disease. The aim of the…”
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Corrigendum to “Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice” [Mol Metab 82 (2024 April) 101906] by Aseer, Kanikkai Raja, Mazucanti, Caio Henrique, O’Connell, Jennifer F., González-Mariscal, Isabel, Verma, Anjali, Yao, Qin, Dunn, Christopher, Liu, Qing-Rong, Egan, Josephine M., Doyle, Máire E.

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Hepatocyte cannabinoid 1 receptor nullification alleviates toxin-induced liver damage via NF-κB signaling by Kim, Yoo, Gautam, Sudeep, Aseer, Kanikkai Raja, Kim, Jaekwan, Chandrasekaran, Prabha, Mazucanti, Caio Henrique, Ghosh, Paritosh, O’Connell, Jennifer F., Doyle, Máire E., Appleton, Ashley, Lehrmann, Elin, Liu, Qing-Rong, Egan, Josephine M.

“…Cannabinoid 1 receptor (CB1R) expression is upregulated in the liver with viral hepatitis, cirrhosis, and both alcoholic and non-alcoholic fatty liver disease…”
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Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice by Aseer, Kanikkai Raja, Mazucanti, Caio Henrique, O’Connell, Jennifer F., González-Mariscal, Isabel, Verma, Anjali, Yao, Qin, Dunn, Christopher, Liu, Qing-Rong, Egan, Josephine M., Doyle, Máire E.

“…Type 1 diabetes (T1D) occurs because of islet infiltration by autoreactive immune cells leading to destruction of beta cells and it is becoming evident that…”
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The Role of Steroid Hormones in the Modulation of Neuroinflammation by Dietary Interventions by Vasconcelos, Andrea Rodrigues, Cabral-Costa, João Victor, Mazucanti, Caio Henrique, Scavone, Cristoforo, Kawamoto, Elisa Mitiko

“…Steroid hormones, such as sex hormones and glucocorticoids, have been demonstrated to play a role in different cellular processes in the central nervous…”
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Dietary curcumin restores insulin homeostasis in diet-induced obese aged mice by Lee, Su-Jeong, Chandrasekran, Prabha, Mazucanti, Caio Henrique, O'Connell, Jennifer F, Egan, Josephine M, Kim, Yoo

“…Although aging is a physiological process to which all organisms are subject, the presence of obesity and type 2 diabetes accelerates biological aging. Recent…”
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Dietary Curcumin Systemically Maintains Insulin Homeostasis in Diet-Induced Aged Obese Mice via Liver-Pancreas-Brain Axis by Kim, Yoo, Mazucanti, Caio Henrique, O’Connell, Jennifer F., Egan, Josephine M.

“…Aging is a condition in which we gradually lose the ability to maintain homeostasis due to dysfunction. There continues to be a knowledge gap in implicating…”
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NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance by Crunfli, Fernanda, Mazucanti, Caio Henrique, de Moraes, Ruan Carlos Macêdo, Costa, Andressa Pereira, Rodrigues, Alice Cristina, Scavone, Cristoforo, Torrão, Andréa da Silva

“…Sporadic Alzheimer's disease (sAD) is associated with energy metabolism deficiency and impairment of insulin receptor (IR) signaling in the brain. In this…”
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